The beneficial effects of purple yam (Dioscorea alataL.) resistant starch on hyperlipidemia in high-fat-fed hamsters

Abstract

In this study, we investigated the interventional effect of resistant starch (RS) obtained from purple yam (Dioscorea alata L.) on regulating lipid metabolism and gut microbiota in hyperlipidemic hamsters.

Effect of resistant starch supplementation on blood lipids in metabolic disorder adults: A meta analysis of randomized controlled trials

“…RS replaced for digestible starch in the diet can lower serum cholesterol concentrations in normal or hypercholesterolemic conditions in animals. [4][5][6][7][8][9][10] However, in humans, these findings are not yet fully supported. For example, the cholesterol lowering effect has not been found with normolipidemic subjects.…”

“…25 From the previous studies, RS played a useful role in health by some potential mechanisms include: ① changes in intestinal microbiota, ② a reduction in insulin, ③ resistance rise in HDL-c concentrations, and ④ an increase in SCFAs production. [3][4][5][6][26][27][28][29][30][31][32][33][34] RS could produce SCFAs through two pathways: directly (RS fermentation) or indirectly (increasing colonic butyrate-producing microbiota such as Lachnospiraceae and Ruminococcaceae). Butyrate can control macrophage activity and expression of NF-κB which is the main inflammatory and immune response.…”

“…Journal of Advances in Health 2019;1 (4) articles were fewer, which resulted in a high heterogeneity. However, in subgroup analysis, the number of some subgroups included in the study were very few, which the results provided may not be true.…”

Grown to be Blue—Antioxidant Properties and Health Effects of Colored Vegetables. Part I: Root Vegetables

“…Tuber flesh color can be white, yellow, red, or purple depending on the cultivar, with significant differences in bioactive compound content and antioxidant properties [194,195]. Purple yam or water yam (Dioscorea alata purpurea) is usually cultivated in tropical and subtropical regions of the world, and its edible roots are very rich in starch and amylose [196], although a great variation in chemical composition of the edible parts of the species was reported [197]. Resistant starch from purple yam (D. alata) was effective against hyperlipidemia in high-fat diet-fed hamsters through the amelioration of lipid metabolism and the modulation of gut microbiota [196,198].…”

“…Purple yam or water yam (Dioscorea alata purpurea) is usually cultivated in tropical and subtropical regions of the world, and its edible roots are very rich in starch and amylose [196], although a great variation in chemical composition of the edible parts of the species was reported [197]. Resistant starch from purple yam (D. alata) was effective against hyperlipidemia in high-fat diet-fed hamsters through the amelioration of lipid metabolism and the modulation of gut microbiota [196,198]. Moreover, extracts from roots significantly reduced blood glucose levels in Wistar rats with alloxan-induced hyperglycemia [199] or cholesterol (total and low-density lipoprotein (LDL)) and triglycerides in hypercholesterolemic rats [200], ameliorated doxorubicin (DOX)-induced cardiotoxicity [201], showed protective effects against aniline-induced spleen toxicity [202] and in vivo anti-inflammatory activities against λ-carrageenan-induced paw edema in mice [203], and could be used as an adjuvant in bone-marrow-derived dendritic cell (DC)-based vaccines for cancer therapy [204].…”