The beneficial effects of <i>Lactobacillus brevis</i> FZU0713-fermented <i>Laminaria japonica</i> on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet

Zhang, Qing; Xia, Fan; Cao, Ying-Jia; Zheng, Tingting; Cheng, Wenjian; Chen, Lijiao; Lv, Xu-Cong; Ni, Li; Rao, Pingfan; Peng, Liang

doi:10.1039/d1fo00218j

Cited by 29 publications

(25 citation statements)

References 43 publications

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“…L. plantarum FZU3013, isolated from the fermentation of Hongqu rice wine, was obtained from the Institute of Food Science and Technology, Fuzhou University ( 6 , 26 ). This strain was cultured in the MRS medium for 36 h under static conditions, and then sub-cultured three times.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

Zheng

Zeng

et al. 2021

Front. Nutr.

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In this study, we explored the effect of Lactobacillus plantarum FZU3013-fermented Laminaria japonica (LPLJ) supplementation to prevent hyperlipidaemia in rats fed with a high-fat diet (HFD). The results indicate that LPLJ supplementation improved serum and hepatic biochemical indicators (p < 0.05), elevated short-chain fatty acid levels, reduced HFD-induced accumulation of lipid droplets in the liver, modulated the relative abundance of some microbial phylotypes, and reduced hyperlipidaemia in HFD-fed rats by adjusting the aminoacyl-tRNA, phenylalanine, tyrosine, and tryptophan biosynthetic pathways, as well as the phenylalanine, D-glutamine and D-glutamate, and glutathione metabolic pathways. Additionally, hepatic mRNA levels of the genes involved in lipid metabolism and bile acid homeostasis were significantly reduced by LPLJ intervention (p < 0.05). These results suggest that LPLJ has a positive effect on modulating lipid metabolism and has the potential to be a functional food that can help prevent hyperlipidaemia.

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Section: Methodsmentioning

confidence: 99%

“…Laminaria japonica (LJ) has diverse bioactive compounds, such as proteins, polysaccharides, and vitamins (6,7). Polysaccharides are an important active constituent of LJ and have a variety of physiological functions, including hypolipidemic capacity, bile acid (BA)-binding, anti-atherosclerosis, and anti-bacterial activities (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

Zheng

Zeng

et al. 2021

Front. Nutr.

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“…The era has passed in which the microbiome could simply be ignored in the practice of medicine. [184][185][186][187][188][189][190][191][192][193][194][195].…”

Section: Probiotics Prebiotics and Targeted Rebiosis: Clinical And Preclinical Examplesmentioning

confidence: 99%

Microbiome First Medicine in Health and Safety

Dietert¹

2021

Preprint

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Microbiome First Medicine is a suggested 21st century healthcare paradigm that prioritizes the entire human, the human superorganism, beginning with the microbiome. To date, much of medicine has protected and treated patients as if they were a single species. This has resulted in unintended damage to the microbiome and an epidemic of chronic disorders [e.g., noncommunicable diseases and conditions (NCDs)]. Along with NCDs came loss of colonization re-sistance, increased susceptibility to infectious diseases, and increasing multimorbidity and polypharmacy over the life course. To move toward sustainable healthcare, the human micro-biome needs to be front and center. This paper presents microbiome-human physiology from the view of systems biology regulation. It also details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome. Examples are provided for two entryway NCDs, asthma and obesity, regarding their extensive network of comorbid NCDs. Finally, the challenges of ensuring safety for the microbiome are detailed. Under Microbiome First Medicine and considering the importance of keystone bacteria and critical windows of development, changes in even a few microbiota-prioritized medical decisions could make a significant difference in health across the life course.

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“…japonica has rich nutritional value and is a natural health food, and its nutritional value has been extensively studied. For example, polysaccharides extracted from S. japonica can regulate intestinal microflora in high-fat-diet-induced diabetic mice [21], laminarin from S. japonica has good antioxidant capacity [22], and S. japonica fermented by Lactobacillus brevis FZU0713 has a potential function in lipid metabolism [23]. However, during the process of extracting the active ingredients from S. japonica, a large number of byproducts will be produced, which will result in energy waste and pollution if not treated in time.…”

Section: Introductionmentioning

confidence: 99%

Regulatory Effects of Functional Soluble Dietary Fiber from Saccharina japonica Byproduct on the Liver of Obese Mice with Type 2 Diabetes Mellitus

Zhang

Wang

et al. 2022

Marine Drugs

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Though the relationship between dietary fiber and physical health has been investigated widely, the use of dietary fiber from marine plants has been investigated relatively rarely. The Saccharina japonica byproducts after the production of algin contain a large amount of insoluble polysaccharide, which will cause a waste of resources if ignored. Soluble dietary fiber (SDF)prepared from waste byproducts of Saccharina japonica by alkaline hydrolysis method for the first time had a wrinkled microscopic surface and low crystallinity, which not only significantly reduced liver index, serum levels of aspartate aminotransferase (AST) and alanine amiotransferase (ALT), and liver fat accumulation damage to the livers of obese diabetic mice, but also activated the PI3K/AKT signaling pathway to increase liver glycogen synthesis and glycolysis. By LC-MS/MS employing a Nexera UPLC tandem QE high-resolution mass spectrometer, the 6 potential biomarker metabolites were screened, namely glycerophosphocholine (GPC), phosphocholine (PCho), pantothenic acid, glutathione (GSH), oxidized glutathione (GSSG), and betaine; several pathways of these metabolites were associated with lipid metabolism, glycogen metabolism, and amino acid metabolism in the liver were observed. This study further provided a detailed insight into the mechanisms of SDF from Saccharina japonica byproducts in regulating the livers of obese mice with type 2 diabetes and laid a reliable foundation for the further development and utilization of Saccharina japonica.

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The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet

Abstract: This study aimed to investigate the beneficial effects of oral administration of Lactobacillus brevis FZU0713-fermented Laminaria japonica (FLJ) on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed a high-fat...

Cited by 29 publications

References 43 publications

Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

Microbiome First Medicine in Health and Safety

Regulatory Effects of Functional Soluble Dietary Fiber from Saccharina japonica Byproduct on the Liver of Obese Mice with Type 2 Diabetes Mellitus

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