The beneficial mechanism of chitosan and chitooligosaccharides in the intestine on different health status

Chen, Yanli; Ling, Zhenmin; Wang, Xing; Zong, Simin; Yang, Jinfeng; Zhang, Qing; Zhang, Jing; Li, Xiangkai

doi:10.1016/j.jff.2022.105232

Cited by 9 publications

(2 citation statements)

References 41 publications

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“…Other SCFA-reducing bacteria, such as Coprobacillus and Butyricimonas , were both more abundant in the M9 group as compared to the fructose group, which suggests their roles in BP regulation. Previous studies found that Coprobacillus can affect human health in various ways, such as by inhibiting fat absorption ( 30 ),and reducing immune system reactivation and inflammation ( 31 ). These observations, along with our findings, underline the fact that SCFA production is not the only relevant function of these bacteria, and other metabolic capacities of the gut microbiota may also contribute to BP regulation.…”

Section: Discussionmentioning

confidence: 99%

Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products

Zhang,

Zheng,

et al. 2023

mSystems

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High-fructose intake is one of the high-risk factors for hypertension. Several probiotics have been reported to reduce high blood pressure (BP) via modulating gut microbiota, but the mechanism of the antihypertensive effect of probiotics is insufficiently understood. Herein, we investigated the antihypertensive effect of Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 based on the integrative analysis of gut metagenome and serum metabolome in high-fructose-treated mice. After 16-week intervention, M8 and M9 significantly reduced the median blood pressure by 16.92% and 15.39% in SBP, and 18.56% and 20.62% in DBP, respectively. Metagenomic analysis revealed that the increased Lawsonia and Pyrolobus , and reduced Alistipes and Alloprevotella levels were tightly correlated with lowered BP. Functionally, the decreased pathways of “base excision repair” (BER) and “D-glutamine and D-glutamate metabolism” were associated with BP reduction. Metabolomics data analysis further revealed that the probiotic interventions regulated vascular smooth muscle contraction, serotonergic synapse, cholinergic synapse, and lipid and vitamin metabolism in BP control. Additionally, association analyses indicated a strong negative correlation between Alistipes and “steroid hormone biosynthesis,” suggesting that Alistipes could affect blood pressure by changing steroid hormone levels. In conclusion, our findings indicate that the probiotic efficacies in alleviating hypertension are linked to specific gut microbes and metabolic pathways, which provide a potential mechanistic understanding of probiotics modulated blood pressure, paving the way for future assessment of the therapeutic potential of probiotics in hypertension management. Elevated blood pressure affects 40% of the adult population, which accounts for high cardiovascular disease risk and further high mortality yearly. The global understanding of the gut microbiome for hypertension may provide important insights into the prevention. Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 originated from human breast milk, were able to decrease blood pressure, and modified metabolites in a high fructose-induced elevated blood pressure mouse model. Moreover, we found there was a close relationship between unexplored gut microbes and elevated blood pressure. Also, subsequently, the cross-link was explored among gut microbes, metabolites, and some metabolic pathways in gut microbial environment through introducing novel prediction methodology and bioinformatic analysis. It allowed us to hypothesize that probiotics can prevent elevated blood pressure via gut microbiota and related metabolism.Thus, utilization of dietary strategies (such as probiotics) to maintain the blood pressure level is of crucial importance.

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Section: Discussionmentioning

confidence: 99%

Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products

Zhang,

Zheng,

et al. 2023

mSystems

View full text Add to dashboard Cite

show abstract

“…Chitosan oligosaccharide ( COS ) is an oligosaccharide from chitin or chitosan, which is an environmentally friendly feed additive with beneficial effects on animal nutrition ( Chen et al, 2022b ; Uyanga et al, 2023 ). Former studies illustrated that dietary COS supplementation had beneficial effects on growth performance, intestinal function, immune response, antioxidant capacity and lipid metabolism in broilers ( Lan et al, 2019 , 2020b , 2021 , 2023 ; Chang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Chitosan oligosaccharide improves intestinal function by promoting intestinal development, alleviating intestinal inflammatory response, and enhancing antioxidant capacity in broilers aged d 1 to 14

Lan,

Wu,

Wang

et al. 2024

Poultry Science

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Multiple omics integration analysis reveals the regulatory effect of chitosan oligosaccharide on testicular development

Dong,

Yan,

Chen

et al. 2024

Ecotoxicology and Environmental Safety

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The beneficial mechanism of chitosan and chitooligosaccharides in the intestine on different health status

Cited by 9 publications

References 41 publications

Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products

Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products

Chitosan oligosaccharide improves intestinal function by promoting intestinal development, alleviating intestinal inflammatory response, and enhancing antioxidant capacity in broilers aged d 1 to 14

Multiple omics integration analysis reveals the regulatory effect of chitosan oligosaccharide on testicular development

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