The biochemistry of white and brown adipocytes analysed from a selection of proteins

Abstract

CONTENTS

Differential Effects of Retinoic Acid on White and Brown Adipose Tissues: An Unexpected Role for Vitamin A Derivatives on Energy Balancea

“…The balance between the development and activity of WAT and BAT determines the overall energy storage of a given individual, and disturbances of this balance are potential causes of obesity. 2…”

“…The balance between the development and activity of WAT and BAT determines the overall energy storage of a given individual, and disturbances of this balance are potential causes of obesity. 2 WAT has long been recognized as a potential site for RA effects. It contains substantial amounts of retinoids, 3 and differentiation of preadipocyte cells into white adipocytes is associated with the accumulation of RA inside the cell.…”

Selective uptake of high density lipoprotein‐associated cholesterylesters by differentiated Ob1771 adipocytes is modulated by endogenous and exogenous lipoprotein lipase

“…For these reasons one might anticipate that other factors than SR‐BI mediate selective HDL‐CE uptake in adipose tissue, a major cholesterol storage compartment in humans. A prominent candidate which could mediate such an effect is lipoprotein lipase (LPL) which is synthesized by adipocytes [16]. Besides its lipolytic activity [17]LPL has been shown to anchor lipoproteins to the surface of a variety of cells [18, 19]thereby increasing surface binding and degradation of lipoproteins [20, 21]by mechanisms involving the low density lipoprotein receptor related protein (LRP) and the very low density lipoprotein (VLDL) receptor [22–24].…”