The beneficial effect of mild therapeutic hypothermia depends on the time of complete circulatory standstill in patients with cardiac arrest

The effect of mild therapeutic hypothermia on good neurological recovery after out-of-hospital cardiac arrest according to location of return of spontaneous circulation: A nationwide observational study

“…Animal studies have shown that ischemic brain damage after cardiac arrest increased when time interval from arrest to ROSC was beyond 8 min. 24,25 Additionally, Testori et al 26 reported that when the duration of complete circulatory standstill increased, the positive effects of MTH in OHCA patients increased. These findings implicate early ROSC as the lacking factor for patients who display diminished effect of MTH.…”

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33°C and 36°C

“…3,[6][7][8] Based on the classification of cardiac arrest into three stages by Weisfeld and Becker it has been suggested that patients in the metabolic phase of arrest, which include those with more than 10 min of no-flow time (time from cardiac arrest to start of cardiopulmonary resuscitation (CPR) would be particularly responsive to TTM. 9,10 This hypothesis is to some extent supported by animal studies showing that ischemia persisting beyond 8 min is progressively associated with worse neurological outcomes.…”

Therapeutic Whole-body Hypothermia Protects Remote Lung, Liver, and Kidney Injuries after Blast Limb Trauma in Rats

“…It has been recognized that the therapy window and the duration of WH are very important for achieving promising protective outcome. In general, the early application of therapeutic hypothermia can be more effective than later application 13,14 . Mild hypothermia is preferable because it can provide considerable protective effects and has minimal adverse effects 15,16 .…”