The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis

Dias, Paula Cristina Silveira; Sena-Evangelista, Karine Cavalcanti Maurício; Paiva, Maria Sanali Moura de Oliveira; Ferreira, Diana Quitéria Cabral; Ururahy, Marcela Abbott Galvão; Rezende, Adriana Augusto de; Abdalla, Dulcinéia Saes Parra; Pedrosa, Lúcia Fátima Campos

doi:10.1016/j.jtemb.2014.01.003

Cited by 22 publications

(8 citation statements)

References 34 publications

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“…The fact that we found no correlations between erythrocyte zinc concentration and cardiometabolic risk factors such as hs-CRP may be explained by the lack of responsiveness of erythrocyte zinc biomarker to variations in zinc intake [ 21 ]. However, the high erythrocyte zinc concentration observed in 64% of patients with MS supports a previous study by Dias et al [ 47 ]. The authors of that study observed that patients with altered inflammatory profiles, similar to our patients, had mean erythrocyte zinc concentration above the reference values.…”

Section: Discussionsupporting

confidence: 89%

Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

et al. 2017

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Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0.001). Regression models indicated no significant differences in plasma zinc concentration (all p > 0.05) between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p < 0.001) independent from co-variable adjustments. Twenty-four hour urinary zinc excretion was significantly higher in the MS group (p = 0.008), and adjustments for age and sex explained 21% of the difference (R2 = 0.21, p < 0.001). There were significant associations between zincuria and fasting blood glucose concentration (r = 0.479), waist circumference (r = 0.253), triglyceride concentration (r = 0.360), glycated hemoglobin concentration (r = 0.250), homeostatic model assessment—insulin resistance (r = 0.223), and high-sensitivity C-reactive protein concentration (r = 0.427) (all p < 0.05) in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria.

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Section: Discussionsupporting

confidence: 89%

Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

et al. 2017

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“…Decreased circulating levels of MDA among diabetic patients have also reported following supplementation with 30 mg/day zinc for 6 months . However, no significant effect in hs‐CRP concentrations was seen after intake of 10 mg rosuvastatin for 4 months with or without 30 mg/day zinc in subjects with atherosclerosis . Moreover, 233 mg zinc gluconate (containing 30 mg zinc) administration among GDM women for 6 weeks did not influence MDA levels .…”

Section: Discussionmentioning

confidence: 94%

Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Momen‐Heravi

Barahimi

Razzaghi

et al. 2017

Wound Repair Regeneration

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This study was performed to determine the effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer. The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 40-85 years old) with grade 3 diabetic foot ulcer. Participants were randomly divided into two groups (30 participants in each group) to take either 220 mg zinc sulfate supplements containing 50 mg elemental zinc or placebo daily for 12 weeks. After the 12-week intervention, compared with the placebo, zinc supplementation was associated with significant reductions in ulcer length (-1.5 ± 0.7 vs. -0.9 ± 1.2 cm, p = 0.02) and width (-1.4 ± 0.8 vs. -0.8 ± 1.0 cm, p = 0.02). In addition, changes in fasting plasma glucose (-40.5 ± 71.0 vs. -3.9 ± 48.5 mg/dl, p = 0.02), serum insulin concentration (-8.0 ± 15.4 vs. +1.1 ± 10.3 µIU/ml, p = 0.009), homeostasis model of assessment-estimated insulin resistance (-3.9 ± 7.1 vs. +0.8 ± 5.9, p = 0.007), the quantitative insulin sensitivity check index (+0.01 ± 0.03 vs. -0.002 ± 0.02, p = 0.04) and HbA1c (-0.5 ± 0.8 vs. -0.1 ± 0.5%, p = 0.01) in the supplemented group were significantly different from the changes in these indicators in the placebo group. Additionally, significant increases in serum HDL-cholesterol (+4.1 ± 4.3 vs. +1.1 ± 5.1 mg/dl, p = 0.01), plasma total antioxidant capacity (+91.7 ± 213.9 vs. -111.9 ± 188.7 mmol/L, p < 0.01) and total glutathione (+68.1 ± 140.8 vs. -35.0 ± 136.1 µmol/L, p = 0.006), and significant decreases in high sensitivity C-reactive protein (-20.4 ± 24.6 vs. -6.8 ± 21.3 µg/ml, p = 0.02) and plasma malondialdehyde concentrations (-0.6 ± 0.9 vs. -0.2 ± 0.7 µmol/L, p = 0.03) were seen following supplementation with zinc compared with the placebo. Zinc supplementation for 12 weeks among diabetic foot ulcer patients had beneficial effects on parameters of ulcer size and metabolic profiles.

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“…However, no significant effect of Zn supplementation was observed on inflammatory cytokines and biomarkers of oxidative stress (29). Likewise, another study by Dias et al in patients with atherosclerosis demonstrated that Zn supplements (30 mg/day) and rosuvastatin had no impact on hs-CRP concentration after 4 months (41). The discrepancy of the results in these RCTs may be due to several confounding variables, which include: study population size, Zn intervention dose, duration of supplementation and baseline serum CRP level.…”

Section: Discussionmentioning

confidence: 98%

Zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials

et al. 2021

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The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis

Cited by 22 publications

References 34 publications

Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

Expression of Concern: The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials

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