The biodegradability of polyester blends

Cha, Yong-Jun; Pitt, Colin G.

doi:10.1016/0142-9612(90)90124-9

Cited by 195 publications

(94 citation statements)

References 14 publications

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“…The polymer degradation rate is mainly determined by polymer reactivity with water and catalysts. Any factor which affects the reactivity and the accessibility, such as particle size and shape, temperature, moisture, crystallinity, % isomer, residual lactic acid concentration, Mw, water diffusion and metal impurities from the catalyst, will affect the polymer degradation rate [2,17,[31][32][33]. The in vivo and in vitro degradation have been evaluated for PLA surgical implants.…”

Section: Properties Of Lactic Acid-based Polymersmentioning

confidence: 99%

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Farah

Anderson

Langer

2016

Advanced Drug Delivery Reviews

2,245

1,486

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Available online xxxxPoly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this review is to elaborate the mechanical and physical properties that affect its stability, processability, degradation, PLA-other polymers immiscibility, aging and recyclability, and therefore its potential suitability to fulfill specific application requirements. This review also summarizes variations in these properties during PLA processing (i.e. thermal degradation and recyclability), biodegradation, packaging and sterilization, and aging (i.e. weathering and hygrothermal). In addition, we discuss up-to-date strategies for PLA properties improvements including components and plasticizer blending, nucleation agent addition, and PLA modifications and nanoformulations. Incorporating better understanding of the role of these properties with available improvement strategies is the key for successful utilization of PLA and its copolymers/composites/blends to maximize their fit with worldwide application needs.© 2016 Elsevier B.V. All rights reserved. Contents lists available at ScienceDirectAdvanced Drug Delivery Reviews

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Section: Properties Of Lactic Acid-based Polymersmentioning

confidence: 99%

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

Farah

Anderson

Langer

2016

Advanced Drug Delivery Reviews

2,245

1,486

View full text Add to dashboard Cite

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“…Among United States Food and Drug Administration (FDA)-approved polyesters, poly(ɛ-caprolactone) (PCL) possesses unique properties such as enhanced biocompatibility, higher hydrophobicity, and neutral biodegradation end products that do not disturb the pH balance of the degradation medium (9)(10)(11)(12)(13). Over the years, an array of drug delivery systems has been developed using PCL (14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

et al. 2005

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Purpose.-This study was carried out to determine the biodistribution profiles and tumor localization potential of poly(ethylene oxide) (PEO)-modified poly (β-amino ester) (PbAE) as a novel, pH-sensitive biodegradable polymeric nanoparticulate system for tumor-targeted drug delivery.Methods.-The biodistribution studies of PEO-modified PbAE and PEO-modified poly(ɛ-caplactone) (PCL), a non-pH sensitive polymer, nanoparticle systems were carried out in normal mice using 111 indiumoxine [ 111 In] as a lipophilic radiolabel encapsulated within the polymeric matrix and the distribution of the nanoparticles was studied in plasma and all the vital organs following intravenous administration. Solid tumors were developed on nude mice using human ovarian carcinoma xenograft (SKOV-3) and the change in concentrations of tritium [ 3 H]-labeled paclitaxel encapsulated in polymeric nanoparticles was examined in blood, tumor mass and liver.Results.-Study in normal mice with a gamma-emitting isotope [ 111 In] provided a thorough biodistribution analysis of the PEO-modified nanoparticulate carrier systems, while the 3 H-paclitaxel was useful to understand the change in concentration and tumor localization of anticancer compound directly in major sites of distribution. Both PEO-PbAE and PEO-PCL nanoparticles showed long systemic circulating properties by virtue of surface modification with PEO-containing triblock block copolymer (Pluronic ® ) stabilizer. While the PCL nanoparticles showed higher uptake by the reticuloendothelial system (RES), the PbAE nanoparticles effectively delivered the encapsulated payload into the tumor mass.Conclusions.-PEO-modified PbAE nanoparticles showed considerable passive tumor targeting potential in early stages of biodistribution via the enhanced permeation and retention (EPR) mechanism. This prompts a detailed biodistribution profiling of the nanocarrier for prolonged periods of time to provide conclusive evidence for superiority of the delivery system.

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“…When in contact with the biodegradable polymer, the microorganisms produce enzymes that break down the material in progressively smaller segments; that is to say, they reduce its average molecular mass, favoring its degradation in the environment (Dupret, et al, 1999;Bonhomme et al, 2003;Nakamura et al, 2005). Studies are being conducted to prepare new thermoplastic materials, composed of blends of synthetic polymer with natural polymer, that are degraded more easily when discarded in the environment (Chandra and Rustgi, 1996;Cha and Pitt, 1989;Pedroso and Rosa, 2004). There is great interest in incorporating biodegradable materials such as starch into conventional plastics such as polyethylene (Kim, 2003;Rodriguez-Gonzalez et al, 2003;Matzinos et al, 2002;Baldev et al, 2001).…”

Section: Introductionmentioning

confidence: 99%