The Benzyl Ester of Penicillin

Physiologic and Financial Economy in Nutrition

“…If, however, Jenkins and his colleagues are right, there would seem to be little excuse for continuing to place surgical gut in a solution of potential harm to surgical patients. 1 Satisfactory nutrition of a person or of a group of people depends ultimately on the money available for the purchase of food. Intimately involved in the solution of this essentially financial problem is the discovery of the factors that determine maximum economy in the physiologic utilization of essential nutrients.…”

THE USE OF DIAZO COMPOUNDS IN THE PREPARATION OF SOME BENZYLPENICILLIN ESTERS1

“…In a previous publication (1) interest was indicated in the preparation of benzylpenicillin esters and the results of preliminary tests with the benzyl ester were given. The program was initiated with the hope that some derivative of penicillin would be found which would be more suitable than the salts of benzylpenicillin for oral administration and which would have a depot action on injection.…”

“…Thus, d'Angelo and 1 Presented before the Division of Medicinal Chemistry of the American Chemical Society, Washington, D. C., August 31,1948. 1 Present address: University of California, Los Angeles, California. his co-workers (8,9) reported some diazoindoles, while Angelico reported diazopyrroles (10).…”

“…Antibiotic action. Serial dilution tests indicate that the neutral esters are considerably less active in vitro than the benzylpenicillin salt (1). Since the solubility of the neutral esters in aqueous media is very low, accurate comparisons are difficult to make.…”

“…pH 3.5) and tested by serial dilution in broth. 3 The results of in vivo mouse-protection tests (1) with Streptococcus hemolyticus are summarized in the table. 4 These results are from one hour post-infection subcutaneous administration of the ester in sesame oil.…”