The “biker-glove” pattern of segmental infantile hemangiomas on the hands and feet

Weitz, Nicole A.; Bayer, Michelle L.; Baselga, Eulàlia; Torres, Mauricio; Siegel, Dawn H.; Drolet, Beth A.; Frieden, Ilona J.; Haggstrom, Anita N.

doi:10.1016/j.jaad.2014.04.062

Cited by 24 publications

(27 citation statements)

References 15 publications

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“…Between 27%‐38% of the segmental IH located in the extremities are IH‐MAG . Most of them have a reticular morphology, with visible and prominent surface telangiectasia.…”

Section: Discussionmentioning

confidence: 99%

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Martín

Sánchez

González

et al. 2018

Pediatric Dermatology

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Background/objectives Infantile hemangiomas (IH) with minimal or arrested growth (MAG) constitute a distinctive subset of IH based on their clinical characteristics and natural history. They are often confused with capillary malformations. Methods A retrospective observational study has been carried out in which clinical and perinatal characteristics have been evaluated in all IH‐MAG evaluated in our Dermatology Department in a 5‐year period (January 2013‐December 2017). Results A total of 14 IH‐MAG affecting 13 patients were identified (10 girls and 3 boys). All were born full term, with a mean birth weight of 3448 g for girls vs 3540 g for boys, corresponding to the 72nd percentile for both sexes. The IH‐MAG was noticed at birth in 75% of cases. It had a segmental distribution in 6 cases and focal in 8. The most common clinical features was the presence of an erythematous or reticulated background and superficial red bright papules. Lesions were located preferentially in the lower body. Doppler ultrasound showed no significant vascular abnormalities in any case. Five IH‐MAG developed ulcerations and three required treatment with propranolol. Progressive involution was observed in all cases. Conclusions In spite of being a true IH, the absence of a relationship with prematurity, the high birth weight of the newborns, the predominance on the extremities, the higher percentage of segmental lesions, and their reduced ability to proliferate suggest possible etiopathogenic differences compared with conventional IH.

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“…Between 27%‐38% of the segmental IH located in the extremities are IH‐MAG . Most of them have a reticular morphology, with visible and prominent surface telangiectasia.…”

Section: Discussionmentioning

confidence: 99%

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Martín

Sánchez

González

et al. 2018

Pediatric Dermatology

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“…It is characterized by severe complications including intractable ulceration, tissue, and bone destruction. Additionally it can be associated with structural anomalies [8, 11]. Ulceration was a common finding in our group.…”

Section: Discussionmentioning

confidence: 74%

Different Clinical Features of Acral Abortive Hemangiomas

Gutiérrez

Allende

et al. 2017

Case Reports in Dermatological Medicine

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Some infantile hemangiomas called in literature “minimal or arrested growth hemangiomas” or “abortive hemangiomas” are present at birth and have a proliferative component equaling less than 25% of its total surface area. Often, they are mistaken for vascular malformation. We present five patients (three girls and two boys) with abortive hemangiomas diagnosed between January 2010 and December 2015 localized in acral part of the extremities. They were congenital lesions resembling precursor of hemangiomas but did not show proliferation phase. Immunohistochemical Glut-1 was performed in all of them as a way to confirm the abortive hemangioma diagnosis. The most common appearance was a reticulated erythematous patch with multiple fine telangiectasias on the surface. We remark that one of them presented a segmental patch with two different morphologies and evolutions. The proximal part showed pebbled patches of bright-red hemangioma and presented proliferation and the distal part with a reticulated network-like telangiectasia morphology remained unchanged. We detected lower half of the body preference and dorsal region involvement preference without ventral involvement. The ulceration occurred in three patients with two different degrees of severity.

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“…Although controversial, reports of an association between CMN and IH could lend support to this theory . When the biker‐glove pattern was first described in IH, it was hypothesized that the event leading to this pattern would have to occur after the formation of finger rays but before the interweb spaces are completely developed . The pathogenesis in CMN seems to differ slightly, in that an earlier causative event is hypothesized that still spares the distal digit because the distal digit is supplied by a separate, yet unidentified precursor.…”

Section: Discussionmentioning

confidence: 99%

“…A “biker‐glove” pattern of acral infantile hemangiomas (IH) has been described, characterized by extension onto the fingers and toes with a contiguous border across digits and sparing of the distal tips . This pattern did not correspond to known embryonic segments, sensory nerve distributions, dermatomes or lines of Blaschko.…”

Section: Introductionmentioning

confidence: 99%

“…This pattern did not correspond to known embryonic segments, sensory nerve distributions, dermatomes or lines of Blaschko. It was hypothesized that for the biker‐glove pattern to arise, the developmental error giving rise to IH must occur between 38 and 52 days gestation, after the finger rays are formed but before the interweb spaces are completely developed and the distal digits have differentiated …”

Section: Introductionmentioning

confidence: 99%

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The biker‐glove pattern of congenital melanocytic nevi

Kittler

Mathes

Kinsler

et al. 2019

Pediatric Dermatology

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Congenital melanocytic nevi (CMN) are common birthmarks with 20% occurring on the limbs. We describe 4 patients with acral CMN with a “biker‐glove” distribution with sparing of the distal digits, as has previously been described in acral infantile hemangiomas (IH). The existence of the biker‐glove pattern suggests that CMN arise from early mutations in melanocyte precursors and supports the recently described Kinsler‐Larue hypothesis of mesenchymal distribution of melanocyte migration occurring in a circular field from a central point. Developmental errors in mesenchymal precursors with similar migration patterns may explain this shared pattern among CMN and IH.

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The “biker-glove” pattern of segmental infantile hemangiomas on the hands and feet

Cited by 24 publications

References 15 publications

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Different Clinical Features of Acral Abortive Hemangiomas

The biker‐glove pattern of congenital melanocytic nevi

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