The Behaviour of Bis(Diphenylphosphino)Alkanes towards Different Active Centres

Abstract

The reactions of bis(diphenylphosphino)alkanes with benzophenone, bis(piperidinocarbonyl)diazene, isatin, and quinoxaline1,4-di- N-oxide have been studied and the products characterised by elemental analysis and spectroscopic measurements.

Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors

“…Accordingly, and in continuation of our ongoing research (Boulos et al, 2013a;El-Sayed et al, 2016;Ewies et al, 2014;Ewies et al, 2015;Ewies et al, 2016a;Ewies et al, 2016b;Ewies et al, 2019;Ibrahim et al, 2015, El-Husseiny et al, 2020El-Sayed et al, 2020) toward obtaining new compounds as promising biological activities and based on F I G U R E 2 Design of target compounds 5a-j, 6a,b, 7a-e, and 8a-f the previously reported findings regarding the biological activity of benzofuran and indole nucleus, we focused our attention on exploring the possibility of replacement of the 3,4,5-trimethoxybenzoyl moiety at position 2 of compound IV with a fluoro or trifluoromethyl substituted phenyl diazinyl moiety as in compounds 5a-j, 6a,b, and 8a-f. Both fluorine substituent or trifluoromethyl group are known to induce high effect on the binding affinity and increase stability of cell membrane as well as its permeability against metabolic oxidation (Usachev et al, 2008;Usachev et al, 2012).…”

Preparation of novel azidopyrazole derivatives with anticipated cytotoxic and antimicrobial activities

“…Moreover, azides are important building blocks due to their potential application in organic and bioorganic chemical reactions . In the light of this survey and our interest in synthesis of heterocyclic chemistry, we have now studied the reactivity of azidopyrazole carbaldehyde 1 towards certain active methylenes ( 2a‐e , 3 ), primary amines ( 4a‐g ), and hydrazines ( 4h‐k ) aiming at preparing new heterocycles of anticipated anticancer and antimicrobial activities (Figure ).…”

Synthesis, Characterization and antimicrobial activity of novel pyrrolidine-3-carbonitrile derivatives,

“…[16] Based on the literature survey and as a part of our growing interest in preparing new organophosphorus compounds. [17][18][19][20] In this article we studied the chemical behavior of 4-cyano-pyrrolidin-3-ones (1) towards organophosphorus reagents and evaluation the antimicrobial activity of the products (Fig. 1).…”