The behavioral effects of lesions of the septum: A review

Chozick, Bruce S.

doi:10.3109/00207458508985617

Cited by 15 publications

(6 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In mammals, mainly the lateral septum sends strong inhibitory projections to the hypothalamus, whereas projections from the medial septum seem weaker (Jakab and Leranth, 1995). Thus, the mammalian lateral septum may regulate neuroendocrine functions associated with water and salt intake, food intake, thermophysiological processes during hibernation, aggressiveness, and sexually related behaviors (for review, see Fried, 1972;Chozick, 1985;Jakab and Leranth, 1995), and the same may be true for amphibians.…”

Section: Comparative and Functional Aspectsmentioning

confidence: 99%

“…In mammals, the septal complex is part of the limbic system and is involved in various functions (for reviews, see Fried, 1972;Gray and McNaughton, 1983;Chozick, 1985), e.g., aggressive-defensive behavior, motivation, food and water intake, learning, sexual behavior (Tsukahara and Yamanouchi, 2001), blood pressure regulation (Covian, 1967;Kubo et al, 2002), thermoregulation (Crawshaw et al, 1985;Cooper et al, 1987), and vocalization (Bihari et al, 2003). Only some of these functions have been assigned to different septal nuclei or even to specific connections.…”

Section: Indexing Terms: Septal Complex; Neurobiotin Tracing; Gray Trmentioning

confidence: 99%

See 1 more Smart Citation

Hodological characterization of the septum in anuran amphibians: II. Efferent connections

Endepols¹,

Roden²,

Walkowiak³

2005

J of Comparative Neurology

View full text Add to dashboard Cite

The efferent connections of the septum of the gray treefrog Hyla versicolor were studied by combining anterograde and retrograde tracing with biotin ethylendiamine (Neurobiotin). The lateral septal complex projects mainly to the medial pallium, limbic regions (e.g., amygdala and nucleus accumbens), and hypothalamic areas but also to sensory nuclei in the diencephalon and midbrain. The central septal complex strongly innervates the medial pallium, limbic, and hypothalamic areas but also specific sensory (including olfactory) regions. The medial septal complex sends major projections to all olfactory nuclei and a weaker projection to the hypothalamus. Our results indicate that all septal nuclei may modify the animal's internal state via efferents to limbic and hypothalamic areas. Via projections to the medial pallium, lateral and central septal complexes may be involved in learning processes as well. Because of their connections to specific sensory areas, all septal areas are in a position to influence sensory processing. Furthermore, our data suggest that both the postolfactory eminence and the bed nucleus of the pallial commissure are not part of the septal complex, rather, the postolfactory eminence seems to be comparable to the mammalian primary olfactory cortex, whereas the bed nucleus may be analogous to the mammalian subfornical organ.

show abstract

Section: Comparative and Functional Aspectsmentioning

confidence: 99%

Section: Indexing Terms: Septal Complex; Neurobiotin Tracing; Gray Trmentioning

confidence: 99%

Hodological characterization of the septum in anuran amphibians: II. Efferent connections

Endepols¹,

Roden²,

Walkowiak³

2005

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…Lesion studies have revealed a number of behavioral processes for which the integrity of the hippocampus is critical, most prominently, tasks that require processing of spatial information (O'Keefe and Nadel, 1978: Olton et al, 1979: Chozick, 1983: Morris, 1983Schmajuk, 1984), while hippocampal lesion effects related to so-called nonspatial behavior have been reported less frequently but fairly regularly (Gray, 1982;Schmajuk, 1984;Rawlins, 1985;Tonkiss et al, 1988: Sutherland et a]., 1989Jagielo et al, 1990). The data from these correlational studies are congruent with lesion data in revealing an important involvement of hippocampal circuitry in swimming navigation, particularly in its purest form: reversal learning and crossing over the former platform location.…”

