The biological half-life of radioactive phosphorus in the blood of patients with leukemia.I. Whole blood—with deviations of observations from predicted values and an estimate of total-phosphorus turnover rate

Tivey, Harold; Osgood, Edwin E.; Klink, Elizabeth; McKenzie, Maude; Hughes, Margret E.; Ort, Joan; Gustafson, Ivan; Fuller, M. F.; Klobucher, Victor; Stoddard, Hugh

doi:10.1002/1097-0142(1950)3:6<992::aid-cncr2820030607>3.0.co;2-w

Cited by 9 publications

(1 citation statement)

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“…Over the first 8 d after intravenous administration of 32 P to healthy subjects and leukemia patients, the 32 P concentration in whole blood, RBC, and plasma was moderately higher and in white blood cells was substantially higher in the patients than in the healthy subjects. Tivey and Osgood (1950) measured the concentration of 32 P in blood from 1 d to as long as 7 weeks after its intravenous administration to 29 patients with leukemia. A single exponential fit to the full data set yielded a biological half-time of 19 d, but faster clearance was indicated by measurements over the first few days.…”

Section: Summary Of Biokinetic Data For Phosphorusmentioning

confidence: 99%

Proposed biokinetic model for phosphorus

Leggett

2014

J. Radiol. Prot.

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This paper reviews data related to the biokinetics of phosphorus in the human body and proposes a biokinetic model for systemic phosphorus for use in updated International Commission on Radiological Protection (ICRP) guidance on occupational intake of radionuclides. Compared with the ICRP's current occupational model for systemic phosphorus (Publication 68, 1994), the proposed model provides a more realistic description of the paths of movement of phosphorus in the body and greater consistency with experimental, medical, and environmental data regarding its time-dependent distribution. For acute uptake of (32)P to blood, the proposed model yields roughly a 50% decrease in dose estimates for bone surface and red marrow and a six-fold increase in estimates for liver and kidney compared with the model of Publication 68. For acute uptake of (33)P to blood, the proposed model yields roughly a 50% increase in dose estimates for bone surface and red marrow and a seven-fold increase in estimates for liver and kidney compared with the model of Publication 68.

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Section: Summary Of Biokinetic Data For Phosphorusmentioning

confidence: 99%