The Biology and Clinical Features of Cutaneous Polyomaviruses

Nguyen, Khang; Chamseddin, Bahir; Cockerell, Clay J.; Wang, Richard C.

doi:10.1016/j.jid.2018.09.013

Cited by 19 publications

(9 citation statements)

References 99 publications

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“…13,14 Other therapies including leflunomide and routine manual extraction of spicules also have shown effectiveness in the treatment of trichodysplasia spinulosa. 15 In our patient, treatment included decreasing immunosuppression, as she was getting recurrent sinus and upper respiratory infections. Mycophenolate mofetil was discontinued, and the patient was continued solely on tacrolimus therapy.…”

Section: The Diagnosismentioning

confidence: 85%

Widespread Hyperkeratotic Papules in a Transplant Recipient

Firsowicz¹,

Cervantes²,

Diaz³

2021

Cutis

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A 4-year-old girl with a history of cardiac transplantation 1 year prior for dilated cardiomyopathy presented to the dermatology consultation service with widespread hyperkeratotic papules of 2 months' duration. The eruption initially had appeared on the face with subsequent involvement of the trunk and extremities. Her immunosuppressive medications included oral tacrolimus and mycophenolate mofetil. No over-the-counter or prescription treatments had been used for the eruption; the patient's mother had been manually extracting the spicules from the nose, cheeks, and forehead with tweezers. The lesions were asymptomatic with only mild follicular erythema. Physical examination revealed multiple folliculocentric keratinous spicules on the nose, cheeks, forehead (top), trunk (bottom), arms, and legs. WHAT'S YOUR DIAGNOSIS? a. filiform warts b. keratosis pilaris c. lichen spinulosus d. milia e. trichodysplasia spinulosa

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Section: The Diagnosismentioning

confidence: 85%

Widespread Hyperkeratotic Papules in a Transplant Recipient

Firsowicz¹,

Cervantes²,

Diaz³

2021

Cutis

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“…The transmission routes have not been clarified for any of the HPyVs, but infection of the skin may occur for the four above-mentioned viruses, resulting in persistent/latent infection. These infections are thought to be asymptomatic in the vast majority of patients, but they can result in severe consequences, mainly in immunocompromised patients [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Four Polyomaviruses Linked to Dermatological Diseases: New Findings and a Comprehensive Analysis

Jeles

Katona

Csoma

2022

Viruses

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Our aim was to study the seroprevalence of human polyomaviruses (HPyV) linked to skin diseases. A total of 552 serum samples were analysed by the enzyme-linked immunosorbent assay to detect IgG antibodies against Merkel cell polyomavirus (MCPyV), HPyV6, HPyV7 and Trichodysplasia spinulosa-associated polyomavirus (TSPyV) using recombinant major capsid proteins of these viruses. The individuals (age 0.8–85 years, median 33) were sorted into seven age groups: <6, 6–10, 10–14, 14–21, 21–40, 40–60 and >60 years. The adulthood seroprevalence was 69.3%, 87.7%, 83.8% and 85% for MCPyV, HPyV6, HPyV7 and TSPyV, respectively. For all four polyomaviruses, there was increasing seropositivity with age until reaching the adulthood level. There was a significant increase in seroreactivity for those age groups in which the rate of already-infected individuals also showed significant differences. The adulthood seropositvity was relatively stable with ageing, except for TSPyV, for which elevated seropositivity was observed for the elderly (>60 years) age group. Since seroepidemiological data have been published with wide ranges for all the viruses studied, we performed a comprehensive analysis comparing the published age-specific seropositivities to our data. Although the cohorts, methods and even the antigens were variable among the studies, there were similar results for all studied polyomaviruses. For MCPyV, geographically distinct genotypes might exist, which might also result in the differences in the seroprevalence data. Additional studies with comparable study groups and methods are required to clarify whether there are geographical differences.

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“…In recent years, several viruses have been proposed as playing a role in the development of skin cancers [17,18], although among HPyVs, a viral-causal role has been established only for MCC [10]. It is therefore reasonable to determine whether a virus or viruses, such as cutaneous HPyVs, could contribute to the risk of the development of skin cancers.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens

Prezioso

Brazzini

Passerini

et al. 2022

Viruses

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To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for cutaneous HPyVs in the development of skin malignant lesions, we investigated the prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in actinic keratosis (AK), a premalignant skin lesion that has the potential to progress towards a squamous cell carcinoma (SCC). One skin lesion and one non-lesion skin from nine affected individuals were analyzed by qualitative PCR. MCPyV was detected in 9 out of 9 lesion biopsies and 6 out of 8 non-lesion biopsies. HPyV6 was detected only in healthy skin, while HPyV7 and TSPyV were not detected in any skin sample. These findings argue against a possible role of cutaneous HPyVs in AK. However, considering the small sample size analyzed, a definitive conclusion cannot be drawn. Longitudinal studies on large cohorts are warranted.

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The Biology and Clinical Features of Cutaneous Polyomaviruses

Cited by 19 publications

References 99 publications

Widespread Hyperkeratotic Papules in a Transplant Recipient

Widespread Hyperkeratotic Papules in a Transplant Recipient

Seroprevalence of Four Polyomaviruses Linked to Dermatological Diseases: New Findings and a Comprehensive Analysis

Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens

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