The biological activity of new thieno[2,3-c]pyrazole compounds as anti-oxidants against toxicity of 4-nonylphenol in Clarias gariepinus

Abstract

Graphical abstract

Synthesis, reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3‐c]pyrazole‐5‐carboxamide

“…In the present work, we have reported synthesis of new heterocyclic rings attached or fused to the pyrazolothienopyrimidine moiety. The starting precursor amino thieno[2,3‐ c ]pyrazole carboxamide compound 1 was achieved by the reaction of 5‐chloro‐3‐methyl‐ N ‐phenyl pyrazole‐4‐carbonitrile with elemental sulfur in the presence of sodium borohydride to give the nonisolated sulfanyl sodium salt, which was subjected to react in situ with chloroacetamide followed by Thorpe‐Zeigler cyclization upon heating in ethanolic sodium ethoxide solution . A similar bifunctional thieno[2,3‐ c ]pyrazole ring system has been previously synthesized by Wang et al .…”

“…Furthermore, thienopyrimidines have anticipated biological activity . In the light of the previous biological importance and in our ongoing endeavor to create new pyrazole thienopyrimidine‐based hybrids, we have synthesized here a series of new heterocyclic compounds isoindole, pyrazole, and triazepine attached or fused to the pyrazolothienopyrimidine ring system. Subsequently, due to the resistance of most bacterial and fungal strains to the current antimicrobial therapy, we are interested in synthesizing more effective agents.…”

A Convenient Synthesis, Reactions and Biological Activity of Some New 6H-Pyrazolo[4’,3’:4,5]thieno[3,2-d][1,2,3]triazine Compounds as Antibacterial, Anti-Fungal and Anti-Inflammatory Agents

“…In the present work and in continuation of our program for synthesis of novel pyrazolothienotriazine heterocycles that exhibits biological importance, our synthesis is commenced with the preparation of the required substrate starting material 5, which is a useful intermediate for synthesis of fused pyrazolothienotriazines. 4-Amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile (5) was synthesized by a new method according to literature procedure [28][29][30] (Scheme 1). All attempts to displace the chloride ion by the thiol group in the previously prepared 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (1) by the reaction with thiourea in ethanol, as with other moieties, to obtain 5-mercapto-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (2) failed, giving the chloropyrazole carbonitrile starting material 1.…”

“…In the light of the previous biological importance of pyrazoles and thienopyrazoles, and in continuation of our work for synthesis of new thieno [2,3-c]pyrazoles, [28][29][30] we have synthesized a series of novel pyrazolothienotriazines 6-14. Literature survey revealed that the pyrazolothienotriazine system has not been previously synthesized.…”

Synthesis, Reactions, and Spectral Characterization of New Fused Pyrazolothienopyridine and Pyrazolopyrrolopyridine Systems

“…Our target in this work aims to synthesize fused heterocyclic systems containing thienopyrazolopyridine nucleus. Earlier, we reported the synthesis of pyrazolo[3,4‐ b ]pyridines and their sulfonamide derivatives as antibacterial agents , but recently, we have synthesized thieno[2,3‐ c ]pyrazoles and we have tested them as antimicrobial, anti‐inflammatory and antioxidant against toxicity of 4‐nonylphenol in Clarias gariepinus . Also, some selenolo[2,3‐ c ]pyrazole compounds were synthesized and used as antimicrobial and anti‐inflammatory agents .…”