2009
DOI: 10.1088/0957-4484/20/42/425103
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The biocompatibility of fluorescent nanodiamonds and their mechanism of cellular uptake

Abstract: The labeling of cells with fluorescent nanoparticles is promising for various biomedical applications. The objective of this study is to evaluate the biocompatibility and the mechanism of the cellular uptake of fluorescent nanodiamonds (FNDs) in cancer cells (HeLa) and pre-adipocytes (3T3-L1). With flow cytometry and the use of a battery of metabolic and cytoskeletal inhibitors, we found that the mechanism of the FND uptake in both cells is by energy-dependent clathrin-mediated endocytosis. In addition, the su… Show more

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Cited by 174 publications
(161 citation statements)
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“…This can be done by atmospheric plasma treatment with nitrogen or hydrogen (Gibson et al 2009), annealing in hydrogen gas (Williams et al 2010) or treatment with NaCl or sodium oleate (Xu et al 2005). Functionalisation with some biomolecules, such as poly-L-lysine (Vaijayanthimala et al 2009) and bovine serum albumin (Yuan et al 2009), can also increase nanodiamond solubility and reduce re-aggregation. The Table 4 Various biological moieties which have been physisorbed to nanodiamonds…”
Section: Oxidation/carboxylation Reductionmentioning
confidence: 99%
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“…This can be done by atmospheric plasma treatment with nitrogen or hydrogen (Gibson et al 2009), annealing in hydrogen gas (Williams et al 2010) or treatment with NaCl or sodium oleate (Xu et al 2005). Functionalisation with some biomolecules, such as poly-L-lysine (Vaijayanthimala et al 2009) and bovine serum albumin (Yuan et al 2009), can also increase nanodiamond solubility and reduce re-aggregation. The Table 4 Various biological moieties which have been physisorbed to nanodiamonds…”
Section: Oxidation/carboxylation Reductionmentioning
confidence: 99%
“…-apoobelin ) -aflatoxin B1 (AfB1) ) -DNA (Fu et al 2007) -luciferase Puzyr' et al 2004) -Alpha-bungarotoxin (Liu et al 2008 (Miller and Brown 1996;Knickerbocker et al 2003;Lu et al 2004;Strother et al 2002;Yang et al 2002;Takahashi et al 2003;Yeap et al 2008;Zhang et al 2009b;Zheng et al 2009;Chang et al 2010) (Strother et al 2002;Takahashi et al 2003;Ida et al 2003;Tsubota et al 2003;Härtl et al 2004;Christiaens et al 2006;Chang et al 2010) (Liu et al 2004;Ando et al 1996b;Khabashesku et al 2005;Ando et al 1996a;Ando et al 1993) (Ando et al 1996a;Ikeda et al 1998;Takahashi et al 2003;Miller and Brown 1996) Silanes Aryl Alkyl Amino (Zhang et al 2009b;Liang et al 2009;Krüger et al 2006;Yeap et al 2008 Zheng et al 2009) choice of biological buffer systems or media is also important, since both foetal bovine serum and phosphate buffered saline, two common biological buffer systems, tend to cause re-aggregation (Neugart et al 2007;Vaijayanthimala et al 2009). Despite the challenges involved in preparing and maintaining de-aggregated nanodiamonds, positive results strongly support their use in biological applications.…”
Section: Oxidation/carboxylation Reductionmentioning
confidence: 99%
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