The beneficial effect of OST-6 (OsteoCare), a herbomineral formulation, in experimental osteoporosis

Mitra, S.; Venkataranganna, Marikunte V; Udupa, U. Venkatesh; Gopumadhavan, S; Seshadri, S. J.; Rafiq, Mohamed; Anturlikar, S. D.; Sundaram, R.; Tripathi, Mayur S.

doi:10.1078/0944-7113-00034

Cited by 14 publications

(16 citation statements)

References 20 publications

(19 reference statements)

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“…In addition to these in vitro observations, the positive effects of Osteocare on ALP activity have also been reported during clinical trials of rickets in rats [14]. Taken together, the increase in ALP activity due to WSCO supports the earlier views on the anabolic effects of Osteocare on bone formation [2, 15, 16]. …”

Section: Discussionsupporting

confidence: 73%

“…The most common type of osteoporosis is the bone loss associated with ovarian hormone deficiency at menopause [2]. During osteoporosis, the total skeletal mass decreases due to an imbalance between the resorption of bone by osteoclasts and subsequent formation of bone by osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic effects of Osteocare on osteoporosis and bone loss were reported by many workers [2, 14–16]. However, the cellular and molecular mechanisms of Osteocare and its effects on proliferation, differentiation, and matrix mineralization have yet to be explored.…”

Section: Introductionmentioning

confidence: 99%

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Water Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells

Varma¹,

Kumar²,

Vidyashankar³

et al. 2014

Sci. Pharm.

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Osteocare, a herbal formulation, has been found to be very effective in bone mineralization and support of the microstructure of bone tissue. The water-soluble components of Osteocare (WSCO) induced osteogenic activity in human osteoblast-like SaOS-2 cells. The addition of WSCO (100 μg/ml) to SaOS-2 cells was effective in increasing the cell proliferation by 41.49% and DNA content by 1.9-fold. WSCO increased matrix mineralization in SaOS-2 cells by increased alkaline phosphatase levels and calcium-rich deposits as observed by Alizarin red staining. WSCO markedly increased mRNA expression for osteopontin (OPN), osteocalcin (OCN), type I collagen (Col I) in SaOS-2 cells, and it down-regulated IL-6 mRNA levels in SaOS-2 cells. The present study showed that WSCO plays an important role in osteoblastic bone formation through enhanced activities of ALP, Col I, bone matrix proteins such as OPN and OCN, down-regulation of cytokines like IL-6, as well as promoting mineralization in SaOS-2 cells.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Water Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells

Varma¹,

Kumar²,

Vidyashankar³

et al. 2014

Sci. Pharm.

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“…For instance, Praval bhasma, a natural calcium (Ca) source from India, was found to be effective in the prevention of bone loss induced by Ca deficiency as well as estrogen deficiency, 15 and OST-6, a herbomineral formula containing P. bhasma as one of the main ingredients, also preserved bone loss in Ca-deficient OVX animals. 16,17 Another herb, Puerariae radix, a well-known isoflavone source in China, exerted preventive effects on osteoporosis as well. 18 Although numerous studies have contributed to the great progress in osteoporosis therapy, problems including undesirable side effects and long-term safety issues remain.…”

Section: Introduction O Steoporosis Is a Systemic Skeletal Disease Chmentioning

confidence: 99%

Effect of Korean Oriental Medicine Extract on Bone Mass as Compared with Alendronate in Ovariectomized Rats

Lee

Jhee²,

Yuan³

et al. 2005

Journal of Medicinal Food

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A number of alternative medicines (AMs) have often been used as traditional therapies for various diseases without scientific or clinical evidence supporting their use. The present study examined the pharmaceutical effects of an AM extract with a long history of use as a traditional medicine for various bone diseases. To evaluate it as a potential candidate for use as an anti-osteoporotic drug, we investigated the effects of the AM extract on the progression of bone loss in ovariectomized (OVX) rats fed a calcium (Ca)-deficient diet for 4 or 12 weeks. We also compared the AM extract with alendronate, an anti-resorptive drug. The AM extract did not influence bone turnover as indicated by biochemical markers [i.e., deoxypyridinoline (DPD)]. In contrast, alendronate treatment seemed to reduce bone turnover via inhibition of bone resorption as evidenced by reduced urinary DPD concentrations accompanied by a tendency for decreased serum tartrate-resistant acid phosphatase. Administration of alendronate or AM extracts did not significantly affect bone density, although both tended to increase bone mineral density (BMD) and bone strength of the femur. Although both treatments did not affect vertebral BMD and bone strength, histological analysis of vertebrae showed well-developed trabecular networking in OVX rats treated with alendronate or AM extract, in contrast to the thin and disconnected trabecule in OVX rats. In conclusion, the AM extract produced a very weak effect on the prevention of bone loss induced by OVX and Ca deficiency in rats, but was similar to the results observed with alendronate. Further verification is necessary to justify the use of the AM extract as a treatment for osteoporosis.

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“…Conventional treatment results in varied adverse effects such as increased incidence of endometrial and breast cancer with hormonal replacement therapy, pseudo-arthritis with fluo-ride treatment, extra skeletal effects in cases treated with growth factors such as insulin like growth factor I and II and transforming growth factor [10,11]. Considering the broad range of effects of osteoporosis on the medical and health system, currently there is an increasing demand for alternative medications that can prevent and cure this silent ailment [12]. In this paper, we have reviewed the literature related to a selected medicinal herb, Quercus infectoria which may act specifically on osteoblastic proliferation and differentiation.…”

Section: Introductionmentioning

confidence: 99%

The Potential Role of Quercus Infectoria Gall Extract on Osteoblast Function and Bone Metabolism

Hapidin¹,

Abdullah²,

Soelaiman³

2012

OJEMD

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The galls of the Quercus infectoria (QI) tree are traditionally believed to have great medicinal value. Pharmacologically the galls are claimed to have various biological activities such as astringent effect, antidiabetic, antitremorine, local anaesthetic, antipyretic, anti-inflammatory, antibacterial, antiviral and many more. These pharmacological activities of gall extracts were reported to be due to its excellent antioxidant activity with phytochemicals constituents of phenolic and flavanoid compounds. The phenolic compounds or polyphenols can act on bone metabolism by modulating osteoblast proliferation, differentiation and mineralization, as well as osteoclastogenesis. In addition, elemental and physico-chemical analysis indicated the presence of important minerals in QI, such as calcium, magnesium, phosphorus, oxygen, potassium, aluminium, carbon, zinc, iron, manganese, nickel and silica. The current review will be focusing on the potential bone health benefits of the well-known traditional herbal medicine, QI or locally known as the "manjakani".

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The beneficial effect of OST-6 (OsteoCare), a herbomineral formulation, in experimental osteoporosis

Cited by 14 publications

References 20 publications

Water Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells

Water Soluble Components of ‘Osteocare’ Promote Cell Proliferation, Differentiation, and Matrix Mineralization in Human Osteoblast-Like SaOS-2 Cells

Effect of Korean Oriental Medicine Extract on Bone Mass as Compared with Alendronate in Ovariectomized Rats

The Potential Role of Quercus Infectoria Gall Extract on Osteoblast Function and Bone Metabolism

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