The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders – Current Advances in Human Studies: A Systematic Review

Assis, Gilmara Gomes de; Hoffman, Jay R.

doi:10.3233/bpl-210132

Cited by 9 publications

(7 citation statements)

References 73 publications

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“…Together, the literature on the role of the BDNF polymorphism is controversial and leaves many unresolved issues. It is, overall, consistent with the notion that the Val66Met polymorphism is relevant, but not determinant, as a risk factor for neuropsychiatric disorders [39].…”

Section: Plos Onesupporting

confidence: 88%

Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity

Hertenstein,

Kuhn,

Landmann

et al. 2023

PLoS ONE

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The protein brain-derived neurotrophic factor (BDNF) promotes neural plasticity of the central nervous system and plays an important role for learning and memory. A single nucleotide polymorphism (rs6265) at position 66 in the pro-region of the human BDNF gene, resulting in a substitution of the amino acid valine (val) with methionine (met), leads to attenuated BDNF secretion and has been associated with reduced neurocognitive function. Inhomogeneous results have been found regarding the effect of the BDNF genotype on behavior. We determined the BDNF genotype and performance on the Compound Remote Associate (CRA) task as a common measure of creativity in 76 healthy university students. In our main analyses, we did not find significant differences between met-carriers (n = 30) and non-met carriers (n = 46). In a secondary analysis, we found that met-carriers had a slower solution time (medium effect size) for items of medium difficulty. Our results suggest that met-carriers and non-met-carriers do not generally differ regarding their creativity, but non-met-carriers may have a certain advantage when it comes to moderately difficult problems. The wider literature suggests that both genetic variants come with advantages and disadvantages. Future research needs to sharpen our understanding of the disadvantages and, potentially, advantages met allele carriers may have.

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Section: Plos Onesupporting

confidence: 88%

Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity

Hertenstein,

Kuhn,

Landmann

et al. 2023

PLoS ONE

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“…Results from a human study indicated that metabolic stress downregulates the expression of BDNF but not concentrations of plasma BDNF [ 93 ]. An alteration in the pro-BDNF/BDNF ratio deriving from the rs6265 polymorphism might be important to consider [ 94 ]. A complete overview of this complex system is out of scope for this paper.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the Moderating Effects of Physical Activity and Early Life Stress on the Relation between Brain-Derived Neurotrophic Factor (BDNF) rs6265 Variants and Depressive Symptoms among Adolescents

Soler

Kanders

Olofsdotter

et al. 2022

Genes

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Depression affects one in five persons at 18 years of age. Allele A of the brain-derived neurotrophic factor (BDNF) rs6265 is considered to be a risk factor for depression. Previous studies of the interaction between BDNF rs6265, early adversity, and/or physical activity have shown mixed results. In this study, we explored the relation between BDNF rs6265 polymorphism and childhood stress, as well as the moderating effect of physical activity in relation to depressive symptoms using binary logistic regressions and process models 1, 2 and 3 applied to data obtained at three times (waves 1, 2 and 3) from the Survey of Adolescent Life in Västmanland cohort study (SALVe). Results revealed that both childhood stress and physical activity had a moderation effect; physical activity in wave 1 with an R2 change = 0.006, p = 0.013, and the Johnson–Neyman regions of significance (RoS) below 1.259, p = 0.05 for 11.97%; childhood stress in wave 2 with the R2 change = 0.008, p = 0 002, and RoS below 1.561 with 26.71% and >4.515 with 18.20%; and a three-way interaction in wave 1 in genotype AA carriers. These results suggest that allele A is susceptible to physical activity (positive environment) and childhood stress (negative environment).

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“…In our previous research, we showed that the BDNF Val66Met polymorphism might negatively influence BDNF secretion by affecting different stages of its synthesis. It affects cleavage and trafficking processing of proBDNF throughout the secretory pathways, resulting in a less efficient distribution of BDNF in the dendrites and axons or its activity-dependent release from synaptic terminals [31,32]. the influence of BDNF on stroke outcomes was first reported in patients of haemorrhagic stroke (31 Met carriers and 65 Val homozygous) investigated by Vilkki et al [33] when they noticed that Met carriers showed inferior learning and memory capability one year after stroke (table 1).…”

Section: Influence Of Bdnf Val66met (Rs6265) Polymorphismmentioning

confidence: 99%

“…It came to our attention that, whereas the common Val66Met polymorphism in BDNF gene is reported to affect several processes of the protein synthesis [32], this is not directly reflected in the circulating serum levels [29,31]. this leads to the interpretation that a slight misfunctioning in such an essential protein for the proper neuronal function is tolerable, although it does represent a vulnerability to the development of neuropathological conditions.…”

Section: Highlights and Final Considerationsmentioning

confidence: 99%

Brain-derived neurotrophic factor and stroke: perspectives on exercise as a health care strategy

De Assis,

Murawska-Ciałowicz

2024

Hum Mov.

Self Cite

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PurposeStroke is the second most common cause of mortality worldwide and the third most common cause of motor disability. From another perspective, brain-derived neurotrophic factor (BDNF) is a metabolite that plays several neuroprotective roles. While cardiometabolic diseases are the leading cause of stroke, BDNF represents a target factor in the prevention and/or recovery from stroke. Aim: In this narrative review, I have summarised the clinical evidence of BDNF participation in the recovery from a stroke and discuss the potential use of exercise as a rehabilitation tool.MethodsMultiple combinations of the terms ‘brain infarction’, ‘cerebral infarction’, ‘hemorrhagic stroke’, ‘ischemic stroke’, ‘embolic stroke’ or ‘thrombotic stroke’ AND ‘BDNF’ or ‘pro-BDNF’ were used in PubMed databases. Studies not available in the English language or addressing animal experiments were excluded.Results and prospectsSeventeen clinical studies published up to June 30th of 2023 were included in this review. Changes in the patients circulating BDNF levels represent their capability of recovery from the stroke outcomes. A subtle, but consistent, negative influence of the presence of the 66Met-allele in BDNF on motor and cognitive competencies is seen in patients recovering from a stroke throughout the studies – an effect that is not reportedly detectable in other neuropathological conditions. Exercise exerts a positive modulation on BDNF levels that accompanies improvements in stroke recovery and might exert a preventive role against the severity of stroke outcomes.

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The BDNF Val66Met Polymorphism is a Relevant, But not Determinant, Risk Factor in the Etiology of Neuropsychiatric Disorders – Current Advances in Human Studies: A Systematic Review

Cited by 9 publications

References 73 publications

Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity

Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity

Exploration of the Moderating Effects of Physical Activity and Early Life Stress on the Relation between Brain-Derived Neurotrophic Factor (BDNF) rs6265 Variants and Depressive Symptoms among Adolescents

Brain-derived neurotrophic factor and stroke: perspectives on exercise as a health care strategy

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