The biological effectiveness of antiproton irradiation

Holzscheiter, M. H.; Bassler, Niels; Agazaryan, Nzhde; Beyer, G.J.; Blackmore, E. W.; DeMarco, John J.; Doser, M.; Durand, Ralph E.; Hartley, Oliver; Iwamoto, Keisuke S.; Knudsen, H.; Landua, R.; Maggiore, C.J.; McBride, William H.; Møller, S.P.; Petersen, J.; Skarsgard, L. D.; Smathers, James B.; Solberg, Timothy D.; Uggerhøj, U. I.; Vranjes, Sanja; Withers, H. Rodney; Wong, Michelle; Wouters, Bradly G.

doi:10.1016/j.radonc.2006.09.012

Cited by 60 publications

(47 citation statements)

References 22 publications

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“…In order to properly compare these results with that of proton therapy, the enhanced RBE for antiprotons in the SOBP must be considered in addition to the physical dose normalized comparisons of Table 2. Using the results from [10] this suggests that the neutron equivalent dose for antiproton therapy is roughly 60 times higher than what is obtained with protons for the given treatment plan. Here it should be noted that most proton therapy centers currently use passive scattering methods for beam delivery which increases the radiation level to the patient by 1-2 orders of magnitude [18].…”

Section: Discussionmentioning

confidence: 91%

“…Initial experiments with 46.7 MeV antiprotons found the biological effective dose ratio (BEDR) between peak and plateau to be 4 times higher for antiprotons than for protons [10]. Recently, we have successfully performed precise measurement of the depth dose profile of antiprotons with ionization chambers [11] and alanine detectors [12], and are therefore now able to extract the relative biological effectiveness (RBE) of antiproton beams from cell survival measurements.…”

Section: Introductionmentioning

confidence: 99%

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Antiproton radiotherapy: peripheral dose from secondary neutrons

et al. 2009

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The AD-4/ACE collaboration studies the biological effects of antiprotons with respect to a possible use of antiprotons in cancer therapy. In vitro experiments performed by the collaboration have shown an enhanced biological effectiveness for antiprotons relative to protons. One concern is the normal tissue dose resulting from secondary neutrons produced in the annihilation of antiprotons on the nucleons of the target atoms. Here we present the first organ specific Monte Carlo calculations of normal tissue equivalent neutron dose in antiproton therapy through the use of a segmented CT-based human phantom. The MCNPX Monte Carlo code was employed to quantify the peripheral dose for a cylindrical spread out Bragg peak representing a treatment volume of 1 cm diameter and 1 cm length in the frontal lobe of a segmented whole-body phantom of a 38 year old male. The secondary neutron organ dose was tallied as a function of energy and organ.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Antiproton radiotherapy: peripheral dose from secondary neutrons

et al. 2009

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“…The idea of using antiprotons in clinical applications goes back to 1984 and 1989 when L.Gray et al [1] proposed antiprotons for radiotherapy and T.Kalogeropoulos et al [2] proposed them for imaging. The scientific interest in the use of antiproton beam for radiotherapy was recently been renewed owing both to their advantageous dosimetric characteristics (the published results about their Relative Biological Effectiveness (RBE) in M H Holzscheiter et al [3] are very promising) and the potential they offer for real time imaging. In this study we investigate the feasibility of real-time imaging during radiotherapy by calculating the energy spectrums.…”

Section: Introductionmentioning

confidence: 99%

On the feasibility of real time imaging in radiotherapy using antiproton beams

Kantemiris¹,

Karaiskos²,

Georgiou³

et al. 2009

J. Inst.

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Antiprotons whose potential in clinical applications has not yet been fully studied and explored, interact in a way similar to the widely used protons. The great advantage of antiprotons over protons is that at the end of their path annihilate and release about 1.88GeV more energy. Although many particles are produced by annihilation most of them escape from the target. Detecting a portion of these particles during patient's irradiation would offer the possibility to monitor the beam in the target in real time. In the current work we investigate the feasibility of real time imaging during radiotherapy by using antiproton beam. In this study a prostate case is simulated using one field and given a typical dose fraction of 2Gy to the target. Monte Carlo code is used to calculate the energy spectrum of the most prominent particles that escape from the target which could be detected outside the patient, as well as the degree of scattering of these particles, as an indication of merit for their use in order to produce an image which represents the absorption of the beam in the target. Results based on these criteria suggest that real time imaging is possible by detecting either charged pions or photons which mainly come from π 0 decays or e + e − annihilation.

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“…Instead the AD-4 collaboration concentrated on measuring the ratio of the biological effect between the peak and plateau area (defined as ''Biological Effective Dose Ratio'', or, ''BEDR''), which is measurable irrespectively of the deposited dose [3]. The BEDR value therefore expresses quantitatively, how much one can reduce the dose in the plateau for a constant effect in the peak.…”

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confidence: 99%

“…Using Monte Carlo calculations for the dose of the primary beam in the peak, it is then possible to provide an estimate of the RBE in the peak region by assuming RBE 01 in the plateau, e.g. in [3] the best estimate of the peak RBE is 2.25 for 20% clonogenic survival of V79 Chinese hamster cells.…”

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confidence: 99%