The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence

Zagaar, Munder; Alhaider, Ibrahim A.; Dao, An T.; Levine, Amber T.; Alkarawi, Ahmed; Alzubaidy, Mariam; Alkadhi, Karim A.

doi:10.1016/j.nbd.2011.12.039

Cited by 102 publications

(104 citation statements)

References 69 publications

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“…Studies in the case explicitly confirm the proposition that stress induced by sleep deprivation impairs cognitive factors such as memory and learning (21,22).…”

Section: Introductionmentioning

confidence: 72%

“…It was reported that this method allowed animals to have general sleep but interfered with REM sleep. When muscle tone was lost during REM sleep, the rats fell into the water and the water caused the animals awaken (21)(22)(23). After implementing the sleep deprivation protocol, the rats were randomly divided into an exercise and control group (n = 8 rats for each group).…”

Section: Sleep Deprivation Protocolmentioning

confidence: 99%

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The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Darkhah

Zarghami

Bushehri

et al. 2016

Jentashapir J Health Res

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“…Studies in the case explicitly confirm the proposition that stress induced by sleep deprivation impairs cognitive factors such as memory and learning (21,22).…”

Section: Introductionmentioning

confidence: 72%

Section: Sleep Deprivation Protocolmentioning

confidence: 99%

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Darkhah

Zarghami

Bushehri

et al. 2016

Jentashapir J Health Res

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“…The absence of morphological changes in the cell bodies of hippocampal neurons, including accumulation or aggregation of nuclei and shrinking or swelling of the cell bodies, indicates that the axonal degeneration we observed in vitamin E-deficient and normal old mice was an early event that occurred before the induction of cell death. It is well known that the hippocampal CA1 region plays a pivotal role in cognitive function (25,26), and it is possible that axonal degeneration of the hippocampal CA1 region of vitamin E-deficient and old mice is one of the mechanisms underlying cognitive dysfunction in these models.…”

Section: Axonal Degeneration In the Hippocampal Ca1 Region Of Vitaminmentioning

confidence: 99%

Vitamin E Deficiency Induces Axonal Degeneration in Mouse Hippocampal Neurons

Fukui

Kawakami

Honjo

et al. 2012

J Nutr Sci Vitaminol

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SummarySeveral lines of evidence demonstrate the relationship between vitamin E deficiency and cognitive dysfunction in rodent models, but little is known about the underlying mechanisms. In this study, we found axonal injury in the hippocampal CA1 region of vitamin E-deficient and normal old mice using immunohistochemical assay. The number of cells in the hippocampal CA1 region of vitamin E-deficient mice and normal old mice was significantly lower than in normal young mice. It is well known that collapsin response mediator protein (CRMP)-2 plays a crucial role in the maintenance of axonal conditions. The expressions of CRMP-2 in the cerebral cortex and hippocampus of vitamin E-deficient mice were significantly lower than both the regions of normal ones. In normal old mice, the expression of CRMP-2 in the cerebral cortex was significantly lower than in the normal ones. In addition, the appearance of microtubule-associated protein (MAP)-light chain 3 (LC3), a major index of autophagy, was higher in the cerebral cortex and hippocampus of vitamin E-deficient mice than in normal young and old mice. These results indicate that axonal degeneration is induced in living tissues, but not cultured cells, and that changes in CRMP-2 and MAP-LC3 may underlie vitamin E-deficiency-related axonal degeneration.

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“…Therefore, it is plausible that the anxiolytic-like effect of SD, which might be due to the method we used for SD induction, made the animals exercise while being sleep deprived. A recent report has shown that the regular treadmill exercise regimen in rats prevents the SD-associated decline in BDNF expression in CA1 (hippocampus) (43). Moreover, it has been proposed that the antioxidant and anxiolytic-like effect of exercise may ameliorate the stress-induced damages to the brain (44).…”

Section: Discussionmentioning

confidence: 99%

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

et al. 2014

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Background: Sleep deprivation (SD) is emerging as a hot topic due to its health concerns. There are compelling reasons for a tremendous interest in neuroscience of sleep in recent years. Objectives: We aimed to evaluate how total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR) might affect memory, anxiety-related behaviors, and the serum level of neurochemical markers such as brain-derived neurotrophic factor (BDNF) and corticosterone in a rat model. Materials and Methods:The disk-over-water (DOW) apparatus was employed to induce TSD and CPSR in male Wistar rats. The six study arms were as follows: cage control, 48 hours; cage control, seven days; DOW control, 48 hours; DOW control, seven days, TSD, and CPSR. Elevated plus-maze (EPM) was used to measure parameters (percentage of OAT, percentage of OAE, and locomotor activity) corresponding to anxiety and aversive memory. To measure serum BDNF and corticosterone levels using the ELISA method, blood samples were drawn from all rats on the fourth day at 5 P.M. Results: Our results demonstrated that TSD (P < 0.001) and CPSR (P < 0.001) induce memory impairment while exert anxiolytic-like effects in comparison with controls. Data showed that CPSR causes more memory impairment and anxiolytic-like effect in comparison to TSD (P < 0.001).These interventions however, did not alter the locomotor activity. Serum corticosterone level raised dramatically in CPSR rats in comparison to TSD and controls. Although the difference in serum BDNF level between TSD and CPSR arms was insignificant, it was markedly decreased in comparison to corresponding controls (P < 0.001). Conclusions: Our findings suggest the more pronounced effect of CPSR rather than TSD in impairing aversive memory and reducing anxiety. Decreased BDNF and peaked corticosterone level in TSD and CPSR suggest the probable inflammatory processes involved in possible insults to the brain caused by SD.

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The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence

Cited by 102 publications

References 69 publications

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Vitamin E Deficiency Induces Axonal Degeneration in Mouse Hippocampal Neurons

Aversive Memory, Anxiety-Related Behaviors, and Serum Neurochemical Levels in a Rat Model of Labored Sleep Loss

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