The biologically relevant parameter in nerve impulse trains

McKean, T. A.; Poppele, R. E.; Rosenthal, N. Paul; Terzuolo, C

doi:10.1007/bf00273961

Cited by 48 publications

(12 citation statements)

References 2 publications

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“…They certainly cannot do so when operating in the linear part of their response curve because obviously in the last situation the system is 'bidirectionally' rate sensitive (Franz, 1969), and as a result, the average discharge rate which in all likelihood is the information carrying parameter rather than the instantaneous frequency (Douglas, Ritchie & Schaumann, 1956;Gupta, Henry, Sinclair & Von Baumgarten, 1966;McKean, Poppele, Rosenthal & Terzuolo, 1970;Eysel & GrUsser, 1970) is identical for static and dynamic inputs in agreement with Angell James (1971 a). From this point of view, 'unidirectional' rate sensitivity is not a basic property of the receptors themselves, a notion held by Clynes (1961), it rather is the consequence of the receptor's near-threshold operation.…”

Section: Discussionsupporting

confidence: 63%

The aortic arch baroreceptor response to static and dynamic stretches in an isolated aorta‐depressor nerve preparation of cats in vitro.

Arndt¹,

Dörrenhaus²,

Wiecken³

1975

The Journal of Physiology

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Section: Discussionsupporting

confidence: 63%

The aortic arch baroreceptor response to static and dynamic stretches in an isolated aorta‐depressor nerve preparation of cats in vitro.

Arndt¹,

Dörrenhaus²,

Wiecken³

1975

The Journal of Physiology

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“…More formal discussion of these matters may be found elsewhere (Matthews & Stein, 1969;Poppele &. Bowman, 1970;McKean, Poppele, Rosenthal & Terzuolo, 1970).…”

Section: Methodsmentioning

confidence: 99%

The effects of fusimotor stimulation during small amplitude stretching on the frequency‐response of the primary ending of the mammalian muscle spindle.

Goodwin¹,

Hulliger²,

Matthews³

1975

The Journal of Physiology

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SUMMARY1. Single fusimotor fibres to the de-efferented soleus of the anaesthetized cat were stimulated repetitively while recording the response of single primary afferents to small amplitude sinusoidal stretching at frequencies of 0'5-500 Hz. The response of the ending was determined by averaging its firing for many cycles to construct a 'cycle histogram'. When small enough, the stretching modulated the firing sinusoidally; as the frequency increased the requisite amplitude fell to a fraction of a micron. The amplitude of the modulation (in impulses/sec) divided by the amplitude of stretching (in mm) gave the sensitivity of the ending for the particular frequency in question.2

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“…Workers involved with information theory (McKean, Poppele, Rosenthal & Terzuolo, 1970) have already drawn attention to the fact that the Bode plots of a system responding to the interspike interval in nerve spike trains is quite distinct and different from those of a system which responds to the running average of the spike count.…”

Section: Introductionmentioning

confidence: 99%

The physiologically relevant information regarding systemic blood pressure encoded in the carotid sinus baroreceptor discharge pattern.

Arndt¹,

Morgenstern²,

Samodelov³

1977

The Journal of Physiology

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SUMMARY1. The objective was to find out what kind of information regarding systemic blood pressure is transduced by baroreceptors in vivo and how this information is coded in the receptor discharge.2. Carotid sinus pressure, e.c.g., and receptor action potentials were recorded for fifty-two single fibre carotid sinus receptors found in twenty decerebrated unanaesthetized cats. 3. The inflation and gradual deflation of an intraaortic catheter tip balloon manipulated the blood pressure in the carotid sinus in a way as to define the full in vivo stimulus-response curve for each receptor.4. Correlation coefficients were computed between stimulus and response variables for several points on the response curve of each receptor and for every possible combination of stimulus and response variables defined.5. Stimulus variables were (a) systolic, (b) diastolic, (c) mean, (d) pulse pressures and (e) peak positive dP/dt. Response variables were (a) average discharge rate, (b) peak instantaneous frequency, and (c) average burst frequency.6. For every fibre in the sample only the correlations between systolic, diastolic and mean pressures vs. average discharge rate were consistently high and positive. All other correlations were numerically low and/or negative.7. It was concluded that in vivo baroreceptors signal mainly pressure level (systolic, diastolic or mean) as opposed to pulse pressure or dP/dt, and that the average discharge rate is their best index of information content.

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The biologically relevant parameter in nerve impulse trains

Cited by 48 publications

References 2 publications

The aortic arch baroreceptor response to static and dynamic stretches in an isolated aorta‐depressor nerve preparation of cats in vitro.

The aortic arch baroreceptor response to static and dynamic stretches in an isolated aorta‐depressor nerve preparation of cats in vitro.

The effects of fusimotor stimulation during small amplitude stretching on the frequency‐response of the primary ending of the mammalian muscle spindle.

The physiologically relevant information regarding systemic blood pressure encoded in the carotid sinus baroreceptor discharge pattern.

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