The bile acid binding and hypocholesterolemic action of two water-soluble polymers

Kuron, Gunther W.; Grier, Nathaniel; Huff, Jesse W.

doi:10.1016/0021-9150(80)90139-2

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Our study demonstrates that the taurocholate binding capacity of Questran was approximately one-third of that reported by other investigators.'."J.1*. 13 The bile salt binding capacity of Questran measured by our methods was -20-40-fold higher than that of Carafate and 40-fold higher than that of Maalox, and could be due to some of the other ingredients present in Questran. 14 To determine the physiologic significance of' bile salt binding by these commonly used GI drugs, three parameters must be considered: (1) the size of the bile salt pool; (2) the usual daily dose of these agents; and (3) the bile salt binding capacity of the drug.…”

Section: Discussionmentioning

confidence: 71%

Bile Salt Binding Properties of Commonly Used Gastrointestinal Drugs: Maalox, Carafate, and Questran

Shiau

Schenkein

Liu

et al. 1988

Journal of Pharmaceutical Sciences

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Section: Discussionmentioning

confidence: 71%

Bile Salt Binding Properties of Commonly Used Gastrointestinal Drugs: Maalox, Carafate, and Questran

Shiau

Schenkein

Liu

et al. 1988

Journal of Pharmaceutical Sciences

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“…Other approaches involve the polymerization of secondary or primary diamines under very mild conditions followed by reaction to produce quaternized amines after polymerization. When desired, cross-linking is often accomplished after the initial polymer structure has been formed …”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Novel Poly(alkylamine)-Based Hydrogels Designed for Use as Bile Acid Sequestrants

et al. 1997

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Preparation of novel poly(alkylamine)-derived hydrogels is described. Polymers are prepared via reaction of various diamines with dihalo compounds or diepoxides. N-substituted polymers are readily prepared by reaction of primary amines with dihalo compounds. The resulting covalently cross-linked polymers exhibit hydrogel behavior (high swell with water) when ionized to polyammonium species at low pH. At high pH, the polymers reside in the free base polyamine form and lose all hydrogel character (they no longer swell in water). Characterization of polymer structure with carbon-13 NMR, thermal analysis, and swell behavior reveals a structure which is highly branched and only loosely cross-linked. In the ionic polyammonium form thermal stability up to ∼300 °C is observed. The polymers exhibit activity as bile acid sequestrants significantly superior to cholestyramine, as evidenced by their ability to efficiently bind quantities of cholate when tested in vitro. This behavior indicates that these hydrogels should be very useful for the treatment of hypercholesterolemia.

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Polymeric Sorbents for Bile Acids. I: Comparison between Cholestyramine and Colestipol

Zhu

Brown

St-Pierre

1992

Journal of Pharmaceutical Sciences

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The bile acid binding and hypocholesterolemic action of two water-soluble polymers

Cited by 7 publications

References 19 publications

Bile Salt Binding Properties of Commonly Used Gastrointestinal Drugs: Maalox, Carafate, and Questran

Bile Salt Binding Properties of Commonly Used Gastrointestinal Drugs: Maalox, Carafate, and Questran

Preparation and Characterization of Novel Poly(alkylamine)-Based Hydrogels Designed for Use as Bile Acid Sequestrants

Polymeric Sorbents for Bile Acids. I: Comparison between Cholestyramine and Colestipol

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