The Benefit of Moderate Alcohol Use on Mood and Functional Ability in Later Life: Due to Beers or Frequent Cheers?

Scott, Roy W.; Wiener, Chelsea H; Paulson, Daniel

doi:10.1093/geront/gny129

Cited by 7 publications

(12 citation statements)

References 31 publications

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“…However, a dose-response meta-analysis of prospective studies found that light to moderate drinking is associated with a reduced risk of dementia ( Xu et al, 2017 ). Our results indicate that moderate drinking is favourable for cognition, which is consistent with a study that investigated drinking and functional ability using HRS data ( Scott et al, 2020 ). The risk of cognitive impairment did not decrease with the increased number of favourable lifestyles when never drinking was regarded as favourable, which further supports our opinion.…”

Section: Discussionsupporting

confidence: 92%

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Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study

Liu

Wang

Zou³

et al. 2022

Front. Mol. Neurosci.

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The relationship between body mass index (BMI) and cognitive impairment remains controversial, especially in older people. This study aims to confirm the association of phenotypic and genetic obesity with cognitive impairment and the benefits of adhering to a healthy lifestyle. This prospective study included 10,798 participants (aged ≥ 50 years) with normal cognitive function from the Health and Retirement Study in the United States. Participants were divided into low (lowest quintile), intermediate (quintiles 2–4), and high (highest quintile) groups according to their polygenic risk score (PRS) for BMI. The risk of cognitive impairment was estimated using Cox proportional hazard models. Higher PRS for BMI was associated with an increased risk, whereas phenotypic obesity was related to a decreased risk of cognitive impairment. Never smoking, moderate drinking, and active physical activity were considered favourable and associated with a lower risk of cognitive impairment compared with current smoking, never drinking, and inactive, respectively. A favourable lifestyle was associated with a low risk of cognitive impairment, even in subjects with low BMI and high PRS for BMI. This study suggest that regardless of obesity status, including phenotypic and genetic, adhering to a favourable lifestyle is beneficial to cognitive function.

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Section: Discussionsupporting

confidence: 92%

“…Smoking status was divided into never, former, and current smoking. Drinking status was classified as never, former, current moderate, and excessive drinking according to established standards ( Scott et al, 2020 ). Regular active physical activity was defined as at least two times a week for light, moderate, or vigorous physical activity.…”

Section: Methodsmentioning

confidence: 99%

Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study

Liu

Wang

Zou³

et al. 2022

Front. Mol. Neurosci.

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“…Besides, alcohol consumption might be related to psychosocial and physical status among breast cancer patients, thus explaining the improved overall and breast cancer-specific survival. Although excessive alcohol intake may be associated with poor health status [37, 38], light to moderate drinkers may have better physical and mental health and sociability than non-drinkers [37–41]. According to our previous population-based cohort study investigating the association of personality with breast cancer risk and survival, none of the personality subscales was associated with breast cancer risk, whereas subsequent follow-up of incident cases of breast cancer demonstrated that a higher score for extraversion, representing sociability and liveliness, tended to be associated with a lower risk of all-cause-death [42].…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study

et al. 2019

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BackgroundIt is unclear whether alcohol consumption may impact survival after breast cancer diagnosis. To clarify the association between pretreatment alcohol consumption and survival in breast cancer patients, a prospective patient cohort study was conducted.MethodsThe cohort comprised 1,420 breast cancer patients diagnosed during 1997–2013 at a single institute in Japan. Alcohol drinking and other lifestyle factors were assessed by questionnaire survey at the initial admission. The patients were followed until December 31, 2016. The crude associations of pretreatment alcohol intake with survival were evaluated by Kaplan-Meier analysis. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) controlled by confounders.ResultsDuring a median follow-up period of 8.6 years, 261 all-cause and 193 breast cancer-specific deaths were documented. Survival curves showed that ever-drinkers tended to have better survival than never-drinkers (breast cancer-specific survival, log-rank p = 0.0381). Better survival was also observed for light drinkers with an intake of <5.0 g per day. In the Cox model, ever-drinking was associated with a decreased risk of all-cause (HR: 0.75; 95% CI: 0.54–1.05) and breast cancer-specific death (HR: 0.68; 95% CI: 0.46–0.99). Light drinkers had a lower risk of breast cancer-specific death (frequency of drinking, HR = 0.57 for occasional or 1–2 times per week and 0.72 for 3–7 times per week; amount of alcohol consumed per day, HR = 0.57 for <5.0 g and 0.68 for ≥5.0 g compared with never-drinking). In terms of hormone receptor status, a significantly decreased risk of death associated with ever-drinking was observed among women with receptor-negative cancer (ER-/PR-, HR = 0.41; 95% CI: 0.20–0.84 for breast cancer-specific death).ConclusionsPretreatment, i.e., pre-diagnosis alcohol consumption is unlikely to have an adverse effect on survival after breast cancer diagnosis. Light alcohol consumption may have a beneficial effect on patient survival.

