The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites

Silberberg, Mathieu; Morand, Christine; Mathevon, T; Besson, Catherine; Manach, Claudine; Scalbert, Augustin; Rémésy, Christian

doi:10.1007/s00394-005-0568-5

Cited by 141 publications

(100 citation statements)

References 36 publications

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“…(52) A further explanation may be that those with high intakes of hesperidin may have a greater ability to secrete the metabolites required for its absorption, thus increasing bioavailability. (36) This cross-sectional study of over 3000 women has shown associations between greater intakes of dietary flavonoids and improved bone health, although causality cannot be inferred owing to the study design. To conclude, there are associations between flavonoid intakes and healthy bones, but these associations are not strong and should be considered only as indicators.…”

Section: Discussionmentioning

confidence: 94%

“…The validity study did not use biomarkers because correlations between these and dietary records of flavonoid intakes are not good (r ¼ 0.35) (33) owing to their bioavailability and metabolism in the gut. (34)(35)(36) Limitations of this study include those associated with using an FFQ because FFQs are known to overestimate the true overall frequency of consumption of fruit and vegetables. (37,38) There are issues that affect the flavonoid content of foods, namely, analytical and environmental factors, processing, storage, and species differences, and these cannot be detected using a FFQ because it is a crude measure of diet.…”

Section: Discussionmentioning

confidence: 99%

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Associations between dietary flavonoid intakes and bone health in a scottish population

Hardcastle

Aucott

Reid

et al. 2010

Journal of Bone and Mineral Research

102

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Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of perimenopausal Scottish women. Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study. The diets were analyzed for flavonoid intake using a food composition database. BMD was measured at the femoral neck (FN) and lumbar spine (LS) by dual-energy X-ray absorptiometry (DXA). Free pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high-performance liquid chromatography (HPLC) in second early morning fasted urine samples. The mean flavonoid intake of the diet was 307 AE199 mg/d. The catechin family contributed the most to flavonoid intakes (55%), and the flavones the least (<1%). Associations were found between energy-adjusted total flavonoid intakes and BMD at the FN and LS (FN r ¼ 0.054, LS r ¼ 0.036, p .05). Annual percent change in BMD was associated with intakes of procyanidins and catechins ( p .05), and flavanones were negatively associated with bone-resorption markers (PYD r ¼ À0.049, DPD r ¼ -0.057, p .001). These associations were still seen after adjusting for confounders. It is concluded that dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies. ß

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Associations between dietary flavonoid intakes and bone health in a scottish population

Hardcastle

Aucott

Reid

et al. 2010

Journal of Bone and Mineral Research

102

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“…Only 0.5-0.8% is found in feces of mice (Zhao et al, 2003). After absorption, about 50% of FA reaches the liver, and the remainder is distributed in the bloodstream, gastric mucosa and peripheral tissues (Adam et al, 2002;Zhao et al, 2004;Silberberg et al, 2006). Chang et al (1993) administered pure FA in Wistar rats and found that the free acid did not enter the enterohepatic circulation.…”

Section: Preclinical Pharmacokineticmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

155

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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“…Direct interactions between PCs and other food components, such as bonds with proteins and polysaccharides, and direct effects, such as that of pH, can interfere with the PC absorption by the gut (Silberberg et al, 2006). In relating the results obtained in this study to physiological parameters and the PC bioavailability, we conclude, based on the low levels of adsorption observed, that adsorption of catechin, caffeic acid and ferulic acid by the DFs cellulose and xylan would not compromise their absorption by the intestinal epithelial cells, where most of the phenols are known to be absorbed, especially at a pH close to 7.0 (Dliveira & Bastos, 2011).…”

Section: Physiological Considerationsmentioning

confidence: 99%

“…These compounds include a wide variety of molecules, like phenolic acids, the simplest ones, consisting in a C6-C1 or C6-C3 structure, the flavonoids, which are the most abundant and presenting a C6-C3-C6 structure, and the stilbenes with their C6-C2-C6 structure. The consumption of certain foods may alter the bioavailability of PCs through their direct interaction with others food components, such as proteins and polysaccharides (Manach et al, 2004;Silberberg et al, 2006;D' Archivio et al, 2010). Due to the individual benefits of PCs and DFs, the food and pharmaceutical industries have shown great interest in these bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Adsorption capacity of phenolic compounds onto cellulose and xylan

Costa¹,

Rogez²,

Pena³

2015

Food Sci. Technol (Campinas)

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The interaction between three phenolic compounds (catechin, caffeic acid and ferulic acid) onto two dietary fibres (cellulose and xylan) has been evaluated to inquire possible interferences on the biodisponibility of phenolic compounds. The adsorption kinetics were performed using solutions containing 100 mg/L of phenolic compounds during a contact time ranging between 10 and 120 minutes at pH 2.0, 4.5, and 7.0. After the kinetics, isotherms were obtained using phenolic compounds concentration ranging between 10 and 80 mg/L during 60 minutes, at pH 2.0 and 7.0 and temperature of 36 °C. Results indicate that adsorbed quantities mainly changed in function of pH, however the maximum adsorption was only of 0.978 mg of caffeic acid/g of xylan at pH 2 and after 60 min. Redlich-Peterson model were able to predict the adsorption isotherms of all phenolic compounds onto cellulose, except for caffeic acid at pH 7.0. The low adsorption capacities observed suggest that both dietary fibres are unable to compromise the biodisponibility of phenolic compounds, especially in the small intestine, where they are partially absorbed.

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The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites

Cited by 141 publications

References 36 publications

Associations between dietary flavonoid intakes and bone health in a scottish population

Associations between dietary flavonoid intakes and bone health in a scottish population

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Adsorption capacity of phenolic compounds onto cellulose and xylan

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