The Biliary Excretion of Furadantin

Twiss, John Russell; Berger, William V.; Aronson, Allan R.; Gillette, Lee; Siegel, Louis

doi:10.1016/s0016-5085(56)80010-3

Cited by 4 publications

(1 citation statement)

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“…The nitrofurantoin levels in the bile and blood were less than 5 per cent of those noted by Twiss and associates. 1 In no instance have we been able to eradicate infection in the biliary tract, although in many cases the infecting organism was highly sensitive to nitrofurantoin when tested by the standard paper-disc method. In the first case reported, nitrofurantoin was ineffective both clinically and bacteriologically.…”

Section: Discussionmentioning

confidence: 99%

Nitrofurantoin (Furadantin) in the biliary tract

Feder

Kahn

Flores

et al. 1960

Clin Pharma and Therapeutics

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Twiss and his co‐worker's reported that the oral administration of nitrofurantoin produced bactericidal levels of the drug in the bile. The organisms which infect the biliary tract are frequently the same as those which infeet the urinary tract. They therefore inferred that nitrofurantoin should be a valuable agent in treating infections of the biliary tract. We were unable to eradicate infections in the biliary tract even though the organisms isolated from culture of the bile were sensitive to the action of nitrofurantoin in vitro. Therefore we decided to repeat the studies of Twiss and his associates. Following the oral administration of adequate doses of nitrofurantoin, the levels of this drug were studied in bile specimens obtained trom the gall bladder by T‐tube drainage and duodenal tube drainage. Blood levels were also determined. Nitrofurantoin levels were far below those obtained by Twiss. In no instance was there any bactericidal activity of nitrofurantoin observed at levels present in the bile during treatment. Nitrofurantoin is therefore ineffective in treatment oi infections of the biliary tract.

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Section: Discussionmentioning

confidence: 99%