The Beneficial Health Effects of Fucoxanthin

Miyashita, Kazuo; Hosokawa, Masashi

doi:10.1002/9781118930458.ch10

Cited by 4 publications

(3 citation statements)

References 115 publications

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“…In addition, it has been demonstrated that Fx, unlike other carotenoids, quenches free radicals also in anoxic conditions [53]. The most naturally occurring trans isomer showed stronger activity than the cis isomer, although pure Fx has been shown to be susceptible to oxidation, whereas this event does not occur when the bioactive compound is within a plant-complex [54]. This could be the reason why, although Fx represents the most abundant compound in PTE, in our study the plant-complex always shows a biological activity, be it antioxidant, anti-inflammatory, and skin photoprotective, greater than the pure molecule tested at the same concentrations within PTE.…”

Section: Discussionmentioning

confidence: 99%

Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model

Smeriglio,

Lionti,

Ingegneri

et al. 2023

Molecules

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The nutritional and health properties of algae make them perfect functional ingredients for nutraceutical and cosmeceutical applications. In this study, the Phaeodactylum tricornutum Bohlin (Phaeodactylaceae), a pleiomorphic diatom commonly found in marine ecosystems, was investigated. The in vitro culture conditions used favoured the fusiform morphotype, characterized by a high accumulation of neutral lipids, as detected by fluorescence microscopy after BODIPY staining. These data were confirmed by HPLC-DAD-APCI-MS/MS analyses carried out on the ethanolic extract (PTE), which showed a high content of xanthophylls (98.99%), and in particular of fucoxanthin (Fx, 6.67 g/100 g PTE). The antioxidant activity (ORAC, FRAP, TEAC and β-carotene bleaching) and photostability of PTE and Fx against UVA and UVB rays were firstly evaluated by in vitro cell-free assays. After this, phototoxicity and photoprotective studies were carried out on in vitro reconstructed human epidermidis models. Results demonstrated that PTE (0.1% Fx) and 0.1% Fx, both photostable, significantly (p < 0.05) reduce oxidative and inflammatory stress markers (ROS, NO and IL-1α), as well as cytotoxicity and sunburn cells induced by UVA and UVB doses simulating the solar radiation, with an excellent safety profile. However, PTE proved to be more effective than Fx, suggesting its effective and safe use in broad-spectrum sunscreens.

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Section: Discussionmentioning

confidence: 99%

Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model

Smeriglio,

Lionti,

Ingegneri

et al. 2023

Molecules

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“…Fx, the main pigment present in diatoms thylakoid in the light harvesting complexes, has antioxidant properties and can act under anoxic condition, what is unique among carotenoids [21]. Fx shows anti-cancer, anti-obesity and antidiabetic activities [22,23,24,25,26] and can inhibit inflammatory response [27]. Ddx and Dtx protect the photosynthetic apparatus against oxidative stress generated by high light [28].…”

Section: The Fourth Face -Treasury Bioactive Compounds In Diatomsmentioning

confidence: 99%

The Five Different Faces of the Diatoms

Bojko¹,

Latowski²

2019

Proceedings of the 5th World Congress on New Technologies

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Diatoms are one of the most important groups of photosynthetic microorganisms ubiquitous in all aquatic ecosystems. These inconspicuous organisms have achieved spectacular ecological success and furthermore, are used as model organisms in scientific research in the field of biochemistry and genetics. Their ecological success is provided by their ability to tolerance and fast acclimation to rapid changing environmental conditions. Ecological significance and the ease of culture facilitate investigation and attempts of explanation the mechanisms of processes occurring in these organisms on the physiological, biochemical and genetic level. This review describes a number of our investigation strategies and techniques to understand the phenomenon of these organisms. We focused on five important aspects of diatoms biology, presented here as the five different faces of these algae. Acclimation mechanisms to environmental factors (temperature, light, heavy metals, age of the culture), on physiological and biochemical level at short and long time exposition of diatoms, are presented as the first diatoms face. The second face presents diatoms as organisms useful for phytoremediation. The results of the molecular analyses of the selected enzymes involved in photoprotective mechanisms of diatoms is the third face of these algae. The significance of diatoms as a treasury of bioactive compounds (xanthophylls and long chain polyunsaturated fatty acids) important in human diet, is displayed as the fourth face. Finally, as the only one which has not been investigated in our laboratory, we describe the fifth face of diatomsthe rich source of biofuels. In our research we used two model diatoms species: Phaeodactylum tricornutum and Thalassiosira pseudonana.

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“…Moreover, Fx can act as an antioxidant under anoxic conditions, which is very rare among carotenoids (Nomura et al, 1997). The beneficial health properties of Fx include anti-cancer (induction of apoptosis and cell cycle arrest in cancer cells), anti-obesity (induction of uncoupling protein-1 in white adipose tissue), anti-photoageing and antidiabetic activities (summarized by D' Orazio et al, 2012;Mikami & Hosokawa, 2013;Kumar et al, 2013;Moghadamtousi et al, 2014;Miyashita & Hosokawa, 2015). Furthermore, it is capable of inhibiting the inflammatory response (Choi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Column chromatography as a useful step in purification of diatom pigments

et al. 2016

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Fucoxanthin, diadinoxanthin and diatoxanthin are carotenoids found in brown algae and most other heterokonts. These pigments are involved in photosynthetic and photoprotective reactions, and they have many potential health benefits. They can be extracted from diatom Phaeodactylum tricornutum by sonication, extraction with chloroform : methanol and preparative thin layer chromatography. We assessed the utility of an additional column chromatography step in purification of these pigments. This novel addition to the isolation protocol increased the purity of fucoxanthin and allowed for concentration of diadinoxanthin and diatoxanthin before HPLC separation. The enhanced protocol is useful for obtaining high purity pigments for biochemical studies.

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The Beneficial Health Effects of Fucoxanthin

Cited by 4 publications

References 115 publications

Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model

Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model

The Five Different Faces of the Diatoms

Column chromatography as a useful step in purification of diatom pigments

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