The biological effects of acute psychosocial stress on delay discounting

Kimura, Kenta; Izawa, Shuhei; Sugaya, Nagisa; Ogawa, Namiko; Yamada, Kosuke; Shirotsuki, Kentaro; Mikami, Ikuyo; Hirata, Kazuo; Nagano, Yuichiro; Hasegawa, Toshikazu

doi:10.1016/j.psyneuen.2013.04.019

Cited by 67 publications

(50 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests impulsivity, in particular, may only relate to discounting rates in subsamples of individuals. Still other studies have shown that the uncertainty of the future and psychosocial stress can both result in increased delayed discounting (Kimura et al, 2013; Lempert & Pizzagalli, 2010). …”

Section: Clinical Methodsmentioning

confidence: 99%

Assessing anhedonia in depression: Potentials and pitfalls

Rizvi

Pizzagalli

Sproule

et al. 2016

Neuroscience & Biobehavioral Reviews

405

301

View full text Add to dashboard Cite

The resurgence of interest in anhedonia within major depression has been fuelled by clinical trials demonstrating its utility in predicting antidepressant response as well as recent conceptualizations focused on the role and manifestation of anhedonia in depression. Historically, anhedonia has been conceptualized as a “loss of pleasure”, yet neuropsychological and neurobiological studies reveal a multifaceted reconceptualization that emphasizes different facets of hedonic function, including desire, effort/motivation, anticipation and consummatory pleasure. To ensure generalizability across studies, evaluation of the available subjective and objective methods to assess anhedonia is necessary. The majority of research regarding anhedonia and its neurobiological underpinnings comes from preclinical research, which uses primary reward (e.g. food) to probe hedonic responding. In contrast, behavioural studies in humans primarily use secondary reward (e.g. money) to measure many aspects of reward responding, including delay discounting, response bias, prediction error, probabilistic reversal learning, effort, anticipation and consummatory pleasure. The development of subjective scales to measure anhedonia has also increased in the last decade. This review will assess the current methodology to measure anhedonia, with a focus on scales and behavioural tasks in humans. Limitations of current work and recommendations for future studies are discussed.

show abstract

Section: Clinical Methodsmentioning

confidence: 99%

Assessing anhedonia in depression: Potentials and pitfalls

Rizvi

Pizzagalli

Sproule

et al. 2016

Neuroscience & Biobehavioral Reviews

405

301

View full text Add to dashboard Cite

show abstract

“…Although stress hormones impact a number of brain regions related to decision-making [65], the effects of stress on intertemporal choice are inconsistent. One study found that individuals became more impulsive under stress [66], whereas another found that there were no effects [67], and yet another found that these effects depended on individual differences in perceived stress [68]. Therefore, the conditions under which stress influences intertemporal choice remains an open question.…”

Section: Incidental Carryover Effects On Intertemporal Choicementioning

confidence: 99%

The Malleability of Intertemporal Choice

Lempert

Phelps

2016

Trends in Cognitive Sciences

179

158

View full text Add to dashboard Cite

Intertemporal choices are ubiquitous: people often have to choose between outcomes realized at different times. Although it is generally believed that people have stable tendencies toward being impulsive or patient, an emerging body of evidence indicates that intertemporal choice is malleable and can be profoundly influenced by context. How the choice is framed, or the state of the decision-maker at the time of choice, can induce a shift in preference. Framing effects are underpinned by: allocation of attention to choice attributes, reference-dependence and time construal. Incidental affective states and prospection also influence intertemporal choice. We advocate that intertemporal choice models account for these context effects, and encourage the use of this knowledge to nudge people toward making more advantageous choices.

show abstract

“…However, human studies suggest stress can broadly affect decision making, including delay-based reward choice. Anticipation stress interacts with trait perceived stress to alter delay discounting in human volunteers (Lempert et al 2012), and acute psychosocial stress increases delay discounting in individuals who show enhanced cortisol reactivity (Kimura et al 2013). Related studies of risk taking in gambling tasks suggest that acute social or physiological stress can alter risk aversion during decision making (Porcelli et al 2012; Preston et al 2007; van den Bos et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Impaired flexibility in decision making in rats after administration of the pharmacological stressor yohimbine

2014

View full text Add to dashboard Cite

Rationale Stress-induced disruption of decision making has been hypothesized to contribute to drug-seeking behaviors and addiction. Noradrenergic signaling plays a central role in mediating stress responses. However, the effects of acute stress on decision making, and the role of noradrenergic signaling in regulating these effects, have not been well characterized. Objective To characterize changes in decision making caused by acute pharmacological stress, the effects of yohimbine (an α2-adrenergic antagonist) were examined in a delay discounting task. Noradrenergic contributions to decision making were further characterized by examining the effects of propranolol (a β antagonist), prazosin (an αl antagonist), and guanfacine (an α2 agonist). Methods Sprague-Dawley rats were administered drugs prior to performance on a delay discounting task, in which the delay preceding the large reward increased within each session (ascending delays). To dissociate drug-induced changes in delay sensitivity from behavioral inflexibility, drug effects were subsequently tested in a modified version of the discounting task, in which the delay preceding the large reward decreased within each session (descending delays). Results Yohimbine increased choice of the large reward when tested with ascending delays but decreased choice of the same large reward when tested with descending delays, suggesting that drug effects could be attributed to perseverative choice of the lever preferred at the beginning of the session. Propranolol increased choice of the large reward when tested with ascending delays. Prazosin and guanfacine had no effect on reward choice. Conclusions The stress-like effects of yohimbine administration may impair decision making by causing inflexible, perseverative behavior.

show abstract

The biological effects of acute psychosocial stress on delay discounting

Cited by 67 publications

References 42 publications

Assessing anhedonia in depression: Potentials and pitfalls

Assessing anhedonia in depression: Potentials and pitfalls

The Malleability of Intertemporal Choice

Impaired flexibility in decision making in rats after administration of the pharmacological stressor yohimbine

Contact Info

Product

Resources

About