The benefits of <scp>COVID</scp>‐19 vaccination programmes for children may not outweigh the risks

Abecasis, Francisco

doi:10.1111/apa.16430

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…Nonetheless, the rate of myopericarditis in young males after mRNA COVID-19 vaccines was still higher than expected. Interestingly, another study sought to compare the incidence of myocarditis in COVID-19 vaccinees compared with SARS-CoV-2-infected individuals: findings revealed that the risk of myocarditis is more than seven times higher in individuals infected with the SARS-CoV-2 versus those who received the vaccine84; however, there is currently no evidence demonstrating that existing COVID-19 vaccines are protective against myocarditis associated with SARS-CoV-2 infection 85…”

Section: Discussionmentioning

confidence: 99%

Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis

et al. 2023

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ObjectiveTo summarise the available evidence on the risk of myocarditis and/or pericarditis following mRNA COVID-19 vaccination, compared with the risk among unvaccinated individuals in the absence of COVID-19 infection.DesignSystematic review and meta-analysis.Data sourcesElectronic databases (Medline, Embase, Web of Science and WHO Global Literature on Coronavirus Disease), preprint repositories (medRxiv and bioRxiv), reference lists and grey literature were searched from 1 December 2020 until 31 October 2022.Study selectionEpidemiological studies of individuals of any age who received at least one dose of an mRNA COVID-19 vaccine, reported a risk of myo/pericarditis and compared the risk of myo/pericarditis to individuals who did not receive any dose of an mRNA COVID-19 vaccine.Data extraction and synthesisTwo reviewers independently conducted screening and data extraction. The rate of myo/pericarditis among vaccinated and unvaccinated groups was recorded, and the rate ratios were calculated. Additionally, the total number of individuals, case ascertainment criteria, percentage of males and history of SARS-CoV-2 infection were extracted for each study. Meta-analysis was done using a random-effects model.ResultsSeven studies met the inclusion criteria, of which six were included in the quantitative synthesis. Our meta-analysis indicates that within 30-day follow-up period, vaccinated individuals were twice as likely to develop myo/pericarditis in the absence of SARS-CoV-2 infection compared to unvaccinated individuals, with a rate ratio of 2.05 (95% CI 1.49–2.82).ConclusionAlthough the absolute number of observed myo/pericarditis cases remains quite low, a higher risk was detected in those who received mRNA COVID-19 vaccinations compared with unvaccinated individuals in the absence of SARS-CoV-2 infection. Given the effectiveness of mRNA COVID-19 vaccines in preventing severe illnesses, hospitalisations and deaths, future research should focus on accurately determining the rates of myo/pericarditis linked to mRNA COVID-19 vaccines, understanding the biological mechanisms behind these rare cardiac events and identifying those most at risk.

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Section: Discussionmentioning

confidence: 99%

Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis

et al. 2023

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“…A review by Morello et al 1 concluded that the benefits of vaccinating children and adolescents against the virus that causes COVID‐19 appeared to outweigh the risks of post‐vaccination myopericarditis. In a different view, Abecasis states that the benefits of COVID‐19 vaccination programmes for children may not outweigh the risks 2 . Meanwhile, an editorial by Wilkinson et al lists five interrelated issues that should be considered when deciding whether to provide COVID‐19 vaccinations for children 3…”

Section: Ethics Of Giving Covid‐19 Vaccinations To Childrenmentioning

confidence: 99%

“…In a different view, Abecasis states that the benefits of COVID-19 vaccination programmes for children may not outweigh the risks. 2 Meanwhile, an editorial by Wilkinson et al lists five interrelated issues that should be considered when deciding whether to provide COVID-19 vaccinations for children. 3…”

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confidence: 99%

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Käll¹,

Lagercrantz²

2022

Acta Paediatrica

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“…In this issue of the journal, Abecasis argues against vaccination of otherwise healthy children against COVID‐19. 2 Others will likely disagree. Disagreement may be traced back to some of the specific issues noted above.…”

mentioning

confidence: 99%

“…Given these five factors, it is not surprising that different people and different countries will come to different conclusions about the appropriate vaccine policy for children. In this issue of the journal, Abecasis argues against vaccination of otherwise healthy children against COVID‐19 2 . Others will likely disagree.…”

mentioning

confidence: 99%

Ethical and scientific complexity in debates about COVID vaccination in children

2022

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The benefits of COVID‐19 vaccination programmes for children may not outweigh the risks

Cited by 7 publications

References 12 publications

Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis

Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis

Issue Highlights

Ethical and scientific complexity in debates about COVID vaccination in children

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