2021
DOI: 10.1016/j.accpm.2020.06.017
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The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial

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Cited by 16 publications
(12 citation statements)
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“…Additionally, ketamine remarkably limits the diapedesis of the neutrophils to the site of in ammation 42 and resolves the in ammatory reaction by promoting immune cell apoptosis and further reducing proin ammatory cytokine release 43 . Moreover, clinical evidence has proved that the severe state of critically ill patients and experimental septic shock could be improved with ketamine intervention 44 . Overall, SIRS is the terminal disease state.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, ketamine remarkably limits the diapedesis of the neutrophils to the site of in ammation 42 and resolves the in ammatory reaction by promoting immune cell apoptosis and further reducing proin ammatory cytokine release 43 . Moreover, clinical evidence has proved that the severe state of critically ill patients and experimental septic shock could be improved with ketamine intervention 44 . Overall, SIRS is the terminal disease state.…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, the cardiac output was assessed noninvasively using electric cardiometry. Electric cardiometry-derived absolute cardiac output values were reported as not interchangeable with the thermodilution method [ 27 ]; however, electric cardiometry had acceptable trending ability [ 28 ]; thus, it was used to follow-up the changes in the cardiac output in various populations [ 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was reported that intravenous infusion of lidocaine could blunt the hemodynamic response to endotracheal intubation during induction of anaesthesia [21]. Hypotension is a common complication after induction of general anaesthesia and lidocaine-ketamine combination could significant decrease incidence of hypotension compared to ketamine when used for endotracheal intubation in patients with circulatory failure [22].Our study found that the fluctuation of MAP and HR after gastroscopy implanted in group L were lower than those in group S. In addition, IV lidocaine can reduce the incidence of cough in patients undergoing gastroscopy. A meta-analysis has shown that intravenous lidocaine may be a best chose to decrease emergence coughing during anesthesia recovery and endotracheal tube pulled out in adult elective surgery [23].Furthermore, IV lidocaine may exert central anti-nociceptive effects by action on muscarinic and nicotinic receptors, which reinforce the inhibitory descending pain pathway in rats experiment [24].These findings in our study showed that lidocaine could stabilize the hemodynamic fluctuation after gastroscopy implanted, and reduce the incidence of intraoperative cough.…”
Section: Discussionmentioning
confidence: 99%