The Biological Promises of Endophytic Muscodor Species

Gupta, Mahiti; Meshram, Vineet

doi:10.1007/978-981-13-0393-7_4

Cited by 5 publications

(4 citation statements)

References 67 publications

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“…There exists a vast number of plant species on earth, exceeding 300,000, and each of these plants hosts a diverse range of microorganisms, broadly categorized as either epiphytes, endophytes, or pathogens [3,48]. Among them, endophytes comprise a diverse group of ubiquitous, polyphyletic microorganisms that reside within plant cells or in the intracellular space for at least a part of their life cycle, without showing any external manifestation of their presence [22,[49][50][51][52].…”

Section: What Is An Endophyte?mentioning

confidence: 99%

“…When selecting a host plant for endophyte isolation, preference should be given to plants with known medicinal properties. This approach enhances the likelihood of identifying endophytes that produce bioactive compounds relevant to human health [4,34,48,51]. Furthermore, establishing connections between fungal metabolites and plant genomics enhances our understanding of the biosynthetic pathways involved in the process, justifying the production of the metabolites based on scientific knowledge and evidence, rather than relying upon unproven hypotheses [1,5,18,22] The production of bioactive compounds from fungal endophytes on an industrial scale is a complex and arduous task, necessitating advanced and efficient approaches [23].…”

Section: Prospects and Challengesmentioning

confidence: 99%

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Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

et al. 2023

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The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a milestone in recognizing the immense potential of endophytic fungi as prolific producers of bioactive secondary metabolites of use in medicine, agriculture, and food industries. Following the discovery of paclitaxel, the research community has intensified efforts to harness endophytic fungi as putative producers of lead molecules with anticancer, anti-inflammatory, antimicrobial, antioxidant, cardio-protective, and immunomodulatory properties. Endophytic fungi have been a valuable source of bioactive compounds over the last three decades. Compounds such as taxol, podophyllotoxin, huperzine, camptothecin, and resveratrol have been effectively isolated and characterized after extraction from endophytic fungi. These findings have expanded the applications of endophytic fungi in medicine and related fields. In the present review, we systematically compile and analyze several important compounds derived from endophytic fungi, encompassing the period from 2011 to 2022. Our systematic approach focuses on elucidating the origins of endophytic fungi, exploring the structural diversity and biological activities exhibited by these compounds, and giving special emphasis to the pharmacological activities and mechanism of action of certain compounds. We highlight the tremendous potential of endophytic fungi as alternate sources of bioactive metabolites, with implications for combating major global diseases. This underscores the significant role that fungi can play in the discovery and development of novel therapeutic agents that address the challenges posed by prevalent diseases worldwide.

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Section: What Is An Endophyte?mentioning

confidence: 99%

Section: Prospects and Challengesmentioning

confidence: 99%

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

et al. 2023

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“…Induratia darjeelingensis showed inhibitory activity on xanthine oxidase, the main enzyme responsible for the production of uric acid (Kapoor and Saxena 2016). Therefore, some species of this genus showed promising antimicrobial, anti-obesity, and antioxidant activities and were reported as possible sources for the development of new pharmaceutical products (Kusari and Spiteller 2011;Demain 2014;Gupta and Meshram 2018;Hyde et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Metabolites from Induratia spp. modulating key enzymes in human hemostasis

et al. 2021

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Induratia spp. fungi have been poorly evaluated for their non-volatile secondary metabolites. In the present work, we evaluated the effects of non-volatile secondary metabolites released into the culture medium by Induratia spp. upon toxic alterations induced by Bothrops spp. venoms. B. atrox venom phospholipase was inhibited by Induratia spp. around 12 and 16%. The extracts of the two strains inhibited 12-25% of the hemolysis induced by B.moojeni venom. Thrombolysis was inhibited by 30-60% by the compounds present in both extracts. The coagulation induced by B. moojeni venom was prolonged by 26-41 s by the action of the extracts of I. coffeana. The fungal extracts did not exert any cytotoxic effect, nor did they induce any alteration in the other evaluated substrates show the potential use of non-volatile metabolites produced by the fungi evaluated as enzyme modulators, especially for proteases with a fundamental role in human hemostasis.

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“…I. darjeelingensis (as Muscodor) showed inhibitory activity on xanthine oxidase, the main enzyme responsible for the production of uric acid (Kapoor and Saxena 2016). Therefore, some species of this genus showed promising antimicrobial, anti-obesity, and antioxidant activities and were reported as possible sources for the development of new pharmaceutical products (Kusari and Spiteller 2011;Demain 2014;Gupta and Meshram 2018;Hyde et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Metabolites from Induratia spp. Modulating Key Enzymes in Human Hemostasis

Cardoso

Trento

César

et al. 2021

Preprint

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Fungi Induratia have been poorly evaluated for their non-volatile secondary metabolites. In the present work, we evaluated the effects of non-volatile secondary metabolites released into the culture medium by Induratia spp. upon toxic alterations induced by Bothrops spp. venoms. B. atrox venom phospholipase was inhibited by Induratia sp. and I. yucatanensis around 12 and 16%. The extracts of two strains inhibited 12 to 25% of the hemolysis induced by B.moojeni venom. Thrombolysis was inhibited by 30 to 60% by the compounds present in two extracts. The coagulation induced by B. moojeni venom was prolonged by 26 to 41 s by the action of the extracts of I. yucatanensis and I. coffeana. The fungal extracts did not exerted any cytotoxic effect, nor did they induce any alteration in the other evaluated substrates show the potential use of non-volatile metabolites produced by the fungi evaluated as enzyme modulators, especially for proteases with a fundamental role in human hemostasis.

show abstract

The Biological Promises of Endophytic Muscodor Species

Cited by 5 publications

References 67 publications

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

Fungal Endophytes: Microfactories of Novel Bioactive Compounds with Therapeutic Interventions; A Comprehensive Review on the Biotechnological Developments in the Field of Fungal Endophytic Biology over the Last Decade

Metabolites from Induratia spp. modulating key enzymes in human hemostasis

Metabolites from Induratia spp. Modulating Key Enzymes in Human Hemostasis

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