The Binding Properties of Antibodies to Z-DNA in the Sera of Normal Healthy Subjects
David S. Pisetsky,
Matthew J. Gedye,
Lawrence A. David
et al.
Abstract:Antibodies to DNA are a diverse set of antibodies that bind sites on DNA, a polymeric macromolecule that displays various conformations. In a previous study, we showed that sera of normal healthy subjects (NHS) contain IgG antibodies to Z-DNA, a left-handed helix with a zig-zig backbone. Recent studies have demonstrated the presence of Z-DNA in bacterial biofilms, suggesting a source of this conformation to induce responses. To characterize further antibodies to Z-DNA, we used an ELISA assay with brominated po… Show more
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