The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease

Stephens, Jeffrey W.; Khanolkar, Manish; Bain, Stephen C.

doi:10.1016/j.atherosclerosis.2008.06.006

Cited by 226 publications

(166 citation statements)

References 103 publications

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“…Elevations in oxidative stress and of 'pro-inflammatory' cytokines such as TGF-β and TNF-α have been implicated in the mechanisms of diabetic cardiac, vascular and renal complications [30,[33][34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Gong

Choong

et al. 2010

Diabetologia

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Aims/hypothesis Treatment with the Cu(II)-selective chelator triethylenetetramine (TETA) improves cardiovascular disease in human patients, and cardiac and vascular/renal disease in rats used as a model of diabetes. Here we tested two hypotheses: first, that TETA elicits greater improvement in organ function than less Cu-selective transition-metal-targeted treatments; second, that the therapeutic actions of TETA are consistent with mediation through suppression of oxidative stress.Methods Rats were made diabetic with streptozotocin (55 mg/kg, i. v.) and treated from 8 weeks after disease induction for the following 8 weeks with effective dosages of oral TETA, or one of three less Cu-selective transitionmetal-targeted treatments: D-penicillamine, deferiprone or Zn acetate. Treatment effects were measured in ex vivo cardiac and aortic tissues, plasma and urine. Results Diabetes damaged both cardiac and renal/vascular function by impairing the ability of cardiac output to respond physiologically to rising afterload, and by significantly elevatElectronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 99%

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Gong

Choong

et al. 2010

Diabetologia

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“…Inadequate intakes of vitamins C and E observed in our study and by others may reflect a diet with low amount or poor variety of fruits and vegetables (7,51) . This is of importance because antioxidants commonly found in fruits and vegetables (vitamins A, C, and E, carotenoids and polyphenols) have been associated with lower chronic disease risk (52)(53)(54)(55) . The average total fibre intake observed in the present study (15·2 (SD 7·5) g/d for the older women and 13·5 (SD 7·1) g/d for the younger women) was far below current recommendations but consistent with previously reported data among older Mexican-American women (17 g/d) (56) and US women over 18 years of age (13-15 g/d) (50) .…”

Section: Micronutrient and Fibre Intakesmentioning

confidence: 99%

Comparison and evaluation of dietary quality between older and younger Mexican-American women

Pignotti

Vega‐López

Keller

et al. 2015

Public Health Nutr.

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Objective: To compare and evaluate the dietary quality of young and older sedentary Mexican-American women. Understanding key dietary concerns, while considering developmental transition periods and cultural relevance, can provide insight for developing appropriate nutrition interventions. Design: Cross-sectional dietary data were collected using unannounced 24 h diet recalls to assess nutrient intake adequacy (Estimated Average Requirement cut-point method) and dietary quality (Healthy Eating Index (HEI) 2010). Setting: Mujeres en Acción and Madres para la Salud, two community-based physical activity interventions. Subjects: Participants were 139 young (28 (SD 6) years) and 124 older (55 (SD 7) years) overweight/obese sedentary Mexican-American women (BMI = 25·0-35·0 kg/m 2 ) of low socio-economic status. Results: Older women consumed less Ca, Fe, folate, empty calories and energy from carbohydrate, but more fruit, vegetables, greens and beans, and fibre than younger women (all P < 0·05). Over 60 % of all participants had an intake below recommendations for fibre, Ca, vitamin E, vitamin C and folate. Both groups had low total HEI-2010 scores (62 for older and 63 for younger women; NS), with 57 % of older and 48 % of younger women classified as having a poor diet. Conclusions: Despite differences in nutrient requirements according to developmental transition periods (childbearing v. perimenopausal), overall, older and younger Mexican-American women generally had low-quality diets and may benefit from dietary quality improvement.

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“…There is strong evidence that type 2 diabetes is associated with increased oxidative stress [1], which may contribute to the elevated risk of atherothrombosis. Oxidatively modified LDL are implicated in the pathogenesis of atherosclerosis and could be present in plasma from type 2 diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

et al. 2011

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Aims/hypothesis This study assessed oxidative stress in LDL from obese patients with the metabolic syndrome and compared it with that in LDL from type 2 diabetic patients or control volunteers. It also determined the effect on platelets of LDL from the three groups. Methods The profiles of lipids, fatty acids and fatty acid oxidation products were determined in LDL isolated from plasma of patients with the metabolic syndrome, patients with type 2 diabetes and volunteers (n=10 per group). The effects of LDL from the participant groups on the platelet arachidonic acid signalling cascade and aggregation were investigated. Results Compared with LDL from control volunteers, LDL from obese metabolic syndrome and type 2 diabetic patients had lower cholesteryl ester, higher triacylglycerol and lower ethanolamine plasmalogen levels. Proportions of linoleic acid were decreased in phosphatidylcholine and cholesteryl esters in LDL from both patient groups. Among the markers of lipid peroxidation, oxidation products of linoleic acid (hydroxy-octadecadienoic acids) and malondialdehyde were increased by 59% and twofold, respectively in LDL from metabolic syndrome and type 2 diabetic patients. LDL from metabolic syndrome and type 2 diabetic patients were equally potent in activating the platelet arachidonic acid signalling cascade through increased phosphorylation of p38 mitogen-activated protein kinase and cytosolic phospholipase A 2 , and through increased thromboxane B 2 formation. LDL from patients with the metabolic syndrome and type 2 diabetes potentiated platelet aggregation by threefold and 3.5-fold respectively, whereas control LDL had no activating effects on platelets. Conclusions/interpretation The metabolic syndrome in obese patients, without or with diabetes, is associated with increased oxidative stress in LDL, which triggers platelet activation.

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The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease

Cited by 226 publications

References 103 publications

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Comparison and evaluation of dietary quality between older and younger Mexican-American women

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

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