The Bioenergetics of Isolated Mitochondria from Different Animal Models for Diabetes

Rendón, Dairo Alonso

doi:10.2174/1573399811666150427163840

Cited by 6 publications

(3 citation statements)

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“…Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetic patients (Nolan et al , 2011). Various animal models have been introduced for the experimental study of T2DM (Rendon, ). The Zucker diabetic fatty (ZDF) rat is one of the animal models of T2DM and is the result of a mutation in the leptin receptor gene (Scarda et al , ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc‐ESI‐Hdms

Dong

Chen

Yang

et al. 2016

Phytotherapy Research

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The present study aimed to evaluate the pathogenesis of type 2 diabetes mellitus (T2DM) and the anti-diabetic effect of berberine in Zucker diabetic fatty (ZDF) rats. A urinary metabolomics analysis was performed with ultra-performance liquid chromatography/electrospray ionization synapt high-definition mass spectrometry. Pattern recognition approaches were integrated to discover differentiating metabolites. We identified 29 ions (13 in negative mode and 16 in positive mode) as 'differentiating metabolites' with this metabolomic approach. A functional pathway analysis revealed that the alterations were mainly associated with glyoxylate and dicarboxylate metabolism, pentose and glucuronate interconversions and sphingolipid metabolism. These results indicated that the dysfunctions of glycometabolism and lipometabolism are involved in the pathological process of T2DM. Berberine could decrease the serum levels of glycosylated hemoglobin, total cholesterol and triglyceride and increase the secretion of insulin. The urinary metabolomics analysis showed that berberine could reduce the concentrations of citric acid, tetrahydrocortisol, ribothymidine and sphinganine to a near-normal state. These results suggested that the anti-diabetic effect of berberine occurred mainly via its regulation of glycometabolism and lipometabolism and activation of adenosine 5'-monophosphate-activated protein kinase. Our work not only provides a better understanding of the anti-diabetic effect of berberine in ZDF rats but also supplies a useful database for further study in humans and for investigating the pharmacological actions of drugs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc‐ESI‐Hdms

Dong

Chen

Yang

et al. 2016

Phytotherapy Research

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“…Many cellular activities such as energy production (ATP), metabolism, homeostasis, the cycle of cell growth, replication and death are controlled by mitochondrial function to keep body work properly [1][2][3]. Mitochondrial disorders caused by effects of oxidative stress from mitochondrial activities can lead to many diseases [4][5][6][7]. Hence, the mitochondria become an attractive potential target for the treatment of various human diseases.…”

Section: Introductionmentioning

confidence: 99%

Development of lipoyl-substituted porphyrins as novel biocompatible mitochondria-targeting agents

Thitimon¹,

Aksornkitti²,

Sereemaspun³

et al. 2022

ScienceAsia

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This work describeed synthesis and investigation of a novel water-soluble lipoyl-substituted porphyrin derivative and its Mn(III)-complex for mitochondria-targeting activities. The freebase derivative was obtained in moderate yield from alkylation of 5,10,15,20-tetra(4-pyridyl)porphyrin followed by amidation with lipoic acid anhydride. Mn-metallation of the freebase derivative quantitatively produced the target Mn(III)-porphyrin. Both lipoyl-substituted porphyrin and Mn(III)-complex were fully characterized by NMR spectroscopy, mass spectrometry, absorption spectrophotometry, and emission spectrophotometry. Both compounds were considered to have low cytotoxicity with IC 50 values of 29-49 and more than 78 µM, respectively, against the HaCaT and HDFa cells. In addition, mitochondria-targeting evaluation suggested that these target porphyrin derivatives exhibited accumulation, specifically in the mitochondria of the HaCaT cells.

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“…Mitochondria were investigated several decades ago when scientists discovered a reduced number of mitochondria in the heart accompanied by mitochondrial swelling and damage to the mitochondrial membranes and cristae in alloxan diabetes [7]. Most studies that aimed to evaluate mitochondrial dysfunction in T1DM were conducted on various experimental animal models (alloxanand streptozotocin-injected animals, as well as depancreatized animals) [8]. Recent reports have revealed disorders within the mitochondria, not only in terms of their counts or morphology [9], but also their function.…”

Section: Introductionmentioning

confidence: 99%

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

Cieluch

Uruska

Zozulińska−Ziółkiewicz

2020

IJMS

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Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.

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The Bioenergetics of Isolated Mitochondria from Different Animal Models for Diabetes

Cited by 6 publications

References 0 publications

Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc‐ESI‐Hdms

Metabolomics Study of Type 2 Diabetes Mellitus and the AntiDiabetic Effect of Berberine in Zucker Diabetic Fatty Rats Using Uplc‐ESI‐Hdms

Development of lipoyl-substituted porphyrins as novel biocompatible mitochondria-targeting agents

Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

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