The Beta-Blocking Effect of Practolol in Asthmatics

Bernecker, Christine; Roetscher, Ingrid

doi:10.1016/s0140-6736(70)91429-7

Cited by 33 publications

(7 citation statements)

References 6 publications

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“…Atenolol, though causing a significantly lesser increase in bronchial obstruction than oxprenolol, nevertheless does induce some increase. In this respect, in commmon with other ,-adrenoceptor antagonists claiming cardioselective activity [practolol (Bernecker & Roetscher, 1970;Waal-Manning & Simpson, 1971;Formgren, 1972), acebutolol (Skinner & Palmer, 1974) and metoprolol (Johnsson, Svedmyr & Thiringer, 1975)], atenolol does pose a potential hazard to asthmatics. Skinner & Palmer (1974) conclude that any ,-adrenoceptor blocking drug must be used with extreme caution in asthmatics, and Johnsson et al (1975) go as far as to recommend that the cardioselective P-adrenoceptor antagonist metoprolol should be given to asthmatics only if it is combined with afl2-receptor-stimulating drug.…”

Section: Discussionmentioning

confidence: 99%

“…(Bernecker & Roetscher, 1970;Waal-Manning & Simpson, 1971;Formgren, 1972), acebutolol (Skinner & Palmer, 1974) and metoprolol (Johnsson, Svedmyr & Thiringer, 1975)], atenolol does pose a potential hazard to asthmatics. Skinner & Palmer (1974) conclude that any ,-adrenoceptor blocking drug must be used with extreme caution in asthmatics, and Johnsson et al (1975) combined with afl2-receptor-stimulating drug.…”

Section: Airways Resistancementioning

confidence: 99%

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Comparison of atenolol and oxprenolol in patients with angina or hypertension and co‐existent chronic airways obstruction.

Perks¹,

Chatterjee²,

Croxson³

et al. 1978

Brit J Clinical Pharma

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1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with “fixed” airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with “labile” airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.

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Section: Discussionmentioning

confidence: 99%

Section: Airways Resistancementioning

confidence: 99%

Comparison of atenolol and oxprenolol in patients with angina or hypertension and co‐existent chronic airways obstruction.

Perks¹,

Chatterjee²,

Croxson³

et al. 1978

Brit J Clinical Pharma

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“…The risk is less with the cardioselective f-adrenoceptor blocking drug, practolol (Eraldin, I.C.I. Ltd) although a slight increase in airways resistance may occur with this drug in some asthmatic subjects (Macdonald & McNeill, 1968;Powles, Shinebourne & Hamer, 1969;Palmer, Legge, Hamilton & Diament, 1969;Bernecker & Roetscher, 1970). Acebutolol (Sectral, May & Baker Ltd) is a recently-developed ,B-adrenergic receptor blocking drug and will be available on prescription early in 1975.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of acebutolol (Sectral) and practolol (Eraldin) on airways obstruction in asthmatics.

Skinner¹,

Palmer²

1975

Brit J Clinical Pharma

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The effects of oral practolol (Eraldin, I.C.I. Ltd) (300 mg) and acebutolol (Sectral, May & Baker Ltd) (300 mg) were compared in a placebo‐controlled, crossover study in ten asthmatics. 2. Pulse rate, forced expiratory volume in one second (FEV1) and specific airways conductance were measured before and after a bronchodilator and the same procedure was repeated after taking acebutolol, practolol or placebo. 3. A mean increase in resting airways obstruction and reduction in bronchodilator response were evident with both drugs. The differences were statistically significant only after acebutolol for the logarithm of specific conductance. Mean plasma levels of the two drugs were similar. The response to both drugs was similar in the same patient and unrelated to severity of asthma. Mean reduction in resting pulse rate was statisitcally greater after acebutolol compared with placebo but not after practolol compared with placebo. 4. In any individual the beta‐adrenoceptor blocking response is unpredictable and any beta‐adrenoceptor blocking drug must be used with extreme caution in asthmatics.

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“…Some of these drugs, notably propranolol, frequently induce respiratory distress in asthmatic subjects, an effect thought to result from block of ,¢adrenoceptors in airways smooth muscle (McNeill, 1964;Richardson & Sterling, 1969 practolol . In clinical trials with asthmatic subjects practolol caused a much lower incidence of respiratory side effects than propranolol (MacDonald & McNeill, 1968;Bernecker & Roetscher, 1970 (Basil, Jordan, Loveless & Maxwell, 1973). The cardioselectivity of practolol and similar agents probably results from differences in the nature of the 3-adrenoceptors in cardiac and airways smooth muscle.…”

mentioning

confidence: 99%

The SELECTIVITY OF Β‐ADRENOCEPTOR ANTAGONISTS ON CARDIOVASCULAR AND BRONCHODILATOR RESPONSES TO ISOPRENALINE IN THE ANAESTHETIZED DOG

Daly¹,

Flook²,

Levy³

1975

British J Pharmacology

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1The actions of five 1-adrenoceptor antagonists, chosen because of reported differences in their selectivities, were compared using the positive chronotropic, vasodepressor and bronchodilator responses to isoprenaline in anaesthetized dogs. 2 Propranolol was a potent antagonist of the isoprenaline responses in all three systems. 3 Practolol and acebutolol (M & B 17,803) blocked the positive chronotropic responses to isoprenaline to a greater extent than the vasodepressor or bronchodilator responses. 4 Butoxamine and a-methyl dichloroisoprenaline showed the opposite selectivity, blocking the vasodepressor and bronchodilator responses to isoprenaline to a greater extent than positive chronotropic responses. However, both drugs were considerably less potent than the other antagonists studied and their selectivities were less clear-cut than those of practolol or acebutolol. 5 All the antagonists lowered the resting heart rate and to a lesser extent the diastolic blood pressure. The effects of propranolol, practolol and acebutolol on heart rate probably result from cardiac f-adrenoceptor blockade. With butoxamine and a-methyl dichloroisoprenaline, however, the effects on heart rate probably result from a direct cardiodepressant action. 6 The relevance of the results to the problem of the sub-classification of ,B-adrenoceptors is discussed.

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The Beta-Blocking Effect of Practolol in Asthmatics

Cited by 33 publications

References 6 publications

Comparison of atenolol and oxprenolol in patients with angina or hypertension and co‐existent chronic airways obstruction.

Comparison of atenolol and oxprenolol in patients with angina or hypertension and co‐existent chronic airways obstruction.

Comparison of the effects of acebutolol (Sectral) and practolol (Eraldin) on airways obstruction in asthmatics.

The SELECTIVITY OF Β‐ADRENOCEPTOR ANTAGONISTS ON CARDIOVASCULAR AND BRONCHODILATOR RESPONSES TO ISOPRENALINE IN THE ANAESTHETIZED DOG

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