The bidirectional relationship between metabolic syndrome and hyperuricemia in China: A longitudinal study from CHARLS

Chen, Wenyu; Fu, Yanpeng; Zhou, Min

doi:10.1007/s12020-022-02979-z

Cited by 19 publications

(18 citation statements)

References 28 publications

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“…Some studies suggest that MetS can increase the incidence of hyperuricemia ( 19 – 21 ); however, others suggest that hyperuricemia should be included as a component of MetS ( 7 ). The latest study that reviewed the China Health and Retirement Longitudinal Study (CHARLS) data from 2011 to 2015 concluded that there is a bidirectional relationship between MetS and hyperuricemia, which is in agreement with our research ( 9 ). In our study, the OR of female hyperuricemia patients with MetS was greater than that of males, which is in line with the study of American scholar Sui and Turkish scholar Onat et al.…”

Section: Discussionsupporting

confidence: 91%

“…The association between hyperuricemia and MetS has been explored in many cross-sectional studies, but prospective studies are rare ( 7 – 9 , 19 , 20 ). Some studies suggest that MetS can increase the incidence of hyperuricemia ( 19 – 21 ); however, others suggest that hyperuricemia should be included as a component of MetS ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…Both hyperuricemia and MetS are common chronic diseases, and studies have indicated that hyperuricemia and MetS are closely related ( 7 – 9 ). A cross-sectional study indicated that hyperuricemia was an important factor in MetS, but it was not discussed individually in men and women ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, cross-sectional studies cannot analyze cause and effect very well. A prospective study with up to 4.5 years of follow-up explored the relationship between new-onset MetS and hyperuricemia and suggested a bidirectional effect ( 9 ). However, the role of hyperuricemia in the recovery of MetS is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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ObjectiveThis study was a prospective assessment of the epidemiological characteristics of metabolic syndrome (MetS) in cities in Northeast China. We explored the factors that affect the occurrence and outcome of MetS according to sex.Design and MethodsThis was a longitudinal survey assessing MetS status among 750 urban community residents in China. At baseline, the intra-abdominal fat area was measured by MRI, simple anthropometric parameters (body mass index (BMI), waist circumference (WC), etc.) were used to evaluate fat distribution; blood pressure and blood lipid profile were measured; an oral glucose tolerance test (OGTT) was used to detect blood glucose; questionnaires were used to investigate lifestyles. Follow-up was conducted after 1.5 years (follow-up rate was 66.93%) to analyze the incidence of MetS and the influencing factors of MetS outcomes according to sex.ResultsThe 1.5-year cumulative incidence of MetS in the survey area was 25.40%. Men with visceral obesity were more likely to develop MetS than those with subcutaneous obesity (OR=9.778, p<0.05). Increased BMI (OR=1.379) and blood uric acid (BUA)>416 mmol/L (OR=2.318) were associated with the occurrence of MetS in men (all p<0.05). At the initial visit, BUA>356.9 mmol/L (OR=3.538), increased BMI (OR=1.212), and increased HbA1c (OR=2.577) were associated with the occurrence of MetS in women (all p<0.05). After 1.5 years, 25.37% of MetS patients no longer had MetS. Elevated diastolic blood pressure (DBP) (OR=1.097) and increased visceral fat (OR=1.023) at the initial visit made men with MetS less likely to recover from MetS (all p<0.05). Higher High-density lipoprotein cholesterol (HDL-C) at the initial visit made women with MetS more likely to recover from MetS (β: -3.509, OR=0.003, p<0.05).ConclusionThere are different risk factors for MetS in different genders. Hyperuricemia is a risk factor for the onset of MetS in both men and women.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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“…According to epidemiological surveys, the prevalence of HUA in Chinese adults remarkably rises from 8.4% in 2009–2010 to 14.0% in 2018–2019, and also more than 20.0% from 2007 to 2016 in United States ( 7 , 8 ). Although the serum UA level is not a diagnostic criterion for MetS, longitudinal studies have demonstrated that HUA is closely associated with the development of MetS and its components, and there is a bidirectional relationship between them ( 9 , 10 ). The morbidity of MetS gradually raises with the growth of serum UA level ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury

