The benefits of a combination of surgery and chemotherapy in the management of &lt;i&gt;Buruli&lt;/i&gt; ulcer patients

Agbenorku, Pius; Agbenorku, Manolo; Gotah, E.; Saunderson, Paul; Lehman, Linda

doi:10.4314/just.v26i2.32983

Cited by 8 publications

(12 citation statements)

References 1 publication

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“…Observations were made by the team to take note of the environment and the lifestyle of the patients. Treatment at the various study sites was based on the current WHO guidelines [16, 17]; BU treatment was surgery (when necessary) combined with chemotherapy (a combination of Rifampicin and Streptomycin for 8 weeks as a first line) and physiotherapy.…”

Section: Methodsmentioning

confidence: 99%

Buruli Ulcer: Treatment Challenges at Three Centres in Ghana

Agbenorku

Donwi

Kuadzi

et al. 2012

Journal of Tropical Medicine

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Aims. This retrospective study was to identify some challenges in the treatment of Buruli ulcer (BU) and present a proposed treatment regime. Materials and Methods. Information from patients medical records, hospital database, and follow-up findings on BU treatment procedures from 1994 to 1998 and from 2004 to 2007 at three research sites in Ghana were reviewed to determine the treatment challenges encountered. Data needed were recorded and analyzed, and results presented using SPSS version 17.0. Results. A total of 489 BU patients information was selected for the study. A majority (56.90%, n = 278) of the patients were children (0–14 years), with a mean age of 12.8 years. Significant challenges in BU treatment in Ghana identified included sequelae (P = 0.041 ), delayed treatment (P = 0.012 ), and high treatment cost (P = 0.044 ). Duration of hospital stay was clearly correlated with the time spent at home prior to admission; spearman's rank correlation coefficient was 0.72 (95% CI 0.42–0.87). Conclusion. Delays in seeking treatment among BU patients were the main factor which resulted in most of the other factors contributing to the challenges in treatment. A combination of psychosocial and biomedical approach was proposed as holistic method to alleviate the challenges in BU treatment.

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Section: Methodsmentioning

confidence: 99%

Buruli Ulcer: Treatment Challenges at Three Centres in Ghana

Agbenorku

Donwi

Kuadzi

et al. 2012

Journal of Tropical Medicine

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“…No ulcer needed to be excised more than once as in other series. 15 In a three year review of management of MU disease at St Martin's Hospital at Agroyesum, Asiedu and Etuaful 16 saw a total of 102 patients; 36 in 1994, 34 in 1995, and 32 in 1996.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of Buruli ulcer disease: A four year experience from four endemic districts in Ghana

Adu

Ampadu²,

Acheampong³

2011

Ghana Medical Journal

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“…The “dual” mode of treatment (surgery + chemotherapy) reduced hospital admission period from 90 to 40 days, that's to 44.2%. This would directly reduce the cost of treatment for the BU patients [ 15 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…This treatment happens to be of great help for the surgery because it sterilizes wounds, limits the size of the excisions and reduces the number of relapses. It turned out that the surgery was not required for early stages [ 11 – 13 , 15 , 16 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Clinical efficacy of Rifampicin and Streptomycin in combination against Mycobacterium ulcerans infection: a systematic review

Vouking¹,

Tamo²,

Tadenfok³

2013

Pan Afr Med J

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Buruli ulcer (BU) is a cutaneous neglected tropical disease caused by Mycobacterium ulcerans. Synthesizing the evidence on their efficacy of antibiotic in the management of BU can help to better define their roles, identify weaknesses and inform clinicians on relevant measures than can be used to control BU. Our objectives is to assess the clinical efficacy of Rifampicin-Streptomycin given for 8 weeks of treatment of early M. ulcerans infection. We searched the following electronic databases from January 2005 to July 2012: Medline, EMBASE (Excerpta Medica Database), The Cochrane Library, Google Scholar, CINAHL (Cumulative Index to Nursing and Allied Health Literature), WHOLIS (World Health Organization Library Database), LILACS (Latin American and Caribbean Literature on Health Sciences) and contacted experts in the field. There were no restrictions to language or publication status. All study designs that could provide the information we sought for were eligible provided the studies were conducted in the third world. Critical appraisal of all identified citations was done independently by three authors to establish the possible relevance of the articles for inclusion in the review. Of the 115 studies, 09 papers met the inclusion criteria. The duration of treatment ranged from 8 to 48 weeks depending on the severity. Oral chemotherapy alone obtained a curative rate of 50%. The “dual” mode of treatment (surgery + chemotherapy) reduced hospital admission period from 90 to 39.8 days, that's to 44.2%. This treatment for early stages could therefore replace surgery and in severe cases, is an indispensable aid before surgery. These results confirmed that the daily administration of Rifampicin and Streptomycin is an effective treatment for M. ulcerans infection in an early stage. Subsequent systematic reviews should be conducted to determine if antibiotics could heal injuries without resorting to surgery and to compare different treatment durations.

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The benefits of a combination of surgery and chemotherapy in the management of <i>Buruli</i> ulcer patients

Cited by 8 publications

References 1 publication

Buruli Ulcer: Treatment Challenges at Three Centres in Ghana

Buruli Ulcer: Treatment Challenges at Three Centres in Ghana

Surgical management of Buruli ulcer disease: A four year experience from four endemic districts in Ghana

Clinical efficacy of Rifampicin and Streptomycin in combination against Mycobacterium ulcerans infection: a systematic review

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