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“…Alcohol consumption is a major cause of disease burden worldwide, mostly from liver disease, cancer, and injuries . However, moderate and regular alcohol consumption was consistently linked to better physical performance and lower risk of functional limitations in older adults . For example, one cross‐sectional study in men aged 65 years and older in the United States showed that compared with abstainers, moderate alcohol intake was associated with lower odds of reporting a functional limitation .…”

mentioning

confidence: 99%

“…6,7 However, moderate and regular alcohol consumption was consistently linked to better physical performance and lower risk of functional limitations in older adults. [8][9][10][11][12][13] For example, one cross-sectional study in men aged 65 years and older in the United States showed that compared with abstainers, moderate alcohol intake was associated with lower odds of reporting a functional limitation. 11 Another 20-year cohort study in older women in the United States reported that moderate vs never-drinkers had better walking speed and less difficulty with instrumental activities of daily living (IADLs).…”

mentioning

confidence: 99%

Alcohol Consumption and Functional Limitations in Older Men: Does Muscle Strength Mediate Them?

Wang

Sun

et al. 2019

J American Geriatrics Society

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OBJECTIVES To evaluate the dose‐response relationships between alcohol consumption and functional limitations in older European men, and explore the role of muscle strength as a mediator of these relationships. DESIGN Cross‐sectional study of older men participating in the Survey of Health, Aging and Retirement in Europe (SHARE). SETTING Urban and rural households in 17 European countries and Israel. PARTICIPANTS A total of 17 870 men aged 65 years and older from the SHARE (Wave 6, 2015) were included in this study. MEASUREMENTS Outcome variables were functional limitations: mobility limitation, arm function limitation, and fine motor limitation. Main exposure variable was alcohol consumption. Mediating factor was grip strength. Basic demographics, life habits, and health status were considered as potential confounders. Dose‐response analyses with restricted cubic splines and the Karlson/Holm/Breen method were conducted. RESULTS A total of 17 870 participants were included in this study. Dose‐response analyses revealed that moderate alcohol consumption was related to the lower odds of reporting mobility limitation (≤35 units/wk) and arm function limitation (≤41 units/wk), with a minimum odds ratio (OR) occurring at 10 units/week drinks for mobility limitation (OR = .71; 95% confidence interval [CI] = .62‐.81) and arm function limitation (OR = .66; 95% CI = .59‐.75). The odds of reporting the fine motor limitation monotonically increased with alcohol consumption when alcohol consumption was beyond 15 units/week. No significant mediating effect of grip strength on the relationships between alcohol consumption and mobility limitation and arm function limitation was found. CONCLUSION Moderate alcohol consumption has a protective role in mobility and arm function limitation in older European men. Grip strength is not the main mediator of these associations, suggesting that the protective effect is independent of muscle strength. Alcohol consumption is associated with higher odds of reporting fine motor limitation in older European men. J Am Geriatr Soc 67:2331–2337, 2019

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The Benefit of Moderate Alcohol Use on Mood and Functional Ability in Later Life: Due to Beers or Frequent Cheers?

Cited by 7 publications

References 31 publications

Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study

Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study

Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study

Alcohol Consumption and Functional Limitations in Older Men: Does Muscle Strength Mediate Them?

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