et al. 2022

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Ferulic acid is a well-known phenolic acid compound and possesses multiple health-promoting and pharmacological effects. Metabolic syndrome (MetS) and hyperuricemia (HUA) have become health problems worldwide and are closely connected. The aim of this study was to explore the influence of ferulic acid on MetS-related HUA and its underlying mechanisms. Rats were administered high-fructose and high-fat diet (HFFD) with or without ferulic acid (0.05 and 0.1%) for 20 weeks. Intake of HFFD resulted in obesity, hyperglycemia, insulin resistance, and dyslipidemia, which were alleviated by ferulic acid consumption. Treatment of rats with ferulic acid diminished the levels of lipids and inflammatory cytokines and enhanced the activities of antioxidant enzymes in the liver caused by HFFD. Additionally, administration of ferulic acid blocked a HFFD-induced elevation in activities and mRNA expression of enzymes involving in uric acid (UA) synthesis. Molecular docking analysis denoted that ferulic acid bound to the active center of these enzymes, indicative of the potential interaction with each other. These two aspects might partially be responsible for the decrement in serum UA content after ferulic acid ingestion. In conclusion, ferulic acid supplementation ameliorated lipid and glucose metabolic abnormalities, hepatic damage, and UA formation in MetS rats. There was a dose correlation between lipid deposition and UA synthesis-related indicators. These findings implied that ferulic acid could be applied as a promising dietary remedy for the management of MetS-associated HUA.

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Prevalence and Associations Between Metabolic Syndrome Components and Hyperuricemia by Race: Findings From US Population, 2011–2020

Kim,

Seo

et al. 2024

Arthritis Care & Research

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ObjectiveWe explored the trend in prevalence of hyperuricemia and metabolic syndrome in the US populations and investigated associations between components of metabolic syndrome and hyperuricemia by race.MethodsWe analyzed data from the four most recent NHANES cycles (2011 to March 2020), comprising 10,175 participants. Hyperuricemia is defined as serum urate > 7.0 mg/dL (men) or > 5.7 mg/dL (women), following the NHANES III guideline. Definition of metabolic syndrome follows National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP III) guideline. We estimated the prevalence of metabolic syndrome and hyperuricemia in each cycle and performed subgroup analyses with logistic regression to investigate the patterns of associated components of metabolic syndrome with hyperuricemia.ResultsIn the most recent cycle (2017‐March 2020), the prevalence of metabolic syndrome was 45.9% and that of hyperuricemia was 20.7%. Over the 2011‐2020 period, a significant rise in metabolic syndrome prevalence was observed among Hispanic and Asian populations, and the prevalence of hyperuricemia has increased significantly only in Hispanic. After adjustment for confounding factors, subjects with metabolic syndrome exhibited a higher hyperuricemia in women than in men. Elevated BP was the strongest factor with hyperuricemia. The association was the weakest in Asian population. Waist circumference was the only significant factor associated with hyperuricemia in Asian.ConclusionThe prevalence of metabolic syndrome has increasing pattern, but there was no specific decadal trend in prevalence of hyperuricemia. There is an ethnic‐specific association of metabolic syndrome and hyperuricemia, especially in Asian.image

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The bidirectional relationship between metabolic syndrome and hyperuricemia in China: A longitudinal study from CHARLS

Cited by 19 publications

References 28 publications

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Dietary Ferulic Acid Ameliorates Metabolism Syndrome-Associated Hyperuricemia in Rats via Regulating Uric Acid Synthesis, Glycolipid Metabolism, and Hepatic Injury

Prevalence and Associations Between Metabolic Syndrome Components and Hyperuricemia by Race: Findings From US Population, 2011–2020

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