The Biliary Excretion of Various Bile Acids by Patients With Choledochostomy Drainage, and the Effect of Oral Administration of Desiccated Bile of the Ox and the Hog 1

Taurohyodeoxycholic acid is a natural 6 alpha-hydroxylated bile acid with an apparent hydrophilicity intermediate between those of tauroursodeoxycholic and taurocholic acids. We investigated in the rat the hepatobiliary metabolism, choleretic properties, and biliary maximum secretory rate (SRmax) of taurohyodeoxycholic in comparison with these two bile salts. Each compound was infused intravenously, at a rate increased in a stepwise manner from 100 to 300 nmol/min/100 g body wt, in bile salt-depleted bile fistula rats. The three bile salts appeared rapidly starting with the infusion and increased to represent more than 95% of the total bile salts. No apparent biliary metabolites were formed. All the bile salts caused a dose-dependent increase in bile flow and biliary lipid output. The absolute increase in bile flow was lower in rats infused with taurohyodeoxycholic acid, yet the volume of bile formed per nanomole of secreted bile salt was 13.8 nl for taurohyodeoxycholic, 6.4 nl for tauroursodeoxycholic acid, and 10.9 nl for taurocholic. The SRmax values were 1080, 3240, and 960 nmol/min/100 g, respectively. At all infusion rates, taurohyodeoxycholic acid caused a greater (P < 0.001) secretion of biliary lecithin compared to the other bile salts. There were no significant differences in the biliary secretion of cholesterol and proteins. Electron microscopy showed the recruitment of vesicles and lamellar bodies around and within bile canaliculi. In conclusion, taurohyodeoxycholic promotes a biliary lecithin secretion greater than expected from physicochemical predictions, representing a novel secretory property with potential pharmacological relevance.

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Induced Alterations in Composition of Bile of Persons Having Cholelithiasis

Thistle¹,

Schoenfield²

1971

Gastroenterology

194

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The Biliary Excretion of Various Bile Acids by Patients With Choledochostomy Drainage, and the Effect of Oral Administration of Desiccated Bile of the Ox and the Hog 1

Cited by 5 publications

References 12 publications

Solubility of Cholesterol and Gallstones in Metabolic Material

Solubility of Cholesterol and Gallstones in Metabolic Material

Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat

Induced Alterations in Composition of Bile of Persons Having Cholelithiasis

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