2012
DOI: 10.1016/j.neuint.2012.08.012
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The binding of resveratrol to monomer and fibril amyloid beta

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Cited by 95 publications
(59 citation statements)
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“…In addition, this observation suggested an effect of the reduced amount of Aβ 40 fibrils in solution that could have acted as seeds to catalyze the Aβ 40 aggregation. As the results from this study were in agreement with previous investigations of resveratrol as Aβ -targeting agents for Alzheimer's disease, [57][58][59] EIS proved to be a useful tool to assist in the elucidation of Aβ aggregation in the presence of small molecule modulators. 40 aggregation with Resveratrol.-Aβ 40 aggregation in the presence and absence of resveratrol was also observed using Thioflavin T (ThT) fluorescence ( Figure 4B).…”
Section: Resultssupporting
confidence: 89%
See 1 more Smart Citation
“…In addition, this observation suggested an effect of the reduced amount of Aβ 40 fibrils in solution that could have acted as seeds to catalyze the Aβ 40 aggregation. As the results from this study were in agreement with previous investigations of resveratrol as Aβ -targeting agents for Alzheimer's disease, [57][58][59] EIS proved to be a useful tool to assist in the elucidation of Aβ aggregation in the presence of small molecule modulators. 40 aggregation with Resveratrol.-Aβ 40 aggregation in the presence and absence of resveratrol was also observed using Thioflavin T (ThT) fluorescence ( Figure 4B).…”
Section: Resultssupporting
confidence: 89%
“…Rather, large, amorphous and seemingly porous structures were found ( Figure 5B). These globular species obtained from our experimental conditions were similar to those observed by other groups [59][60][61][62] and were reported to be nontoxic to PC12 neuronal cells. 63,64 TEM results were in agreement with the collected EIS and fluorescence data.…”
Section: Thioflavin T Assay Of Aβsupporting
confidence: 90%
“…Such effects have been reported in various phenolic compounds: flavones such as baicalein (Caruana et al 2012), flavonols such as Myr, quercetin, and morin (Ono et al 2003(Ono et al , 2006a(Ono et al , 2012Masuda et al 2006;Chakraborty et al 2011;Caruana et al 2012;Ho et al 2013), isoflavones such as glycitein and genistein , flavanols such as EGCG and theaflavins (Ono et al 2003(Ono et al , 2006aLevites et al 2003;Rezai-Zadeh et al 2005;Obregon et al 2006;Bastianetto et al 2006;Ehrnhoefer et al 2008;Bieschke et al 2010;He et al 2011;Grelle et al 2011;Cheng et al 2013;Sinha et al 2012;Rushworth et al 2013;Palhano et al 2013;Lorenzen et al 2014), stilbenes such as resveratrol, nordihydroguaiaretic acid (NDGA), piceid, and viniferin (Ono et al 2002(Ono et al , 2003(Ono et al , 2006a(Ono et al , 2012Savaskan et al 2003;Marambaud et al 2005;Rivière et al 2007Rivière et al , 2009Gauci et al 2011;Capiralla et al 2012;Ge et al 2012;Feng et al 2013;Vingtdeux et al 2010;Caruana et al 2012;Rushworth et al 2013;Richard et al 2013), phenolic acids such as rosmarinic acid (RA), tannic acids (TA), ferulic acid (FA), ellagic aci...…”
Section: Studies Using In Vitro Models Of Cerebral Amyloidosismentioning
confidence: 99%
“…Most notably, resveratrol was able to directly interfere with the Aβ aggregation. Resveratrol was proved to directly interact with Aβ monomers and fibrils, inhibit Aβ fibrillization, and convert toxic oligomers into nontoxic species [77,78]. Resveratrol derivatives were also shown to inhibit Aβ42 aggregation by targeting the C-terminus and inhibiting the formation of β-sheets [79].…”
Section: Resveratrolmentioning
confidence: 99%