The biologic effect of fibrin-binding synthetic oligopeptide on periodontal ligament cells

Lee, Ju-A; Ku, Young; Park, Yoon-Jeong; Koo, Ki‐Tae; Kim, Tae Il; Seol, Yang‐Jo; Lee, Yong-Moo; Rhyu, In‐Chul; Chung, Chong-Pyoung

doi:10.5051/jkape.2009.39.1.45

Cited by 1 publication

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“…Therefore, small synthetic peptides with active binding sequences of natural proteins have been proposed as alternatives. In our previous study, fibrin- binding synthetic oligopeptide showed marked enhancement in periodontal ligament cell proliferation, attachment, and mineralization [ 30 ]. These results can be compared with those obtained from previous studies conducted by other researchers using similar animal models.…”

Section: Discussionmentioning

confidence: 99%

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Lee

Rhyu

et al. 2010

J Periodontal Implant Sci

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PurposeFibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance bone regeneration in rabbit calvarial defects.MethodsOligopeptides including fibrin-binding sequences of FN repeats were synthesized on the basis of primary and tertiary human plasma FN structures. Peptide coated and uncoated bone minerals were implanted into 10 mm calvarial defects in New Zealand white rabbits, and the animals were sacrificed at 4 or 8 weeks after surgery. After specimens were prepared, histologic examination and histomorphometric analysis were performed.ResultsAt 4 weeks after surgery, the uncoated groups showed a limited amount of osteoid formation at the periphery of the defect and the oligopeptide coated groups showed more osteoid formation and new bone formation in the center of the defect as well as at the periphery. At 8 weeks, both sites showed increased new bone formation. However, the difference between the two sites had reduced.ConclusionsFibrin-binding synthetic oligopeptide derived from FN on deproteinized bovine bone enhanced new bone formation in rabbit calvarial defects at the early healing stage. This result suggests that these oligopeptides can be beneficial in reconstructing oral and maxillofacial deformities or in regenerating osseous bone defects.

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Section: Discussionmentioning

confidence: 99%