1968
DOI: 10.1016/0006-2952(68)90311-0
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The biological properties of peptides derived from fibrinogen

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1970
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Cited by 12 publications
(4 citation statements)
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“…Bradykinin-potentiating activity has been detected in snake venom other than that of B. jararaca Suzuki et al, 1967) in a mixture of peptides derived from trypsintreated plasma (Aarsen, 1968;Hamberg et al, 1968), in the peptidic fraction of a porcine liver extract (Tewksbury and Stahman, 1965), in some fibrinopeptides (Gladner et al, 1968), and in the carboxyl-terminal pentapeptide of bradykinin (Garbe, 1967). Of these, the amino acid sequence is known only for the fibrinopeptides and the bradykinin fragment.…”
Section: Discussionmentioning
confidence: 99%
“…Bradykinin-potentiating activity has been detected in snake venom other than that of B. jararaca Suzuki et al, 1967) in a mixture of peptides derived from trypsintreated plasma (Aarsen, 1968;Hamberg et al, 1968), in the peptidic fraction of a porcine liver extract (Tewksbury and Stahman, 1965), in some fibrinopeptides (Gladner et al, 1968), and in the carboxyl-terminal pentapeptide of bradykinin (Garbe, 1967). Of these, the amino acid sequence is known only for the fibrinopeptides and the bradykinin fragment.…”
Section: Discussionmentioning
confidence: 99%
“…On the one hand, initiation of clotting by thrombin involves the splitting off of two small bioactive peptides from fibrinogen monomer (31) and subsequent limited proteolysis of fibrinogen or fibrin by plasmin yields other biologically potent fragments (31). The phalmacologic properties of these fibrinogen/fibrin derivatives are as yet poorly characterized, particularly in man, but include potentiation of bradykinin-induced smooth muscle contraction (32), increased vascular permeability (33,34), and chemotaxis of granulocytes (35,36). Finally, insertion of a loose meshwork of long chain, insoluble fibrin polymer into the connective tissue matrix could lead to an expansion of the extravascular space with accumulation of water and plasma proteins.…”
Section: Discussionmentioning
confidence: 99%
“…' In the present work we evaluated the levels of some plasma precursors of kallikrein-kinin system in malignant hypertension, compared to "benign" hypertension and normal subjects, by studying plasma levels of kininogen, kallikrein, and prekallikrein. Also, a newly described kinin potentiating factor* was estimated in these subjects since it is known that several potentiating substances of both exogenous' 110 or endogenous origin 11 ' " may influence the activity of the kallikrein-kinin system.…”
mentioning
confidence: 99%