The biological characters of several strains of vaccinia, cowpox and rabbitpox viruses

Fenner, Frank

doi:10.1016/0042-6822(58)90042-4

Cited by 151 publications

(67 citation statements)

References 27 publications

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“…It would be most useful if tissue culture plaque assays were available which distinguished between parental and mutant types, but McClain's results (1965) indicate that perhaps too many factors need careful control to make such methods reliable routinely. The most reliable method for distinguishing between white pock mutants and their parental types is still intradermal rabbit inoculation (Haddock, 1952;Fenner, 1958).…”

Section: Discussionmentioning

confidence: 99%

“…As well as being of use in confirming clinical diagnosis the pock character is used by those interested in the characteristics and inter-relationships of these viruses. Thus pock character has been used to study spontaneous mutants of cowpox (Haddock, 1952), rabbitpox (Fenner, 1958) and also in genetic recombination (Fenner & Comben, 1958), genetic hybridization and non-genetic reactivation .…”

Section: (Received 21 April 1969)mentioning

confidence: 99%

“…Techniques for measuring the virus content of single pocks, measuring pock diameters and for excision, passage and histology of single pocks were essentially those described by Fenner (1958).…”

Section: General Virological Techniquesmentioning

confidence: 99%

“…40-2 640 D. BAXBY Amount of virus extracted from pocks Fenner (1958) showed that about 10 times more virus could be extracted from disrupted pocks of PCV than from WCV. This was confirmed for PCV and WCV pocks.…”

Section: Size Of Pockmentioning

confidence: 99%

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Variability in the characteristics of pocks produced on the chick chorioallantois by white pock mutants of cowpox and other poxviruses

Baxby

1969

Epidemiol. Infect.

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White pock mutants of cowpox virus produce pocks in the CAM which ‘mimic’ those produced by the parent virus, in macroscopic and microscopic appearance, and in the amount of virus they contain. The proportion of such ‘atypical’ pocks was influenced by the age and source of embryo, incubation temperature and position of the CAM during incubation. Similar results were obtained with white pock mutants isolated from strains of vaccinia, rabbitpox and monkeypox. The appearance of pocks produced by variola, alastrim, ectromelia and vaccinia (Lister) was unaffected by changes in environmental conditions.I would like to thank Professor K. McCarthy, Professor K. R. Dumbell, Dr C. H. Taylor-Robison and Dr C. R. Madeley for their interest and for kindly providing virus strains, and Miss M. Seyfang for technical assistance.I would like to thank the Committee on Research, Liverpool University, for a grant towards the cost of the colour plate.

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Section: Discussionmentioning

confidence: 99%

Section: (Received 21 April 1969)mentioning

confidence: 99%

Section: General Virological Techniquesmentioning

confidence: 99%

Section: Size Of Pockmentioning

confidence: 99%

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Variability in the characteristics of pocks produced on the chick chorioallantois by white pock mutants of cowpox and other poxviruses

Baxby

1969

Epidemiol. Infect.

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“…There are many strains of vaccinia virus which can be distinguished by suitable laboratory tests (Fenner, 1958). There is also accumulating evidence that strains of cowpox virus may be differentiated.…”

Section: Experiments With Other Strains Of Vaccinia and Cowpox Virusmentioning

confidence: 99%

A comparison of the antigens present on the surface of virus released artificially from chick cells infected with vaccinia virus, and cowpox virus and its white pock mutant

Baxby

1972

J. Hyg.

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SUMMARYAntisera prepared against vaccinia and cowpox viruses were absorbed with purified suspensions of vaccinia virus, red cowpox and white cowpox viruses. They were then tested for their ability to neutralize the viruses, and to precipitate the virus soluble antigens.The results showed that some virus specific antigens were not virus surface components and that some components were present on the surface of all three viruses. However, certain components were detected on the surface of vaccinia virus but not on the surface of cowpox virus, and vice versa. Some evidence for the existence of a vaccinia-specific surface component was also obtained.Comparisons between results of cross-neutralization tests and immunodiffusion tests on the absorbed sera indicated that antibody to a number of antigens, including the classical LS, and the cowpox-specific d antigen play no part in the process of poxvirus neutralization.

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Adaptation of variola virus to growth in the rabbit

Dumbell

Bedson

1966

J. Pathol.

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The biological characters of several strains of vaccinia, cowpox and rabbitpox viruses

Cited by 151 publications

References 27 publications

Variability in the characteristics of pocks produced on the chick chorioallantois by white pock mutants of cowpox and other poxviruses

Variability in the characteristics of pocks produced on the chick chorioallantois by white pock mutants of cowpox and other poxviruses

A comparison of the antigens present on the surface of virus released artificially from chick cells infected with vaccinia virus, and cowpox virus and its white pock mutant

Adaptation of variola virus to growth in the rabbit

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