The Beneficial Effects of Soybean Proteins and Peptides on Chronic Diseases

Abstract

With lifestyle changes, chronic diseases have become a public health problem worldwide, causing a huge burden on the global economy. Risk factors associated with chronic diseases mainly include abdominal obesity, insulin resistance, hypertension, dyslipidemia, elevated triglycerides, cancer, and other characteristics. Plant-sourced proteins have received more and more attention in the treatment and prevention of chronic diseases in recent years. Soybean is a low-cost, high-quality protein resource that contains 40% protein. Soybean peptides have been widely studied in the regulation of chronic diseases. In this review, the structure, function, absorption, and metabolism of soybean peptides are introduced briefly. The regulatory effects of soybean peptides on a few main chronic diseases were also reviewed, including obesity, diabetes mellitus, cardiovascular diseases (CVD), and cancer. We also addressed the shortcomings of functional research on soybean proteins and peptides in chronic diseases and the possible directions in the future.

Elevating the significance of legume intake: A novel strategy to counter aging‐related mitochondrial dysfunction and physical decline

“…The protein extraction from peas, chickpeas, and other beans has attracted attention due to its good amino acid balance and high protein bioavailability (Zhang et al, 2023). Among legume-based proteins, several proteins (enzyme inhibitors, lectins, and storage globulins) and peptides (lunasin and hydrophobic peptides) extracted from legumes have shown significant health benefits such as anticancer, antiaging, hypoglycemic, antioxidant, antibacterial, and immune-stimulating properties ( Carbonaro & Nucara, 2022;Garcés-Rimón et al, 2022;Hu et al, 2023).…”

Condensation of Soy Protein Peptides Contributes to Sequester Bile Acids and Mitigate LPS-Induced Inflammation

“…They have been shown to exhibit potent bioactivities, such as antiinflammatory function. 29 In a previous study, we observed that ER peptides tended to bind to lipopolysaccharide (LPS) in a physiologically relevant ion environment. 27 This binding capability may enable ER peptides to capture LPS in the GIT and ultimately ameliorate LPS-induced host inflammatory conditions.…”

“…Soybean peptides are derived through the digestion or hydrolysis of soybean proteins using various proteases. They have been shown to exhibit potent bioactivities, such as anti-inflammatory function . In a previous study, we observed that ER peptides tended to bind to lipopolysaccharide (LPS) in a physiologically relevant ion environment .…”

A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

“…As a traditional legume crop, soybean (Glycine max) has been cultivated in China for nearly 5000 years, and China is the world's largest soybean processing and consumption country (X. Guo et al, 2021;S. Hu et al, 2023).…”