The biology and chemistry of hyperlipidemia

Jain, Kishor S.; Kathiravan, M. K.; Somani, Rahul; Shishoo, C. J.

doi:10.1016/j.bmc.2007.04.031

Cited by 206 publications

(113 citation statements)

References 121 publications

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“…Elevation of LDL-C and TC and reduction of high density lipoprotein level is associated with progression of atherosclerotic lesions (Harrison et al, 2003; Minhajuddin et al, 2005; Jain et al, 2007). In various studies, it has been reported that HCF rat significantly increased ( p < 0.05) the levels of TC, HDL, LDL, VLDL, TGs, and also significantly decreased the level of HDL in the serum (Devi and Sharma, 2004).…”

Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

et al. 2016

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The study aimed to identify the phenolic compounds present in Centella asiatica (L.) (C. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. The anti-hyperlipidemic effects of C. asiatica extract (CAE) were evaluated in high cholesterol-fed (HCF) rats for 4 weeks, where different concentrations of extracts (0.25, 0.5, and 1 g/kg/day) were orally administrated daily. Lipid and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD), together with the indices of hepatic functions were also examined. C. asiatica revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay, with the IC50 values (9.62 ± 0.88 μg/mL). Furthermore, C. asiatica extracts and fenofibrate remarkably lowered the level of TC, TG, LDL-C, and showed elevated levels of HDL-C, SOD. The histopathological observations further demonstrated clear differentiation and structural changes in liver of HCF and CAE treated group. Furthermore, gulonic acid, ferulic acid, kaempferol, chlorogenic acid, and asiatic acid were identified to be the major components which might be responsible for the antioxidant activity of the C. asiatica extract as evidenced from an ultra-high performance liquid chromatography–mass spectrometer. Taken together, these results signifies the excellent antioxidant and anti-hyperlipidemic properties of C. asiatica leaf extracts, which might be useful for the treatment of oxidative-stress related diseases such as hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

et al. 2016

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“…Anticancer potential of gymnemagenol on HeLa cancer cell lines in in vitro conditions, was determined [78]. The cytotoxic activity of the saponins was tested by MTT cell proliferation assay.…”

Section: Pharmacological Activities Of Extracts and Pure Compoundsmentioning

confidence: 99%

Phytochemical and Pharmacological Properties ofGymnema sylvestre: An Important Medicinal Plant

Tiwari

Mishra

Sangwan

2014

BioMed Research International

190

133

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Gymnema sylvestre (Asclepiadaceae), popularly known as “gurmar” for its distinct property as sugar destroyer, is a reputed herb in the Ayurvedic system of medicine. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. The herb exhibits a broad range of therapeutic effects as an effective natural remedy for diabetes, besides being used for arthritis, diuretic, anemia, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation, microbial infections, indigestion, and anti-inflammatory. G. sylvestre has good prospects in the treatment of diabetes as it shows positive effects on blood sugar homeostasis, controls sugar cravings, and promotes regeneration of pancreas. The herbal extract is used in dietary supplements since it reduces body weight, blood cholesterol, and triglyceride levels and holds great prospects in dietary as well as pharmacological applications. This review explores the transition of a traditional therapeutic to a modern contemporary medication with an overview of phytochemistry and pharmacological activities of the herb and its phytoconstituents.

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“…Hyperlipidemia, resulting from the abnormalities of lipid homeostasis, is a common risk factor for the development of CVD [2]. It is well known that the increase of total cholesterol and particularly of LDL-cholesterol (LDL-C) is positively associated with the risk of CVD, while high values of HDL-cholesterol (HDL-C) are inversely correlated with the risk of CVD [3].…”

Section: Introductionmentioning

confidence: 99%

MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review

Rondanelli

Giacosa²,

Morazzoni

et al. 2016

BioMed Research International

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Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjects. Methods. A systematic review has been done involving all the English written studies published from the 1st of January 1958 to the 31st of March 2016. Results. The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels. The artichoke leaf extract and virgin olive oil appear to be particularly interesting, while bergamot extract needs further research and the effect of red yeast rice seems to be limited to patients with previous myocardial infarction. Conclusions. Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.

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The biology and chemistry of hyperlipidemia

Cited by 206 publications

References 121 publications

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

Phytochemical and Pharmacological Properties ofGymnema sylvestre: An Important Medicinal Plant

MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review

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