“…BDNF interaction with NTRK2 receptor activates three signaling pathways: PI3K-Akt (PI3K, phosphatidylinositol-3 kinase), Ras-MAPK (MAPK, mitogen-activated protein kinase), and PLCγ-Ca + (PLC, phospholipase C; Duman and Voleti, 2012 ). It is also known to regulate a large spectrum of processes of the nervous system, including cell survival, growth, and differentiation ( Casaccia-Bonnefil et al, 1999 ; Bibel and Barde, 2000 ; Huang and Reichardt, 2003 ; Park and Poo, 2013 ; Suliman et al, 2013 ; Zagrebelsky and Korte, 2014 ), synaptic plasticity of neurons, and LTP ( Xu et al, 2000 ; Bramham and Messaoudi, 2005 ; Gottmann et al, 2009 ; Minichiello, 2009 ; Mizui et al, 2014 ; Zagrebelsky and Korte, 2014 ; Leal et al, 2015 ). BDNF’s roles in neuronal processes during development and adulthood, support its potential role in the pathogenesis and treatment of both neurological and psychiatric disorders ( Pruunsild et al, 2007 ; Nagahara and Tuszynski, 2011 ; Weissmiller and Wu, 2012 ).…”