The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Meyer, D.; Stasse-Wolthuis, M.

doi:10.1038/ejcn.2009.64

Cited by 274 publications

(189 citation statements)

References 93 publications

(95 reference statements)

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“…Food artificially enriched with these fibers has been termed a prebiotic when it is able to shift the composition of gut microbiota by stimulating the growth or activity of beneficial species (23). In this respect, carbohydrate-fermenting bacteria such as Bifidobacteria and Lactobacilli increase upon prebiotic treatment in different age-groups (62). The effects of prebiotics have been ascribed to an immune-mediated mechanism.…”

Section: Innovative Strategies For Novel Therapeutics In T2dmmentioning

confidence: 99%

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

et al. 2014

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The worldwide prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise at an alarming pace. Recently the potential role of the gut microbiome in these metabolic disorders has been identified. Obesity is associated with changes in the composition of the intestinal microbiota, and the obese microbiome seems to be more efficient in harvesting energy from the diet. Lean male donor fecal microbiota transplantation (FMT) in males with metabolic syndrome resulted in a significant improvement in insulin sensitivity in conjunction with an increased intestinal microbial diversity, including a distinct increase in butyrate-producing bacterial strains. Such differences in gut microbiota composition might function as early diagnostic markers for the development of T2DM in high-risk patients. Products of intestinal microbes such as butyrate may induce beneficial metabolic effects through enhancement of mitochondrial activity, prevention of metabolic endotoxemia, and activation of intestinal gluconeogenesis via different routes of gene expression and hormone regulation. Future research should focus on whether bacterial products (like butyrate) have the same effects as the intestinal bacteria that produce it, in order to ultimately pave the way for more successful interventions for obesity and T2DM. The rapid development of the currently available techniques, including use of fecal transplantations, has already shown promising results, so there is hope for novel therapies based on the microbiota in the future.

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Section: Innovative Strategies For Novel Therapeutics In T2dmmentioning

confidence: 99%

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

et al. 2014

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“…Supplements of inulin or oligofructose increase gastrointestinal concentrations of bifidobacteria (Meyer and Stasse-Wolthuis, 2009), and they may positively influence appetite (Cani et al, 2009), immune function (Lomax and Calder, 2009) and mineral absorption (Scholz-Ahrens et al, 2007). Despite these effects, high intakes can induce gastrointestinal symptoms, including mild flatulence and borborygmi (Bruhwyler et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Validation of a food frequency questionnaire to measure intakes of inulin and oligofructose

et al. 2010

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Background and objectives: Inulin and oligofructose are prebiotic carbohydrates associated with numerous health benefits. The aim of this study was to accurately measure inulin and oligofructose intakes and to develop and validate a food frequency questionnaire (FFQ). Subjects and methods: A 7-d semi-weighed food diary (FD) was used to measure intakes in 66 healthy subjects. A 23-item FFQ was developed to measure short-term inulin and oligofructose intakes over the same 7 days and was completed twice on 2 separate days. Results: There were no significant differences in inulin intake (4.0±1.3 vs 4.0±1.4 g/d, P ¼ 0.646) or oligofructose intake (3.8 ± 1.2 vs 3.8 ± 1.3 g/d, P ¼ 0.864) when measured using the 7-d FD or the FFQ. Bland-Altman analysis demonstrated low mean differences between the FD and FFQ in measuring intakes of inulin (À0.09 g/d) and oligofructose (À0.03 g/d). The FFQ categorised 89% of subjects into the same or adjacent tertiles of intakes as the 7-d FD. For the majority of food items, kappa values indicated 'substantial' or 'almost perfect' agreement for assignment of 'portion size' and 'frequency of consumption' between the FFQs completed on separate days. Conclusions: The FFQ is a valid and reliable method for measuring short-term inulin and oligofructose intakes for use in dietary surveys and clinical trials.

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“…In addition, the development of bifidobacteria is detrimental to the growth of harmful pathogens, and FOS is therefore considered a prebiotic. These beneficial properties help modulating bowel functions and improve defecation frequency (9)(10)(11).…”

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confidence: 99%

Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2016

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♦ Background: Fructo-oligosaccharides (FOS) exhibit soluble-fiber properties that beneficially affect bowel function and relieve constipation. The effects of FOS supplementation on constipation and biochemical parameters were examined in elderly continuous ambulatory peritoneal dialysis (CAPD) patients. ♦ Methods: This randomized, double-blind, placebocontrolled, cross-over study was performed in elderly CAPD patients (5 males and 4 females) with chronic constipation. All subjects were randomly assigned to receive either 20 g FOS or placebo daily for 30 days. After a 14-day washout period, the patients were switched to the other substance for 1 more month. Before and after each treatment period, frequency of defecation, characteristics of feces, and colonic transit were evaluated. Biochemical parameters were also assessed. ♦ Results: Fructo-oligosaccharides significantly increased the frequency of defecation (10.5 ± 2.0 vs 6.2 ± 1.4 times per week, p < 0.005) and changed the feces' appearance from type 1 (nut-like) to type 4 (sausage-like). The colonic transit determined by geometric center (GC) was augmented after FOS supplementation (3.9 ± 0.3 vs 3.2 ± 0.4, p < 0.05). Fructo-oligosaccharides had no effects on biochemical parameters. Fructo-oligosaccharides caused mild discomforts which were well tolerated after dose adjustment. ♦ Conclusions: Fructo-oligosaccharide supplementation is effective, well tolerated, and can be an alternative to other laxatives in CAPD patients with constipation. Further studies are needed to better assess the biochemical effects of FOS in the chronic kidney disease population.

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The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Cited by 274 publications

References 93 publications

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

Validation of a food frequency questionnaire to measure intakes of inulin and oligofructose

Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

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