The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

Wang, Weiyou; Sun, Cuixia; Mao, Like; Ma, Peihua; Liu, Fuguo; Yang, Jie; Gao, Yanxiang

doi:10.1016/j.tifs.2016.07.004

Cited by 577 publications

(385 citation statements)

References 233 publications

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“…[10][11][12] It is well known for its DNA protection, anti-inammatory, antiviral, and antibacterial properties, etc. 13,14 Research suggests that eating more fruits and vegetables containing avonols and avanones can reduce the risk of ovarian cancer. The latest research demonstrates that quercetin has a variety of pharmacological activities and its anti-cancer activity can induce tumor cell apoptosis, regulate tumor cell proliferation and tumor angiogenesis, and inhibit the signal pathways of many important targets.…”

Section: -5mentioning

confidence: 99%

Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

Wang

et al. 2018

RSC Adv.

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Ovarian cancer, as one of the killers that threaten women's health, has been studied extensively. As a natural bioflavonoid with prospective effects, quercetin is highly recognized for its anti-cancer applications.However, one of the major challenges that quercetin faces is its poor water solubility, instability in physiological media, and subsequent poor bioavailability. Thus, optimizing the ideal drug delivery options is necessary to facilitate the harnessing of the maximum benefits from quercetin. In this study, a quercetin-loaded thermosensitive injectable hydrogel system (Qu-M-hydrogel composites) was constructed based on nanotechnology. Quercetin was encapsulated into MPEG-PCL (with a high drug loading of 7% and minor particle size of 32 nm) and then added into the blank thermosensitive hydrogel Pluronic F-127. The Qu-M-hydrogel composites showed a much slower release than Qu-M in vivo.Moreover, the cytotoxicity, apoptosis induction, and anti-tumor effects of the Qu-M-hydrogel composites on the abdominal SKOV-3 ovarian cancer mouse models were investigated in vivo. Compared with other groups, the Qu-M-hydrogel composites exhibited improved apoptosis induction and cell growth inhibition effects and in vivo trials showed a better balance between the anti-tumor efficacy in the Qu-M-hydrogel composite group than in other groups at an equal drug dose. In conclusion, the prepared Qu-M-hydrogel composites enhanced the anti-tumor activity by providing a high local quercetin concentration, sustained and stable drug release, extended drug retention inside the tumor, and low toxicity to normal tissues. The Qu-M-hydrogel composites might have great potential for clinical application in anti-ovarian cancer activity.

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Section: -5mentioning

confidence: 99%

Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

Wang

et al. 2018

RSC Adv.

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“…MMDP containing quercetin suppresses the viability of HeLa cells in G2/M phase and induces apoptosis through mitochondrial pathways (Priyadarsini et al, 2010;Dun et al, 2015). The presence of p21 interferes with CDK-cyclin interactions, thereby, inhibiting progression of the cell cycle (Wang et al, 2011). A previous study showed that the MMDP containing quercetin has a potential anti-cancer agent (Endharti et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…MMDP has many benefits in the treatment of various diseases because it contains secondary metabolite compounds, such as quercetin. Quercetin may induce cancer cell death by mediating the expression of the apoptosis receptors and activity (Xavier et al, 2011;Fitrilia et al, 2015;Wang et al, 2016) and survivin expression (Han et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Mango mistletoe Dendrophthoe pentandra leaf extract acts synergistically with 5-Fluorouracil to induce apoptosis and increase p21 expression in human cervical adenocarcinoma HeLa cells by reducing survivin expression

2018

J App Pharm Sci

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Mango mistletoe (Dendrophthoe pentandra L. Miq) (MMDP) leaf extract which contained quercetin inhibits cancer cells. MMDP increasing effectively of 5-Fluorouracil (5-FU) as a chemotherapy agent. This study aimed to investigate the synergistic effects of MMDP combined with 5-FU to determine the percentage of apoptosis, p21, and survivin in HeLa cells. Flow cytometry analysis revealed that it increases apoptosis HeLa cell through increasing p21 and also decreased survivin percentage. The combination of 5-FU 5 µg/ml and MMDP 50 µg/ml significantly increased the percentage of p21 and apoptosis (P < 0.001; P < 0.001) and decreased survivin (P < 0.05) compared with 5-FU only group. This study indicates that the combined 5-FU and MMDP has a synergistic effect to enhance apoptosis and p21 expressions by decreasing of survivin in HeLa cells.

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“…The β‐glucosidase enzyme and lactase phlorizin hydrolase present in the intestinal brush border deglycosylate and absorb quercetin in the aglycone form (Day, Gee, DuPont, Johnson, & Williamson, ). Subsequently, conjugation reactions occur through uridine diphosphate glucuronosyltransferases, catechol‐O‐methyltransferase, and the sulfotransferase and quercetin derivatives––quercetin‐3‐glucuronide, quercetin‐3′‐sulfate, 3′‐O‐methylquercetin (isorhamnetin), and 4′‐O‐methylquercetin––are produced (Wang et al., ).…”

Section: Absorption Metabolism Distribution and Excretionmentioning

confidence: 99%

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei

Mirzababaei

Nassiri‐Asl

2018

Journal of Food Science

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Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer's disease and other types of dementia is necessary.

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The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

Cited by 577 publications

References 233 publications

Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

Mango mistletoe Dendrophthoe pentandra leaf extract acts synergistically with 5-Fluorouracil to induce apoptosis and increase p21 expression in human cervical adenocarcinoma HeLa cells by reducing survivin expression

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

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