The biological effects of radiation-induced liver damage and its natural protective medicine

Li, Tianmei; Cao, Yanlu; Li, Bo; Dai, Ruitong

doi:10.1016/j.pbiomolbio.2021.06.012

Cited by 11 publications

(2 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as moKCs can acquire TIM4 with time, the only precise way to distinguish between embryonic and monocyte-derived KCs is through the use of chimeras as recently employed by the Gautier lab (Tran et al, 2020). Of course, this does not come without its own caveats as the irradiation required to generate such chimeras can also influence the integrated-niche and hence liver function and disease progression (Li et al, 2021;Shimura and Kojima, 2014).…”

Section: Recruited Macrophages In the Diseased Livermentioning

confidence: 99%

Liver macrophages in health and disease

2022

View full text Add to dashboard Cite

Section: Recruited Macrophages In the Diseased Livermentioning

confidence: 99%

Liver macrophages in health and disease

2022

View full text Add to dashboard Cite

“…Whole-genome sequencing has been completed for C57BL/6 J mice, confirming that 99% of its genes are homologous to the human genome. This is advantageous for the single-cell sequencing of radiation-induced liver injury and subsequent molecular pathogenesis studies; therefore, it is necessary to establish a suitable mouse model for RILD mechanism studies and exploring intervention strategies [3,4]. Linear accelerators are commonly used medical devices in clinical practice, and the MV radiotherapy system has been sufficiently validated.…”

Section: Introductionmentioning

confidence: 99%

TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

Xiao

Liu

et al. 2023

NUCL SCI TECH

View full text Add to dashboard Cite

The application of a thermoluminescent detector (TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury (RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy (VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume (PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from − 1.5 to 6%; construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.

show abstract

Property of mud and its application in cosmetic and medical fields: a review

Tian

Zhang

et al. 2022

Environ Geochem Health

View full text Add to dashboard Cite

The biological effects of radiation-induced liver damage and its natural protective medicine

Cited by 11 publications

References 66 publications

Liver macrophages in health and disease

Liver macrophages in health and disease

TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

Property of mud and its application in cosmetic and medical fields: a review

Contact Info

Product

Resources

About