The Binding of Curcumin to Various Types of Canine Amyloid Proteins

Tei, Meina; Uchida, Kazuyuki; Mutsuga, Mayu; Chambers, James K.; Nakayama, Hiroyuki

doi:10.1292/jvms.11-0420

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…EGCG may increase alpha-secretase processing of APP (47) or decrease BACE protein level (48), thus reducing Aβ production and converting Aβ fibrils into smaller less toxic aggregates (49). Further, curcumin has been shown to bind Aβ plaques in transgenic mice (50) and aged dog brain (51, 52). In mice, curcumin is linked to Aβ reduction through several possible mechanisms including the disaggregation of plaques (50, 53, 54) and attenuating the maturation of the APP (55).…”

Section: Discussionmentioning

confidence: 99%

A Combination Cocktail Improves Spatial Attention in a Canine Model of Human Aging and Alzheimer's Disease

Head

Murphey

Dowling

et al. 2012

JAD

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Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of beta-amyloid (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD. Aged dogs naturally develop learning and memory impairments, human-type Aβ deposits and oxidative damage in the brain. Thus, 9 aged beagles (98-115 months) were treated with a medical food cocktail containing (1) an extract of turmeric containing 95% curcuminoids; (2) an extract of green tea containing 50% epigallocatechingallate; (3) N-acetyl cysteine; (4) R-alpha lipoic acid; and (5) an extract of black pepper containing 95% piperine. Nine similarly aged dogs served as placebo-treated controls. After 3 months of treatment, 13 dogs completed a variable distance landmark task used as a measure of spatial attention. As compared to placebo-treated animals, dogs receiving the medical food cocktail had significantly lower error scores (t(11)=4.3, p=0.001) and were more accurate across all distances (F(1,9)=20.7, p=0.001), suggesting an overall improvement in spatial attention. Measures of visual discrimination learning, executive function and spatial memory, and levels of brain and CSF Aβ were unaffected by the cocktail. Our results indicate that this medical food cocktail may be beneficial for improving spatial attention and motivation deficits associated with impaired cognition in aging and AD.

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Section: Discussionmentioning

confidence: 99%

A Combination Cocktail Improves Spatial Attention in a Canine Model of Human Aging and Alzheimer's Disease

Head

Murphey

Dowling

et al. 2012

JAD

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“…Further, curcumin has been shown to bind with neurofibrillary tangles (NFTs) in human AD Citation: Mait P, Manna J (2014) Activation of Heat Shock Proteins by Nanocurcumin to Prevent Neurodegenerative Diseases. Brain Disord Ther 3: 139. doi:10.4172/2168-975X.1000139 brain and animals [84,85]. It can inhibit tau phosphorylation and aggregation as observed in animal model of AD [74,86].…”

Section: Curcumin Efficacy In Neurodegenerative Disease Therapymentioning

confidence: 99%

Activation of Heat Shock Proteins by Nanocurcumin to Prevent Neurodegenerative Diseases

Manna¹

2014

Brain Disord Ther

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Protein misfolding and its progressive accumulation in central nervous system are the common features and the leading cause of several neurodegenerative diseases. Currently no treatment is available to complete removal of these aggregates and rescue neuronal death, synaptic impairment as well as cognitive deficits. Interesting, the cell itself has a fantastic defense mechanism to remove these aggregates. One such crucial mechanism is molecular chaperones such as heat shock proteins. In general, the larger protein aggregates are removed by this system, and degraded through the proteasome or autophagy pathway. Dysfunction or dysregulation of heat shock system has been observed in several neurological diseases, which severely interfere cellular protein clearance mechanism. Therefore, maintenance or balancing of these endogenous protein clearance pathways is a promising approach to remove these protein aggregates. Several small molecules, drugs, and phytochemicals have been studied to promote the activation of this system. Recently, as a potent anti-amyloid polyphenol, curcumin has drawn special attention for the treatment of several brain disorders including several neurodegenerative diseases. It is effective to boost cellular protein clearance system; therefore, it is considered one of the most promising compounds to rectify dysfunction of heat shock system in these disorders. Whereas, because of its low water solubility and fast degradation, the bioavailability of curcumin is very poor. Using nanotechnology, recently several research groups formulated "nanocurcumin" to improve its bioavailability and significantly increases it's therapeutic efficacy against cancer, but scanty of data are available about it's role on boosting heat shock system to prevent protein misfolding and neurodegeneration. In this review we will discuss the current knowledge about the importance of nanocurcumin and its pivotal role on activation of heat shock system to combat against neurodegenerative diseases caused by protein misfolding.

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