The Biological Activity of a Novel Pyrethroid: Metofluthrin

Sugano, Masayo; Ishiwatari, Takao

doi:10.1007/128_2011_259

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Biological activity of pyrethrins and pyrethroids. [1][2][3]5,8,9,14,16,22,23,37,[61][62][63][64][65][66][67] 6.4. Environmental behavior of synthetic pyrethroids.…”

Section: Brief Compilation Of Data About Pyrethrins Pyrethroids and Their Constituentsmentioning

confidence: 99%

Pyrethroid insecticides. Chapter I. Synthesis, structure, biochemistry and biosynthesis of pyrethroids

Krief¹

2021

Arkivoc

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The isolation and structure determination of the natural pyrethrins, powerful natural insecticides from the flower-head of Chrysanthemum cinerariifolium, a plant that originates from Dalmatia and Persia, was followed by extensive research work aimed to determine their biosynthetic pathway and, and to discover analogues, the pyrethroids, harmless to mammals, but adapted to fight insects in contextual conditions (indoor, outdoor, soil) and able to be commercialized at affordable cost.

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“…Biological activity of pyrethrins and pyrethroids. [1][2][3]5,8,9,14,16,22,23,37,[61][62][63][64][65][66][67] 6.4. Environmental behavior of synthetic pyrethroids.…”

Section: Brief Compilation Of Data About Pyrethrins Pyrethroids and Their Constituentsmentioning

confidence: 99%

Pyrethroid insecticides. Chapter I. Synthesis, structure, biochemistry and biosynthesis of pyrethroids

Krief¹

2021

Arkivoc

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“…Application of repellents is one technique for prevention and control of mosquitoes and mosquito-borne diseases. Spatial repellents (SR) include a class of volatile pyrethroids, such as transfluthrin and metofluthrin, which have high insecticidal activities (Bibbs et al 2018), high volatility at low temperatures, and low mammalian toxicity (Sugano and Ishiwatari 2012). These features facilitated their use in different commercial mosquito repellent devices (coils, liquid, cold fan vaporizers, paper and resinsbased emanators) against various mosquito vectors, mainly, Ae.…”

Section: Introductionmentioning

confidence: 99%

“…aegypti and Ae. albopictus Skuse (Ujihara et al 2004, Lucas et al 2007, Sugano and Ishiwatari 2012. Paper-based emanators / devices of metofluthrin were highly effective against Aedes and Ochlerotatus species with up to 90% reduction in hostlanding rate (Lucas et al 2007, Xue et al 2012.…”

Section: Introductionmentioning

confidence: 99%

Insecticide Efficacy of Spatial Repellent Compound-Metofluthrin Against Susceptible and Resistant Strains of Aedes Aegypti

Khater¹

2021

J FL Mosq Control Assoc

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Spatial repellents (SR), include pyrethroid insecticides that are highly volatile at low temperatures and with high lethal activities against mosquitoes, mainly Aedes vectors of arboviral diseases. Of these SR, metofluthrin is widely used in various devices for repellent consumer products. This article reports the susceptibility status of Ae. aegypti Puerto Rico permethrin-resistant laboratory strain (PR) and Orlando susceptible laboratory strain (ORL) to metofluthrin and permethrin using the CDC glass bottle bioassay. The time-mortality relationships showed that the permethrin-resistant PR strain is highly resistant to both permethrin and metofluthrin compared to the susceptible ORL strain. The resistant ratio (RR) based on the killing time (KT) (KT50 -PR/KT50 -ORL) was 30- and 5- folds for permethrin and metofluthrin, respectively. The results also showed that the PR strain is less resistance to metofluthrin than to permethrin, with a three-fold RR (KT50 -PR-per/KT50 -PR-met). These results indicate the potential risk of developing cross-resistance of metofluthrin in permethrin-resistant mosquitoes. Integrated vector management in mosquito control should be considerate of how consumer products and field operations interact to accelerate cross resistance to pyrethroids.

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Insecticidal Activity and Expression of Cytochrome P450 Family 4 Genes in Aedes albopictus After Exposure to Pyrethroid Mosquito Coils

et al. 2014

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Mosquito coils are insecticides commonly used for protection against mosquitoes due to their toxic effects on mosquito populations. These effects on mosquitoes could induce the expression of metabolic enzymes in exposed populations as a counteractive measure. Cytochrome P450 family 4 (CYP4) are metabolic enzymes associated with a wide range of biological activities including insecticide resistance. In this study, the efficacies of three commercial mosquito coils with different pyrethroid active ingredients were assessed and their potential to induce the expression of CYP4 genes in Aedes albopictus analyzed by real-time quantitative PCR. Coils containing 0.3 % D-allethrin and 0.005 % metofluthrin exacted profound toxic effects on Ae. albopictus, inducing high mortalities (≥90 %) compared to the 0.2 % D-allethrin reference coil. CYP4H42 and CYP4H43 expressions were significantly higher in 0.3 % D-allethrin treated mosquitoes compared to the other treated populations. Short-term (KT50) exposure to mosquito coils induced significantly higher expression of both genes in 0.005 % metofluthrin exposed mosquitoes. These results suggest the evaluated products provided better protection than the reference coil; however, they also induced the expression of metabolic genes which could impact negatively on personal protection against mosquito.

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The Biological Activity of a Novel Pyrethroid: Metofluthrin

Cited by 9 publications

References 5 publications

Pyrethroid insecticides. Chapter I. Synthesis, structure, biochemistry and biosynthesis of pyrethroids

Pyrethroid insecticides. Chapter I. Synthesis, structure, biochemistry and biosynthesis of pyrethroids

Insecticide Efficacy of Spatial Repellent Compound-Metofluthrin Against Susceptible and Resistant Strains of Aedes Aegypti

Insecticidal Activity and Expression of Cytochrome P450 Family 4 Genes in Aedes albopictus After Exposure to Pyrethroid Mosquito Coils

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