The bile acid‐activated retinoic acid response in dendritic cells is involved in food allergen sensitization

Wu, Renlan; Yuan, Xiefang; Li, Xingjie; Ma, Ning; Jiang, Hongyu; Tang, Hongmei; Xu, Guofeng; Liu, Zhigang; Zhang, Zongde

doi:10.1111/all.15039

Cited by 25 publications

(22 citation statements)

References 71 publications

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“…Bacterial modified secondary bile acids, such as deoxycholic acid and lithocholic acid, are FXR agonists, while supernatants from in vitro bacterial cultures also possess FXR ligands 178,179 . FXR‐RARα signalling in murine mucosal dendritic cells supported food allergen‐specific IgE and IgG1 production, while allergic diarrhoea can be attenuated by FXR agonists due to their antisecretory effects in colonic epithelial cells 180,181 . Ursodeoxycholic acid treatment of OVA‐sensitized mice prior to OVA aerosol challenge significantly reduced eosinophilic airway inflammation via FXR signalling in dendritic cells 182 .…”

Section: Nuclear Receptorsmentioning

confidence: 99%

“… 178 , 179 FXR‐RARα signalling in murine mucosal dendritic cells supported food allergen‐specific IgE and IgG1 production, while allergic diarrhoea can be attenuated by FXR agonists due to their antisecretory effects in colonic epithelial cells. 180 , 181 Ursodeoxycholic acid treatment of OVA‐sensitized mice prior to OVA aerosol challenge significantly reduced eosinophilic airway inflammation via FXR signalling in dendritic cells. 182 Similarly, the FXR ligand chenodeoxycholic acid attenuates murine allergic airway inflammation by inhibiting TH2 cytokine secretion.…”

Section: Nuclear Receptorsmentioning

confidence: 99%

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Immunomodulation by foods and microbes: Unravelling the molecular tango

Forde

Shaha

et al. 2022

Allergy

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Metabolic health and immune function are intimately connected via diet and the microbiota. Nearly 90% of all immune cells in the body are associated with the gastrointestinal tract and these immune cells are continuously exposed to a wide range of microbes and microbial‐derived compounds, with important systemic ramifications. Microbial dysbiosis has consistently been observed in patients with atopic dermatitis, food allergy and asthma and the molecular mechanisms linking changes in microbial populations with disease risk and disease endotypes are being intensively investigated. The discovery of novel bacterial metabolites that impact immune function is at the forefront of host‐microbe research. Co‐evolution of microbial communities within their hosts has resulted in intertwined metabolic pathways that affect physiological and pathological processes. However, recent dietary and lifestyle changes are thought to negatively influence interactions between microbes and their host. This review provides an overview of some of the critical metabolite‐receptor interactions that have been recently described, which may underpin the immunomodulatory effects of the microbiota, and are of relevance for allergy, asthma and infectious diseases.

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Section: Nuclear Receptorsmentioning

confidence: 99%

Section: Nuclear Receptorsmentioning

confidence: 99%

Immunomodulation by foods and microbes: Unravelling the molecular tango

Forde

Shaha

et al. 2022

Allergy

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“…Secondary bile acids have also been demonstrated to induce the expression of the transcription factor Foxp3, as well as the production of RORγ+ regulatory T-cells [ 98 , 99 , 100 ]. A recent study demonstrated a mechanism of food sensitization via bile acid-mediated activation of retinoic acid responsive element in dendritic cells, thereby promoting food-allergen specific IgE and IgG1 [ 101 ]. The role of bile acids in regulating immunological and inflammatory responses is complex, and continued studies will help elucidate their role in the development of therapeutic approaches to food allergies.…”

Section: Metabolitesmentioning

confidence: 99%

Microbiome Therapeutics for Food Allergy

2022

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The prevalence of food allergies continues to rise, and with limited existing therapeutic options there is a growing need for new and innovative treatments. Food allergies are, in a large part, related to environmental influences on immune tolerance in early life, and represent a significant therapeutic challenge. An expanding body of evidence on molecular mechanisms in murine models and microbiome associations in humans have highlighted the critical role of gut dysbiosis in the pathogenesis of food allergies. As such, the gut microbiome is a rational target for novel strategies aimed at preventing and treating food allergies, and new methods of modifying the gastrointestinal microbiome to combat immune dysregulation represent promising avenues for translation to future clinical practice. In this review, we discuss the intersection between the gut microbiome and the development of food allergies, with particular focus on microbiome therapeutic strategies. These emerging microbiome approaches to food allergies are subject to continued investigation and include dietary interventions, pre- and probiotics, microbiota metabolism-based interventions, and targeted live biotherapeutics. This exciting frontier may reveal disease-modifying food allergy treatments, and deserves careful study through ongoing clinical trials.

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“…Considering that low vitamin D is related to the development of food allergy ( 57 ), the mechanism of which is involved with ILCs ( 58 ), the balance between vitamins A and D might be an important factor in the ILCs-related diseases like IBD. Meanwhile, gut-dysbiosis-induced dysregulated bile acids (BAs) induce enhancement of RA signaling in mucosal DCs, leading to food allergen-specific IgE and IgG1 ( 59 ), implying that BA-RA signaling may change Th2 cells prime DCs.…”

Section: Introductionmentioning

confidence: 99%

Modulation by luminal factors on the functions and migration of intestinal innate immunity

Higashiyama

Miura²,

Hokari³

2023

Front. Immunol.

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Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and intestinal allergy. Luminal factors are sensed by distinct neuro-immune cell units, which also have a strong impact on immunoregulation of the gut. Immune cell trafficking from the blood stream through the lymphatic organ to lymphatics, an essential function for immune responses, is also modulated by luminal factors. This mini-review examines knowledge of luminal and neural factors that regulate and modulate response and migration of leukocytes including innate immune cells, some of which are clinically associated with pathological intestinal inflammation.

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The bile acid‐activated retinoic acid response in dendritic cells is involved in food allergen sensitization

Cited by 25 publications

References 71 publications

Immunomodulation by foods and microbes: Unravelling the molecular tango

Immunomodulation by foods and microbes: Unravelling the molecular tango

Microbiome Therapeutics for Food Allergy

Modulation by luminal factors on the functions and migration of intestinal innate immunity

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