Section: Functional Implicationsmentioning

confidence: 99%

Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse

et al. 1991

View full text Add to dashboard Cite

The extent of the infrapyramidal mossy fiber projection in CA3 (IIP-MF) at the midseptotemporal level correlates negatively with two-way avoidance learning and positively with performance in the radial maze, both tasks known to be sensitive to hippocampal lesions. If hippocampal structural variations are causing behavioral variations, one must predict positive correlations between the extent of the IIP-MF and performance in swimming navigation. Thus, the authors studied learning and reversal learning of swimming navigation in mice in which the size of the IIP-MF had been randomized by means of systematic crosses and in 2 mouse strains known for differential infrapyramidal projections (C57BL/6 and DBA/2). In 19 random-bred mice (9 male, 10 female), the extent of the IIP-MF showed negative correlations with swimming time after platform reversal (day 4: r = -0.50, P < .03; day 5 r = -0.73, P < .001), but none during acquisition of the task. In addition, statistical analysis suggested an influence of asymmetrically distributed mossy fiber projections during reversal learning. The strain comparison between 18 DBA/2 and 16 C57BL/6 male mice confirmed these results: no strain difference during days 1-3, and a significantly faster swimming time in the strain C57BL/6 (with large IIP-MF) at day 5 (second day of reversal), associated with significantly more crossings of the former platform location during the early phases of reversal learning. This latter measure was also negatively correlated with asymmetry of the IIP-MF in both strains. Finally, variations of the IIP-MF were correlated partially with adjustment of swimming speed that appeared to depend on size and asymmetry of CA4 as well. Thus, natural variations in the size of the IIP-MF distribution, and, perhaps, of CA4, appear to linearly influence processes directly involved in complex spatial learning.

show abstract

“…Plasma Cpd B responses to stimulation o f the intermediate area o f the lateral septal nucleus produced varying and incon sistent responses. Collectively, these data support the hypothesis that subdivisions within the septal nuclei are differen tially involved in adrenocortical function.The septal region has attracted considerable attention because o f its apparent involvement in a variety of associa tive, emotional and motivational processes [3,4, 21]. Addi tionally, a sizeable literature exists regarding a septal influence on pituitary-adrenal dynamics.…”

mentioning

confidence: 99%

Differential Plasma Corticosterone Responses to Electrical Stimulation of the Medial and Lateral Septal Nuclei

Dunn¹

1987

Neuroendocrinology

View full text Add to dashboard Cite

To pursue the possibility that subdivisions within the medial and lateral septal nuclei are differentially involved in adrenocortical function, plasma samples obtained prior to and following electrical stimulation of the septal nuclei of urethane (1.30 g/kg)-anesthetized female rats were assessed for corticosterone concentration. Hippocampal EEG, ECG, heart rate (HR), mean arterial pressure (MAP) and respiration were routinely monitored, and timed blood samples (0.15 ml) were obtained from a catheterized tail artery. Blood samples were taken 0.5 min prior to and at 5, 10, 15 and 30 min after initiation of stimulation. Whereas no change in Cpd B levels were observed following sham stimulation or stimulation of the corpus callosum, fornix or anterior commissure, stimulation of the septal nuclei produced differential responses. Decreased plasma Cpd B responses followed stimulation of the medial septal nucleus (MS); increases in plasma Cpd B followed stimulation of the dorsal (LSD) and ventral (LSV) division of the lateral septal nucleus. The overall increase in plasma Cpd B levels following LSD and LSV stimulation was 16 and 32%, respectively. The overall decrease in corticosterone concentration subsequent to MS stimulation was 18%. The largest increases in Cpd B levels occurred at 5 min (36%) and 10 min (24%) for LSV and LSD groups, respectively; the largest decrease was noted at 15 min (25%). Plasma Cpd B responses to stimulation of the intermediate area of the lateral septal nucleus produced varying and inconsistent responses. Collectively, these data support the hypothesis that subdivisions within the septal nuclei are differentially involved in adrenocortical function.

show abstract

The behavioral effects of lesions of the septum: A review

Abstract: Many investigations have been conducted in an effort to deduce the nature of septal function. This paper is an overview of the work done by several researchers in their attempt to find the possible connections between overt behaviors and septal structures in the rat.

Cited by 15 publications

References 104 publications

Hodological characterization of the septum in anuran amphibians: II. Efferent connections

Hodological characterization of the septum in anuran amphibians: II. Efferent connections

Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse

Differential Plasma Corticosterone Responses to Electrical Stimulation of the Medial and Lateral Septal Nuclei

Contact Info

Product

Resources

About