The benzimidazole anthelmintic agents‐a review

McKellar, Quintin; Scott, E. W.

doi:10.1111/j.1365-2885.1990.tb00773.x

Cited by 344 publications

(244 citation statements)

References 117 publications

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“…febantel, a prodrug in vivo metabolized to the benzimidazoles fenbendazole and oxyfenbedazole (Mc Kellar and Scott, 1990); pyrantel; and praziquantel (PZQ), a broadspectrum anthelmintic against parasitic trematodes and cestodes (Andrews et al, 1983). …”

Section: Treatment In Animals and Animal Modelsmentioning

confidence: 99%

Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far

et al. 2016

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Treatment failures in patients suffering from giardiasis is not uncommon feature. The most frequent approach in these cases is to treat these patients with longer repeated courses and/or higher doses of the primary therapy, or using drugs from a different class to avoid potential cross-resistance. However, a higher rate of adverse events may limit this strategy. In this context, combination therapy (CT) is emerging as a valuable option against refractory giardiasis. In the attempt to evaluate the benefits of CT, a number of experimental studies, clinical series, and randomized clinical trials (RCTs), as well as several veterinary studies have been performed, with varying results. Here, we present a critical analysis of the available information regarding CT for the treatment of Giardia infection, as well as the authors' opinion with respect to its use. RCTs of combination therapy are limited and the optimal combinations and administration strategies need yet to be clarified. Analyses of the cost-effectiveness and RCTs of CTs for Giardia infection are required to assess the role of these drugs for the control of giardiasis, mainly in the case of treatment failures linked to suspected drug tolerance are the case. KeywordsGiardia To view all the submission files, including those not included in the PDF, click on the manuscript title on your EVISE Homepage, then click 'Download zip file'. HighlightsTreatment failures are not uncommon in giardiasis.Published studies have shown combination therapy in giardiasis to be safe and effective.Observations encourage the study of combinations of metronidazole with albendazole or quinacrine.Combination therapy could be a useful alternative in the case of treatment failures linked to suspected drug tolerance. Treatment failures in patients suffering from giardiasis are not uncommon feature. The most frequent approach in these cases is to treat these patients with longer repeated courses and/or higher doses of the primary therapy, or using drugs from a different class to avoid potential cross-resistance. However, a higher rate of adverse events may limit this strategy. In this context, combination therapy (CT) is emerging as a valuable option against refractory giardiasis. In the attempt to evaluate the benefits of CT, a number of experimental studies, clinical series, and randomized clinical trials (RCTs), as well as several veterinary studies have been performed, with varying results. Here, we present a critical analysis of the available information regarding CT for the treatment of Giardia infection, as well as the authors' opinion with respect to its use. RCTs of combination therapy are limited and the optimal combinations and administration strategies need yet to be clarified. Analyses of the cost-effectiveness and RCTs of CTs for Giardia infection are required to assess the role of these drugs for the control of giardiasis, mainly in the case of treatment failures linked to suspected drug tolerance are the case.

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Section: Treatment In Animals and Animal Modelsmentioning

confidence: 99%

Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far

et al. 2016

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“…These are commonly used anthelmintic drugs in many species (reviewed by McKellar and Scott, 1990). They include fenbendazole (FBZ), albendazole (ABZ) and oxfendazole (OFZ).…”

Section: Benzimidazolesmentioning

confidence: 99%

Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs: A mini-review

Ali

2004

Acta Veterinaria Hungarica

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This article reviews the literature dealing with the effects of composition and quality of diet and feeding time on the pharmacokinetics and efficacy of some anthelmintic drugs in ruminants. Studies have suggested that greater availability, and therefore improved anthelmintic activity, is possible through temporary feed restriction. It is also recommended that anthelmintic drugs should not be given to animals whilst they are maintained on large feed intakes, particularly of lush pasture that promotes rapid gastric transit, as this may reduce drug availability and anthelmintic efficacy. Generally, feeding animals low-quality fibrous diets reduces the passage rate of digesta and allows more time for absorption of several anthelmintic drugs and their metabolites from the gut. Some kinetic data of drugs given to animals on such diets may be slightly different, but this does not necessarily indicate alteration of the dosages of the anthelmintic drug. Nonetheless, due consideration should be given to anthelmintic dosages under various dietary regimes if optimum efficacy is to be achieved at all times.

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“…Due to the unique structural features, benzimidazole is reported to shown wide range of therapeutic activities [1][2][3]. Benzimidazole scaffold is a useful moiety for the development of molecules of pharmaceutical or biological interest [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Activity of 2-Azetidinone Derivatives of Benzimidazoles

Mehta¹,

Davadra

Pandya

et al. 2014

ILCPA

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The benzimidazole anthelmintic agents‐a review

Cited by 344 publications

References 117 publications

Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far

Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far

Effect of composition and quality of diet and feeding time on the kinetics and efficacy of some anthelmintic drugs: A mini-review

Synthesis, Characterization and Antimicrobial Activity of 2-Azetidinone Derivatives of Benzimidazoles

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